Electrocardiographic Evidence of Cardiac Disease by Sex and HIV Serostatus in Mbarara, Uganda

Kentoffio, Katherine; Albano, Alfred; Koplan, Bruce A.; Feng, Maggie; Muthalaly, Rahul G.; Campbell, Jeffrey I.; Sentongo, Ruth; Tracy, Russell P.; Peck, Robert; Okello, Samson; Tsai, Alexander C.; Siedner, Mark J.

doi:10.1016/j.gheart.2019.08.007

Cited by 7 publications

(17 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several studies have shown an increased prevalence of secondary markers of CVD in women, such as ischemic findings on ECG in Uganda, and angina symptoms as reported on the Rose Angina Questionnaire in South Africa. 85,96 Numerous studies have looked at carotid intimal-medial thickness (cIMT) as a surrogate for the prevalence of CVD, with mixed results. Ssinabuulya et al found no difference in mean cIMT in WLWH as compared to MLWH in Uganda, whereas Schoffelen et al found a slightly lower mean cIMT among WLWH in South Africa, 97,98 and Nonterah et al demonstrated lower cIMT values among PLWH as compared to the HIV-negative population, with no significant difference by sex.…”

Section: Sexmentioning

confidence: 99%

Prevention of cardiovascular disease among people living with HIV in sub-Saharan Africa

Okello

Almasi‐Hashiani

Bloomfield

et al. 2020

Progress in Cardiovascular Diseases

Self Cite

View full text Add to dashboard Cite

As longevity has increased for people living with HIV (PLWH) in the United States and Europe, there has been a concomitant increase in the prevalence of cardiovascular disease (CVD) risk factors and morbidity in this population. Whereas the availability of HIV antiretroviral therapy has resulted in dramatic increases in life expectancy in sub-Saharan Africa (SSA), where over two thirds of PLWH reside, if and how these trends impact the epidemiology of CVD is less clear. In this review, we describe the current state of the science on how both HIV and its treatment impact CVD risk factors and outcomes among PLWH in sub-Saharan Africa, including regional factors (unique to SSA) likely to differentiate these relationships from the global North. We then outline how current regional guidelines address CVD prevention among PLWH and which clinical and structural interventions are best poised to confront the co-epidemics of HIV and CVD in the *

show abstract

Section: Sexmentioning

confidence: 99%

Prevention of cardiovascular disease among people living with HIV in sub-Saharan Africa

Okello

Almasi‐Hashiani

Bloomfield

et al. 2020

Progress in Cardiovascular Diseases

Self Cite

View full text Add to dashboard Cite

show abstract

“…16 There is greater variability in the QT interval and repolarization abnormalities among male PWH in the setting of measurable HIV viremia and greater burden of prolonged QT interval and ventricular ectopy in PWH compared with uninfected comparators, but most of these observations are from high-income country settings. 12,[16][17][18][19] Identifying ECG abnormalities is important for both immediate clinical management and for predicting and preventing future CVD events. The burden of ECG abnormalities and their relationships to antiretroviral therapy (ART), sex, race, or ethnicity in contemporary global cohorts of middle-aged ART-treated PWH has not been reported.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and Correlates of Electrocardiographic Abnormalities in Adults With HIV: Insights From the Randomized Trial to Prevent Vascular Events in HIV (REPRIEVE)

Bloomfield

Weir

Ribaudo

et al. 2022

JAIDS Journal of Acquired Immune Deficiency Syndromes

View full text Add to dashboard Cite

show abstract

“…Two studies conducted in Nigeria have found higher rates of ECG abnormalities among people living with HIV (on treatment and treatment-naïve) as compared to the general population [ 36 37 ]. A study conducted in Uganda, however, found no statistical difference in the prevalence of ECGs with signs of ischemia or other abnormalities among people living with HIV on treatment as compared to the general population [ 38 ]. Outside of sub-Saharan Africa, a large study from North America on 4,518 participants living with HIV found a two to three fold increase of ECG abnormalities among people living with HIV as compared to estimates on the general population derived from other reported studies using the same ECG classification methods [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

ECG Abnormalities and Arterial Stiffness by HIV Status among High-Risk Populations in Rakai, Uganda: A Pilot Study

et al. 2021

View full text Add to dashboard Cite

Background: People living with HIV are at increased risk for cardiovascular disease (CVD). In sub-Saharan Africa, population-based data on major CVD events such as stroke and myocardial infarction are difficult to collect. The use of proxy measures could be a feasible way to better study CVD in such settings. This study aimed to determine the acceptance of incorporating ECG and arterial function measurements into a population-based cohort study and to assess the prevalence of ECG abnormalities and arterial stiffness. Methods: A pilot study was conducted within the Rakai Community Cohort Study in Uganda on two high-risk CVD populations; one determined by age (35–49) and Framingham CVD risk scores and the other by age alone (50+). Data on ECG, arterial function, blood pressure, and HIV status were collected. The acceptability of incorporating ECG and arterial function measurements was established as an acceptance rate difference of no more than 5% to blood pressure measurements. Results: A total of 118 participants were enrolled, 57 participants living with HIV and 61 HIV-negative participants. Both ECG measurements and arterial function were well accepted (2% difference). Left ventricular hypertrophy (LVH) and arterial stiffness (>10 m/s) were common in both participants living with HIV and HIV-negative participants across the two high-risk populations. Prevalence rates ranged from 30% to 53% for LVH and 25% to 58% for arterial stiffness. Arterial stiffness at the 11 m/s cutoff (p = 0.03) was found to be more common among participants living with HIV in the 35–49 population. Conclusions: The incorporation of ECG and arterial function measurements into routine activities of a population-based cohort was acceptable and incorporating these proxy measures into cohort studies should be explored further. LVH and arterial stiffness were both common irrespective of HIV status with arterial stiffness potentially more common among people living with HIV.

show abstract

Electrocardiographic Evidence of Cardiac Disease by Sex and HIV Serostatus in Mbarara, Uganda

Cited by 7 publications

References 10 publications

Prevention of cardiovascular disease among people living with HIV in sub-Saharan Africa

Prevention of cardiovascular disease among people living with HIV in sub-Saharan Africa

Prevalence and Correlates of Electrocardiographic Abnormalities in Adults With HIV: Insights From the Randomized Trial to Prevent Vascular Events in HIV (REPRIEVE)

ECG Abnormalities and Arterial Stiffness by HIV Status among High-Risk Populations in Rakai, Uganda: A Pilot Study

Contact Info

Product

Resources

About