Electrocardiographic Clues to Identify Nonresponders to Cardiac Resynchronization Therapy

Abstract

Despite the technical wizardry behind CRT and patient system analyzers, the surface ECG should continue to be an invaluable tool for evaluating patients who have undergone CRT.

Evaluating the effects of cardiac resynchronization therapy on pathophysiological pathways of heart failure using surrogate biomarkers

“…Cardiac resynchronization therapy (CRT) is a valuable interventional therapeutic option in patients with systolic HF and left ventricular (LV) conduction disturbances, as it decreases the chances of both morbidity as well as mortality [2,3]. Yet, up to 30-40% of the patients do not benefit from CRT implantation for several reasons [4,5]. Although several studies using circulating biomarkers have been carried out to identify patient responsiveness to CRT [6][7][8][9][10], none could assess all the predefined pathophysiological pathways as a whole in the same patient population.…”