Electrocardiographic Characterization of Rhesus Monkey Model of Ischemic Myocardial Infarction Induced by Left Anterior Descending Artery Ligation

Abstract

Myocardial infarction is a leading cause for morbidity and mortality in the modern society. Rhesus monkeys are excellent animal models for experimental and translational studies of cardiovascular diseases in humans. However, some detailed characterizations of cardiovascular disease, such as myocardial infarction, in Rhesus monkeys have not been available. The present study was undertaken to examine the progressive electrocardiographic changes in Rhesus monkeys after left anterior descending (LAD) artery ligation. Male Rhesus monkeys, aged 2-3 years and weighed 4.5-6.0 kg, were subjected to LAD ligation along with sham-operated controls. At 1 week, 1 month, and 6 months after the LAD ligation, ECG recording was performed to detect the progressive changes in ECG. In addition, cardiac magnetic resonance imaging (MRI) and echocardiography were applied to detect the myocardial infarction induced by LAD ligation, and histopathological examination was performed at the end of the experiment to measure the morphological changes. The results showed that QRS and ST-T changed significantly within 1 month after LAD ligation, but recovered to normal at the end of the experiment. The most significant change was a progressive QTc prolongation, which occurred corresponding to the development of myocardial infarction. Both cardiac MRI and echocardiography detected the myocardial infarction that was confirmed by the histopathological examination. This detailed characterization of ECG changes along with the development of myocardial infarction induced by LAD ligation thus demonstrated that the Rhesus monkey model of ischemic myocardial infarction would be an excellent surrogate for human myocardial infarction. This model would also provide an excellent tool for drug discovery and development for cardiac disease.

Evaluation of the Differences of Myocardial Fibers between Acute and Chronic Myocardial Infarction: Application of Diffusion Tensor Magnetic Resonance Imaging in a Rhesus Monkey Model

“…The voxel-based tensors are the important mechanical microstructures in the myocardial fibers because the wall torsion depends on the movements of the multi-orientation tensors (1624). In the MI-1 hour, the early stage of myocardial ischemia resulted in moderate myocardial edema, but the capillary wall retained its structural integrity, and the myocytes did not undergo extensive apoptosis.…”

“…The objective of this study was to quantify the characteristics of the myocardial fibers during acute and chronic MI, and subsequently identify the differences in myocardial fibers between acute and chronic MI in rhesus monkeys using the DT-MRI method, in order to understand the corresponding changes in patients with acute MI (16). …”

Decreases in Electrocardiographic R-Wave Amplitude and QT Interval Predict Myocardial Ischemic Infarction in Rhesus Monkeys with Left Anterior Descending Artery Ligation

“…QT-prolongation is a parameter that can be used as a marker for myocardial infarction [9]. Both acute and chronic myocardial infarctions are associated with QT-prolongation [10], [11].…”

Influência de diferentes protocolos de contenção nosvalores do eletrocardiograma de macacos-da-noite (Aotus azarae infulatus)

“…Não existe consenso em relação ao posicionamento de primatas para a realização do ECG, sendo adotada posição supina do animal, de forma semelhante ao descrito por Yang et al (2011). A duração da onda P verificada corrobora com o descrito por Baer (1994) em Aotus mas foi maior do que o citado por Rajendra et al (2010) nesta mesma espécie.…”