Stroke is a cerebrovascular event where in neurological deficit develops over minutes or hours, in a stepwise fashion, persists for twenty-four hours or more and is because of a vascular disturbance which include arterial occlusion with consequent ischemic focal infarction of the brain. Various studies confirmed myocardial damage in stroke. So this study was done to assess the cardiac damage with the usage of CK-MB, Trop -T in patients with acute stroke .Cardiac enzymes like creatine kinase (CK-MB)and Troponin-T studied in these patients showed that CK-MB which was specific for myocardial infarction loses its specificity in patients with stroke. CK-MB elevation in these patients does not indicate cardiac damage. Troponin -T was negative in most of the patients.