Electrocardiographic alterations associated with heart transplantation. Triggers, mechanisms and meaning

Figueroa-Bohórquez, David Mauricio; Benavides, Xiomara; Garzón, Luz; Espinel, Daniel; Suárez, Luis D.; Uribe, M. Jaramillo; Gómez-Aristizabal, Linda; Márquez, Eyner Lozano

doi:10.15446/revfacmed.v65n3.57498

Cited by 1 publication

(1 citation statement)

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“…During solid organ transplantation, the immune system generates a response that is attributed to rejection, which is mediated by antibodies, T cells or vascular disturbances; in this response, antibody rejection is the worst prognosis. 52,53 Immunosuppressive drugs used in transplants produce a large number of side effects, 54 including nephrotoxicity, malignancy, hypertension, diabetes and infections. Cytomegalovirus infection is one of the most common.…”

Section: Cd4+cd25+foxp3 Cd4+cd25+mentioning

confidence: 99%

Inducción de tolerancia por vía oral en trasplante de órganos y tejidos. Revisión de la Literatura

et al. 2020

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Introduction:Oral tolerance is defined as the suppression of the immune response to antigens that have been previously administered orally. The purpose of inducing oral tolerance is to avoid using immunosuppressive drugs since, considering that they are not antigen-specific, they make the host more susceptible to acquire infections and develop neoplasms. Objective: To carry out a literature review on the most relevant theoretical references regarding oral tolerance induction in organ and tissue transplantation to prove that oral tolerance is a viable alternative therapy in transplant patients. Materials and methods: A literature review was conducted in the PubMed, MEDLINE, LILACS and Embase databases using the following search strategy: publication time: no limits; publication language: English and Spanish; type of studies: case-control studies, literature and systematic reviews; search terms: "T-Lymphocytes, Regulatory", "Autoimmunity", Immunosuppression", "Immune system" and "Immune Tolerance", and their equivalents in Spanish. Results: After the initial search was completed, 719 records were retrieved; however, only 99 addressed oral tolerance induction. Once duplicate records and articles without full-text access were removed, 75 studies were included for analysis. Conclusions: Oral administration of antigens is an effective way to induce immune tolerance in transplant patients (murine models) as it eliminates the adverse effects associated with immunosuppressive therapy, which currently is the standard therapy to treat these patients worldwide.Introducción. La tolerancia oral es la supresión de la respuesta inmune a antígenos administrados con anterioridad por vía oral; su inducción tiene el propósito de evitar el uso de fármacos inmunosupresores, los cuales, dado que son poco específicos a antígenos, vuelven al huésped más susceptible de contraer infecciones y desarrollar neoplasias. Objetivos. Realizar una revisión de la literatura sobre los referentes teóricos más relevantes de la inducción de a tolerancia oral en lo que respecta al trasplante de órganos y tejidos para demostrar que el uso de esta alternativa terapéutica es viable en pacientes trasplantados. Materiales y métodos. Se realizó una revisión de la literatura en PubMed, MEDLINE, LILACS y Embase mediante la siguiente estrategia de búsqueda: periodo de publicación: sin límites; idiomas: Inglés y Español; tipo de artículos: estudios caso-control, revisiones sistemáticas y de la literatura; términos de búsqueda: "T-Lymphocytes, Regulatory", "Autoimmunity", Immunosuppression", "Immune system" and "Immune Tolerance", y sus equivalentes en español. Resultados. La búsqueda inicial arrojó 719 registros, sin embargo solo 99 abordaban la inducción de la tolerancia oral. Una vez los registros duplicados y los artículos sin acceso a texto completo fueron removidos, se incluyeron 72 estudios en la revisión. Conclusiones. La administración oral de antígenos es una opción efectiva para inducir tolerancia inmunológica en pacientes trasplantados (modelos murinos...

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Section: Cd4+cd25+foxp3 Cd4+cd25+mentioning

confidence: 99%