Electrocardiographic Accompaniments of Temporal Lobe Epileptic Seizures

Blumhardt, L D; Smith, Pem; Owen, Lynne

doi:10.1016/s0140-6736(86)91328-0

Cited by 251 publications

(177 citation statements)

References 25 publications

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“…6 In this child, the duration of the bradycardia was only for a few seconds and thus not associated with hemodynamic impairment. However, since the child was operated relatively soon after the diagnosis of pharmacoresistant epilepsy, we cannot exclude that the bradycardia may have ultimately become more significant with time if the seizure disorder had remained uncontrolled.…”

Section: Discussionmentioning

confidence: 67%

Ictal bradycardia in a young child with focal cortical dysplasia in the right insular cortex

Seeck¹,

Zaim

Chaves-Vischer

et al. 2003

European Journal of Paediatric Neurology

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Summary We report on a three and a half year old child with episodic sinus bradycardia during habitual seizures and prolonged interictal discharges due to focal cortical dysplasia in the anterior 2/3 of the insula and the inferior frontal cortex. Seizureinduced bradycardia is rarely reported in children. Bradycardia is suspected to be related to sudden death, a rare complication of a chronic seizure disorder. Several well-documented cases in adult patients reveal a high incidence of temporal epilepsy, but MRI and PET studies in healthy subjects suggest a major role of the insular cortex, especially the right, in cardiac regulation. Our finding underlines the predominance of the right insula in cardiac control, which already seems to be present in children.

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Section: Discussionmentioning

confidence: 67%

Ictal bradycardia in a young child with focal cortical dysplasia in the right insular cortex

Seeck¹,

Zaim

Chaves-Vischer

et al. 2003

European Journal of Paediatric Neurology

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“…These cardiac manifestations of seizures have been considered as possible causes of SUDEP. Some of these pre-ictal modifications of cardiac activity, determined by cardiovascular and cardiorespiratory reflexes under the influence of autonomic nervous system, could be used as markers of seizure onset [13] and could provide important information regarding seizure progression and outcome [14].…”

Section: Introductionmentioning

confidence: 99%

Cortical lateralization and cardiac autonomic control. Insights from insular stroke and epilepsy

Constantinescu¹,

Detante²,

Matei³

et al. 2017

Arch Clin Cases

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Autonomic nervous system dysfunction is a common complication of stroke. Human studies and experimental data showed a hemispheric lateralization of autonomic activity concerning the forebrain and particularly the insular cortex. Insular cortex involvement is associated with more pronounced autonomic imbalance leading to life threatening arrhythmias and sudden death. We present two case reports of insular infarction in young patients without any cardiac comorbidity, illustrating a specific lateralized function of insula and its influence on the sympatho-vagal balance that implied differentiated therapeutic management after stroke. The right insular stroke was associated to sympathetic activation and left insular stroke was associated to parasympathetic predominance. The same lateralization of autonomic function with opposite effects on sympatho-vagal balance was also reported in two insular epilepsy cases, illustrating the fact that, beyond the controlling network, the cortical modulation of the autonomic nervous system is asymmetric. Identifying high risk patients prone to develop neurogenic cardiac complications, by better understanding of dysautonomia pathophysiology and consequent implementation of prophylactic and therapeutic interventions may significantly reduce mortality rate in stroke and epilepsy.

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“…Bunlar deÛißen kalp ritmi, santral apne ve beyin aktivitelerinde durma ßeklinde sÝralanmÝßtÝr. Epileptik hastalarda son zamanlarda atak esnasÝnda kardiyopulmoner deÛißkenlerin monitorizasyonu saÛlanarak elde edilen verilere gšre atak esnasÝnda sÝklÝkla taßikardi olußtuÛu bildirilmektedir (34,35). Bazen de nšbet esnasÝnda solunumun aniden durmasÝ ve buna baÛlÝ bradikardi gelißimi de sÝklÝkla gšrŸldŸÛŸ bildirilen durumlardandÝr.…”

Section: Mekanüzmaunclassified

Epileptik Hastalarda Ani ve Beklenmedik Ölümlere Adli Tıp Yaklaşımı

Özer¹,

Dokgöz²

2004

Bull Leg Med

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Epileptik hastanÝn tanÝk olunmuß veya olunmamÝß ani, beklenmedik bir bi•imde travma ve suda boÛulma ve status epileptikus dÝßÝ šlŸmŸ ve postmortem incelemede šlŸm nedenine a•ÝklÝk getirecek herhangi bir anatomik ve toksikolojik sebep tespit edilemediÛi durumlar epileptik hastalarda ani beklenmedik šlŸm (EHAB…) olarak deÛerlendirilmektedir.EHAB…, uzun zamandÝr bilinmekte fakat epilepsili hastalardaki artmÝß mortalite her zaman kabul edilmemektedir. 1960'lÝ yÝl-larda epilepsi hastasÝnÝn epileptik olmayan kadar uzun yaßamama-sÝna hi•bir neden olmadÝÛÝ dŸßŸnŸlmekteydi. EHAB…, hala geniß •apta kabul gšrmemekte ve bu yŸzden risk faktšrlerini belirlemeye yšnelik epidemiyolojik •alÝßmalar bu gibi engellere takÝlmakta-dÝr. Epileptik hastadaki ani šlŸm riskinin epileptik olmayan birine gšre yaklaßÝk 24 kat fazla olduÛu bildirilmektedir.EHAB…, yŸzyÝlÝn sonlarÝna doÛru bildirilmißse de bu fenomenin insidansÝ ve patofizyolojisi tam olarak henŸz anlaßÝlama-mÝßtÝr. EHAB… insidansÝ, olasÝ mekanizmalar, potansiyel risk faktšrleri ve araßtÝrma yšntemleri derlenerek Ÿlkemizdeki adli tÝp uygulamalarÝ a•ÝsÝndan konu irdelenmißtir.Anahtar Kelimeler: Epilepsi, ani beklenmedik šlŸm, adli tÝp. SUMMARYSudden unexpected death in epilepsy (SUDEP) is defined as sudden, unexpected, witnessed or unwitnessed, non-traumatic and non-drowning death in patients with epilepsy, with or without evidence for a seizure and excluding documented status epilepticus, in which post-mortem examination does not reveal a toxicological or anatomical cause for death. SUDEP has long been recognised although excess mortality in epilepsy has not always been accepted. In the 1960Õs it was suggested that there is no reason why an epileptic should not live as long as one who did not have epilepsy. SUDEP's occurrence is still not widely recognised and epidemiological studies to evaluate risk factors are fraught with problems. It has been estimated that the risk of sudden death for someone with epilepsy is almost 24 times higher than for someone without epilepsy.Although SUDEP has been reported since the turn of the century, the incidence and pathophysiology of this phenomenon are not well understood. The incidence of SUDEP, possible mechanisms involved, potential risk factors and current research strategies are reviewed and examined with a perspective of forensic science practice in our country.

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Electrocardiographic Accompaniments of Temporal Lobe Epileptic Seizures

Cited by 251 publications

References 25 publications

Ictal bradycardia in a young child with focal cortical dysplasia in the right insular cortex

Ictal bradycardia in a young child with focal cortical dysplasia in the right insular cortex

Cortical lateralization and cardiac autonomic control. Insights from insular stroke and epilepsy

Epileptik Hastalarda Ani ve Beklenmedik Ölümlere Adli Tıp Yaklaşımı

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