Electroanalytical Performance of a Carbon Paste Electrode Modified by Coffee Husks for the Quantification of Acetaminophen in Quality Control of Commercialized Pharmaceutical Tablets

Abstract

Electrochemical determination of acetaminophen (APAP) was successfully performed using a carbon paste electrode (CPE) modified with coffee husks (CH-CPE). Scanning electron microscopy (SEM) and SEM-energy dispersive X-ray spectroscopy (SEM-EDX) were, respectively, used for the morphological and elemental characterization of coffee husks prior to their utilization. The electrochemical oxidation of APAP was investigated by cyclic voltammetry (CV), differential pulse voltammetry (DPV), and square wave voltammetry (SWV). SWV technique appeared to be more sensitive since the oxidation current of APAP was twofold higher with the CH-CPE sensor than with the bare CPE, in relation to the increase in the organophilic character of the electrode surface. Furthermore, on CH-CPE, the current response of APAP varied linearly with its concentration in the range of 6.6 μM to 0.5 mM, leading to a detection limit of 0.66 μM (S/N=3). Finally, the proposed CH-CPE sensor was successfully used to determine the amount of APAP in commercialized tablets (Doliprane® 500 and Doliprane 1000), with a recovery rate ranging from 98% to 103%. This novel sensor opens the way for the development of low-cost and reliable devices for the electroanalysis of pharmaceutical formulations in developing countries.

Comparative assessment of methylene blue biosorption using coffee husks and corn cobs: towards the elaboration of a lignocellulosic-based amperometric sensor

“…10). The difference observed between peak currents is due to the presence of CHs which increase the real surface area and improve the hydrophilic character of the modified electrode as previously demonstrated [57,58]. In addition, CHs are mainly constituted of cellulose that having hydrophilic character could easily interact with MB which is also a hydrophilic molecule [57].…”

Direct and simultaneous quantification of rutin and quercetin in natural fruits base on purified Arabic Gum modified carbon paste electrode

“…In fact, in comparison with the unmodified electrode, the gains in intensities were evaluated to be 2 for both QT and RT on RAG-CPE, 2.8 and 3.3 for QT and RT respectively on PAG-CPE. These results can be explained by the fact that, the presence of Arabic gum in the carbon paste increases both the real surface area and the hydrophilicity of the modified CPE as shown in our previous work [17]. Moreover, the purification of Arabic gum could liberated the OH groups present at their surface, which become more available to interact with OH functional groups of flavonoids by increasing their diffusion and therefore the current peak intensities.…”

“…The surface exposed to the solution was polished on a weighing paper to give a smooth aspect before use. Purified Arabic gum modified carbon paste electrodes (PAG-CPE) was prepared as described in [17] for the bare CPE using 65 mg of graphite powder, 30 mg of silicon oil and 5 mg of pure gum powder. When not in use, CPEs were removed from the supporting electrolyte and stored at room temperature.…”

“…Another absorption peak at 1244.77 cm −1 could be attributed to C-O, C-H or C-C stretching vibrations of carboxyl groups (-COOH). The peaks at 1037.66 cm −1 is probably due to the stretching vibrations of C-O of the alcohol on the glycosyl group [17]. The region below 1000 cm −1 is the fingerprint zone and the absorption cannot clearly be assigned to any particular vibration because they correspond to complex interacting vibration systems [19].…”

Design of a Sensitive and Selective Voltammetric Sensor Based on a Cationic Surfactant-Modified Carbon Paste Electrode for the Determination of Alloxan

“…The surface of the BCPE is predominant with graphite flakes, which is more permeable for adsorption of the surfactant. 26 The surface modification was successfully established in the CTABMCPE proving the development of active sites, which fills the space between graphite flakes due to adsorption of the surfactant on the surface of the carbon paste electrode.…”