Electroanalytical determination of sulfasalazine in pharmaceutical and biological samples using molecularly imprinted polymer modified carbon paste electrode

Sadeghi, Susan; Motaharian, Ali; Moghaddam, Ali Zeraatkar

doi:10.1016/j.snb.2012.04.031

Cited by 77 publications

(34 citation statements)

References 43 publications

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“…The tolerance limit was considered as the interferent concentration that caused an approximately 5% relative error in the current signal for reduction of SAs. [41][42][43] If the coexisting interferents made the detection current signal deviation below 5% under the sufferable coexisting amount, the tested substances were believed that they almost have no interference for the experiment. The results (Tables 1-4) showed that 200-fold of glucose, sucrose, ascorbic acid; and 300-fold of KCl, NaCl, CaCl 2 , NH 4 Cl and MgSO 4 did not significantly affect the oxidation peak currents of SAs.…”

Section: Interference Of Coexisted Substancesmentioning

confidence: 99%

Voltammetric Determination of Sulfonamides with a Modified Glassy Carbon Electrode Using Carboxyl Multiwalled Carbon Nanotubes

Chen

2016

Journal of the Brazilian Chemical Society

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New glassy carbon electrode (GCE) modified with carboxyl multiwalled carbon nanotubes (MWCNTs) and treated with ultrasonic dispersing in N,N-dimethylfomamide (DMF) media, namely DMF/carboxyl/MWCNTs/GCE, was prepared for electrochemical determination of sulfonamides (SAs). Electrochemical behavior of SAs based on DMF/carboxyl/MWCNTs/GCE was investigated by cyclic voltammetry and impedance spectroscopy. The effects of various experimental parameters on the response of electrode such as pH of buffer, scan rate and the amount of modification were optimized. Under the optimal conditions, the obtained sensor presented linear response to SAs in the range of 5.0 × 10 −7 to 1.1 × 10 −4 mol L −1 of sulfonamide (R = 0.999), sulfamethazine (R = 0.990), sulfadiazine (R = 0.997), sulfamethoxazole (R = 0.996) and the limits of detection of 1. 65 × 10 −8 , 3.19 × 10 −8 , 6.76 × 10 −8 and 9.41 × 10 −8 mol L −1 , respectively. The recoveries were in the range of ca. 85-103% with relative standard deviation (RSD) < 5%. The sensor was tested by cyclic voltammetry with repeatability and stability of more than 90% of its original activity. The proposed method might offer feasibility and applicability of the sensor for further complex sulfonamides compounds.Keywords: voltammetric determination, carboxyl, multiwalled carbon nanotubes, sulfamethazine, sulfamethoxazole Introduction Sulfonamides (SAs) have a broad spectrum of antibacterial activity and play an important role as effective chemotherapeutics in bacterial. The structures of SAs consist of benzene ring with amine group (NH 2 ) at a C4 position and sulfonic acid with different alkyl groups (Figure 1). They are widely used in animal husbandry with the purpose to prevent the growth of bacteria, to treat the infections from certain protozoa and microorganisms 1,2 and to increase their production.3 As an additive of preventing bacterial in animal feed, 4 SAs, however, would bring potential consequences with unauthorized use.3 The drug residues in foods, such as milk and meat, may cause allergic reactions, antibiotic resistance and even cancer. Many countries including China have established maximum residue limits (MRLs) for SAs at the total level of 100 μg kg −1 in animal meat. 5Consequently, it is of grave importance to develop a rapid, sensitive, and accurate method for monitoring the level of SAs residues in animal meat.Currently, various methods, such as liquid chromatography, 6-12 capillary electrophoresis, 13-16 gas chromatography (GC), 17-19 micellar electrokinetic capillary chromatography, [19][20][21][22] and liquid mass chromatography, 23,24 have been proposed for analyzing SAs residue in food. These techniques have been proved to be suitable and sensitive for SAs detection. Nonetheless, some of these methods are expensive, time-consuming and tedious, and in some cases the limits of detection is not acceptable. Recently, a research on high-performance liquid chromatography (HPLC), which was coupled with photodiode array detector and mass spectrometry, studied for the...

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Section: Interference Of Coexisted Substancesmentioning

confidence: 99%

Voltammetric Determination of Sulfonamides with a Modified Glassy Carbon Electrode Using Carboxyl Multiwalled Carbon Nanotubes

Chen

2016

Journal of the Brazilian Chemical Society

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“…The precipitated proteins were separated by some sorts of mellow shake. Then, 0.5 mL of the clear supernatant was transferred into a 5 mL volumetric flask and was spiked with PTZ solution [28].…”

Section: Sample Preparation In Biological Matricesmentioning

confidence: 99%

“…MIPs afford the creation of specific recognition sites in synthetic polymers with molecular recognition properties which are formed during the polymerization process [28]. MIPs are widely used in material separation, solid-phase extraction , drug release, reaction catalysts, enzyme mimics and sensors [29][30][31].…”

Section: Introductionmentioning

confidence: 99%

Electrochemical preparation of a molecularly imprinted polypyrrole modified pencil graphite electrode for the determination of phenothiazine in model and real biological samples

Nezhadali

Rouki

Nezhadali

2015

Talanta

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“…Sulfasalazine was also determined in pharmaceutical and biological samples using molecularly imprinted polymer modified carbon paste electrode. Trace amount of sulfasalazine was determined by using differential pulse voltammetry method based on electrochemical reduction of sulfasalazine at the modified electrodes [8]. An analytical method based on capillary electrophoresis and tandem mass spectrometry was proposed and validated for the identification and simultaneous quantification of 12 sulfonamides including sulfasalazine in pork meat [9].…”

Section: Introductionmentioning

confidence: 99%

TLC—Densitometric Determination of Sulfasalazine and Its Possible Impurities in Pharmaceutical Preparations

Kwiecień

Piątek

Żmudzki

et al. 2015

Acta Chromatographica

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Summary.A simple, selective, and sensitive thin-layer chromatographic-densitometric method has been developed for the determination of sulfasalazine besides its possible impurities in pharmaceutical preparations. The mobile phase was composed of ethyl acetate-methanol-ammonia 25% 10:7:3 (v/v/v), and the stationary phase was aluminum plates precoated with silica gel 60 F 254 that enabled to obtain well resolved peaks of sulfasalazine and its impurities. The developed chromatograms were analyzed densitometrically at λ = 360 nm. R F values and ultraviolet (UV) spectra were used to identify the compounds. The developed method is highly sensitive (limit of detection [LOD] = 17.11 ng spot −1 , limit of quantitation [LOQ] = 51.84 ng spot −1 ), precise (relative standard deviation [RSD] = 1.43%-4.28%), and accurate (RSD = 1.64%-4.27%). The linearity of the method was checked within the range 20-120 ng spot −1 . The method was successfully applied for the determination of sulfasalazine in pharmaceutical preparations besides its impurities. The structures of impurities present in the standard substance and in pharmaceutical preparations were established by ultra-performance liquid chromatographytandem mass spectrometry (UPLC-MS/MS) technique.

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Electroanalytical determination of sulfasalazine in pharmaceutical and biological samples using molecularly imprinted polymer modified carbon paste electrode

Cited by 77 publications

References 43 publications

Voltammetric Determination of Sulfonamides with a Modified Glassy Carbon Electrode Using Carboxyl Multiwalled Carbon Nanotubes

Voltammetric Determination of Sulfonamides with a Modified Glassy Carbon Electrode Using Carboxyl Multiwalled Carbon Nanotubes

Electrochemical preparation of a molecularly imprinted polypyrrole modified pencil graphite electrode for the determination of phenothiazine in model and real biological samples

TLC—Densitometric Determination of Sulfasalazine and Its Possible Impurities in Pharmaceutical Preparations

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