Electroacupuncture Inhibits Inflammation Reaction by Upregulating Vasoactive Intestinal Peptide in Rats with Adjuvant‐Induced Arthritis

He, Tingting; Yang, Wen‐Jia; Zhang, Shuhui; Zhang, Chunyan; Li, Lian-Bo; Chen, Yunfei

doi:10.1155/2011/290489

Cited by 38 publications

(41 citation statements)

References 44 publications

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“…ing pain [29] , rheumatoid arthritis [18] , carrageenan-induced inflammatory pain [23] , and ALS [3] . However, the mechanism underlying the effects of acupuncture remains unclear.…”

Section: Discussionmentioning

confidence: 99%

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Anti-Inflammatory Effects of Electroacupuncture in the Respiratory System of a Symptomatic Amyotrophic Lateral Sclerosis Animal Model

Jiang¹,

Yang²,

Baek³

et al. 2011

Neurodegener Dis

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Background: Because amyotrophic lateral sclerosis (ALS) is a progressive inflammatory disease, treatment of the pulmonary system plays a key role in ALS patients’ care. Previous studies have mainly examined the pathological mechanism of ALS in the central nervous system; however, there has been relatively little research regarding the pulmonary system in ALS animal models. In inflammatory diseases, including asthma and arthritis, electroacupuncture (EA) is commonly used for its anti-inflammatory effects. The goal of this study was to determine whether EA treatment affects inflammation in the pulmonary system in an ALS animal model. Methods: EA treatment at ST36 (Zusanli) acupoint was performed with 14-week-old hSOD1^G93A transgenic mice. Immunohistochemical analysis was performed using anti-ionized calcium binding adaptor molecule 1 (Iba-1) and anti-tumor necrosis factor alpha (TNF-α) antibodies. To investigate the expression level of inflammatory proteins, Western blot analyses were performed using anti-Iba-1, anti-TNF-α, anti-nuclear factor kappa B (NF-ĸB), and anti-interleukin 6 (IL-6) antibodies. The activation of Ser435-phospho-specific RAC-alpha serine/threonine-protein kinase 1 (pAKT) and the increase of phosphorylated extracellular-signal-regulated kinases (pERK) protein in lung tissues of EA-treated and untreated hSOD1^G93A mice were also evaluated by Western blot. Results: EA treatment decreased the expression of the proinflammatory proteins such as TNF-α and IL-6, pNF-ĸB, and Iba-1 and increased the level of activated pAKT and pERK compared to control hSOD1^G93A mice. Conclusions: Our findings suggest that EA could be an effective anti-inflammatory treatment for the respiratory impairment that occurs in ALS animal models.

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“…ing pain [29] , rheumatoid arthritis [18] , carrageenan-induced inflammatory pain [23] , and ALS [3] . However, the mechanism underlying the effects of acupuncture remains unclear.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have demonstrated the effectiveness of acupuncture in treating inflammatory diseases (i.e. rheumatoid arthritis) [18] and neurodegenerative diseases including Alzheimer's disease [19] , Parkinson's disease [20] and ALS [3] . However, the molecular mechanisms underlying the effectiveness of acupuncture remain unclear.…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory Effects of Electroacupuncture in the Respiratory System of a Symptomatic Amyotrophic Lateral Sclerosis Animal Model

Jiang¹,

Yang²,

Baek³

et al. 2011

Neurodegener Dis

View full text Add to dashboard Cite

show abstract

“…Acupuncture also appears to affect the immune system and therefore can have a direct effect on inflammation [18, 19], including reducing neutrophil invasion during sepsis [20]. The role of inflammation in carcinogenesis has been extensively investigated and well documented [21–23].…”

Section: Introductionmentioning

confidence: 99%

Effects of Different Electroacupuncture Scheduling Regimens on Murine Bone Tumor-Induced Hyperalgesia: Sex Differences and Role of Inflammation

Smeester

Al-Gizawiy

Beitz

2012

Evidence-Based Complementary and Alternative Medicine

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Previous studies have shown that electroacupuncture (EA) is able to reduce hyperalgesia in rodent models of persistent pain, but very little is known about the analgesic effects and potential sex differences of different EA treatment regimens. In the present study, we examined the effects of five different EA treatments on tumor-induced hyperalgesia in male and female mice. EA applied to the ST-36 acupoint either twice weekly (EA-2X/3) beginning on postimplantation day (PID) 3 or prophylactically three times prior to implantation produced the most robust and longest lasting antinociceptive effects. EA treatment given once per week beginning at PID 7 only produced an antinociceptive effect in female animals. The analgesic effect of EA-2X/3 began earlier in males, but lasted longer in females indicating sex differences in EA. We further demonstrate that EA-2X/3 elicits a marked decrease in tumor-associated inflammation as evidenced by a significant reduction in tumor-associated neutrophils at PID 7. Moreover, EA-2X/3 produced a significant reduction in tumor-associated PGE2 as measured in microperfusate samples. Collectively, these data provide evidence that EA-2X/3 treatment reduces tumor-induced hyperalgesia, which is associated with a decrease in tumor-associated inflammation and PGE2 concentration at the tumor site suggesting possible mechanisms by which EA reduces tumor nociception.

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“…Continuous-wave stimulation was selected at a frequency of 5 Hz and intensity of 2 mA (6805-AII, Shantou Medical Equipment Factory Co., Ltd.) [27–29]. An individual EA session was administered daily for 20 min for 7 days, with 2-day rest for the course of treatment, for 4 consecutive weeks.…”

Section: Methodsmentioning

confidence: 99%

In VivoDetection of the Effect of Electroacupuncture on “Zusanli” Acupoint in Rats with Adjuvant-Induced Arthritis through Optical Coherence Tomography

Zhong

Yang

Zhou

et al. 2016

BioMed Research International

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This study aimed to investigate the effect of electroacupuncture (EA) treatment through optical coherence tomography (OCT) in vivo on rats with adjuvant-induced arthritis. OCT images were obtained from the ankle of the right hind paws of the rats in control, model, and EA groups before modelling and 1 day, 8 days, 15 days, 22 days, and 29 days after modelling. Results demonstrated that the OCT signal of the ankle of the right hind paws of the rats was indistinct compared to 1 day after modelling and before modelling in the EA group. In the EA group, the light averaged attenuation coefficients of the ankle tissues decreased as treatment duration was prolonged after EA was administered (3.43, 2.96, 2.61, 2.42, and 2.29 mm−1, resp.). There was a significant difference in attenuation coefficient decrease between the 29th d and the 1st d for EA group compared with control group (P < 0.01). This condition indicated that the light absorption of the ankle of the treated rats in the EA group decreased. Therefore, OCT can be used to monitor the effect of treatment on rats with arthritis in vivo.

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Electroacupuncture Inhibits Inflammation Reaction by Upregulating Vasoactive Intestinal Peptide in Rats with Adjuvant‐Induced Arthritis

Cited by 38 publications

References 44 publications

Anti-Inflammatory Effects of Electroacupuncture in the Respiratory System of a Symptomatic Amyotrophic Lateral Sclerosis Animal Model

Anti-Inflammatory Effects of Electroacupuncture in the Respiratory System of a Symptomatic Amyotrophic Lateral Sclerosis Animal Model

Effects of Different Electroacupuncture Scheduling Regimens on Murine Bone Tumor-Induced Hyperalgesia: Sex Differences and Role of Inflammation

In VivoDetection of the Effect of Electroacupuncture on “Zusanli” Acupoint in Rats with Adjuvant-Induced Arthritis through Optical Coherence Tomography

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