Electroacupuncture inhibits hippocampal neuronal apoptosis and improves cognitive dysfunction in mice with vascular dementia via the JNK signaling pathway

Liu, Yaru; Yan, Zhenyang; Ren, Yafei; Wang, Woyu; Ke, Yinze; Wang, Yifan; Qi, Rongming

doi:10.1177/09645284221136878

Cited by 3 publications

(3 citation statements)

References 51 publications

(74 reference statements)

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“…It is suggested that p53 and its downstream products may be another potential target for acupuncture to inhibit apoptosis and improve PSCI. EA can also upregulate the protein and mRNA expressions of Bcl-2, inhibit activator protein (AP)-1, p53, and Bax, alleviate the apoptosis of hippocampal cells in rats induced by modified bilateral common carotid artery occlusion (BCCAO), and improve their cognitive impairment, which may be related to the inhibition of JNK signaling pathway ( Liu et al, 2022 ). The process of apoptosis is highly controlled by various intracellular pathways, including nuclear factors-κB (NF-κB) Signal conduction.…”

Section: Resultsmentioning

confidence: 99%

The effects and mechanisms of acupuncture for post-stroke cognitive impairment: progress and prospects

Wang

Liu³

et al. 2023

Front. Neurosci.

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Stroke is one of the important causes of both disability and death worldwide, which is very common in older adults. Post-stroke cognitive impairment (PSCI) is a common secondary damage of stroke, which is the main cause of long-term disability and decreased quality of life in stroke patients, which brings a heavy burden to society and families. Acupuncture, as one of the oldest and widely used worldwide techniques in Chinese medicine, is recommended by the World Health Organization (WHO) as an alternative and complementary strategy for improving stroke care. This review comprehensively summarizes literature from the last 25 years, showing that acupuncture can exert strong beneficial effect on PSCI. The mechanisms of acupuncture on PSCI involves anti-neuronal apoptosis, promoting synaptic plasticity, alleviating central and peripheral inflammatory reactions, and regulating brain energy metabolism disorders (including improving cerebral blood flow, glucose utilization and mitochondrial structure and function, etc.), etc. The effects and mechanisms of acupuncture on PSCI reviewed in this study provides scientific and reliable evidence for acupuncture application for PSCI.

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Section: Resultsmentioning

confidence: 99%

The effects and mechanisms of acupuncture for post-stroke cognitive impairment: progress and prospects

Wang

Liu³

et al. 2023

Front. Neurosci.

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“…It can also be damaged after stroke, resulting in cognitive dysfunction [ 29 ]. Research conducted by Yaru Liu and colleagues demonstrated that electroacupuncture may improve cognitive impairment caused by vascular dementia by inhibiting the JNK signaling pathway and reducing apoptosis in the hippocampus [ 30 ]. Additionally, through behavioral testing and proteomic analysis, Sa and colleagues found that electroacupuncture can improve the proteome in the hippocampal region of rats with cognitive impairment, which is associated with the upregulation of heat shock proteins in the brain via electroacupuncture treatment [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Electroacupuncture improves the learning and memory abilities of rats with PSCI by attenuating the TLR4/NF-κB/NLRP3 signaling pathway on the hippocampal microglia

Bian,

Liu,

et al. 2024

NeuroReport

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This study aims to investigate how electroacupuncture regulates the learning and memory abilities of poststroke cognitive impairment (PSCI) rats through the TLR4/NF-κB/NLRP3 signaling pathway on the hippocampal microglia. Thirty male rats were randomly divided into three groups: sham surgery group, PSCI model group, and electroacupuncture group, with 10 rats in each group. Middle cerebral artery occlusion was used to establish the PSCI model. The Zea Longa method was used to score the rats’ neurological function. Electroacupuncture was utilized for 21 days to improve PSCI. The learning and memory abilities of rats were tested using the Morris water maze. Hematoxylin–eosin staining and immunofluorescence were used to find the hippocampus’ pathological changes. The concentration of interleukin-1β, interleukin-6, tumor necrosis factor-α, and interleukin-18 were detected by ELISA. The mRNA expression levels of associated inflammatory corpuscles were measured by quantitative real-time PCR. The protein expression levels of TLR4, MyD88, NF-κB, and NLRP3 were measured using western blotting. Electroacupuncture improved not only the learning and memory abilities of PSCI rats but also hippocampal morphology. Electroacupuncture inhibited the activation of microglia and the TLR4/NF-κB/NLRP3 signaling pathway. Electroacupuncture also reduced proinflammatory factors and restrained the mRNA levels of NLRP3-associated inflammatory cytokines. Its mechanism was related to inhibiting the expression of the TLR4/NF-κB/NLRP3 signaling pathway, attenuating the release of inflammatory factors, and regulating the activation of hippocampal microglia in the brain.

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“…Bcl-2, Bax, and Casp3 can inhibit or promote the apoptosis of neurons; therefore, the regulation of neuronal apoptosis-related factors has a certain effect on VD control. Some studies have also proved that TCM therapy can play a role in the anti-apoptosis of nerve cells by regulating levels of Bcl-2, Bax, and other factors related to nerve apoptosis (13). Nevertheless, there is no clinical study about the influence of Shibing Xingnao Granules on factors related to nerve apoptosis.…”

Section: Clinical Effect Of Shibing Xingnao Granules On Vascular Deme...mentioning

confidence: 99%

Clinical effect of Shibing Xingnao granules on vascular dementia patients and its effect on serum neuronal apoptosis molecules

Liu¹,

Liu²,

Peng³

et al. 2023

Cell Mol Biol (Noisy-le-grand)

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Electroacupuncture inhibits hippocampal neuronal apoptosis and improves cognitive dysfunction in mice with vascular dementia via the JNK signaling pathway

Cited by 3 publications

References 51 publications

The effects and mechanisms of acupuncture for post-stroke cognitive impairment: progress and prospects

The effects and mechanisms of acupuncture for post-stroke cognitive impairment: progress and prospects

Electroacupuncture improves the learning and memory abilities of rats with PSCI by attenuating the TLR4/NF-κB/NLRP3 signaling pathway on the hippocampal microglia

Clinical effect of Shibing Xingnao granules on vascular dementia patients and its effect on serum neuronal apoptosis molecules

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