Electroacupuncture improves gut barrier dysfunction in prolonged hemorrhagic shock rats through vagus anti-inflammatory mechanism

Du, Ming-Hua

doi:10.3748/wjg.v19.i36.5988

Cited by 56 publications

(45 citation statements)

References 38 publications

(47 reference statements)

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“…Data indicate that either auricular electrostimulation[111], acupuncture[112, 113] or electroacupuncture[114] on ST36 can attenuate serum concentrations of inflammatory cytokines TNF, IL-1β and IL-6, as well as improve kidney and lung injury in septic rodents. These mechanisms are not specific to sepsis, and electroacupuncture on ST36 can also prevent intestinal injury in ischemic and hemorrhagic rodents [115]. Mechanistically, these effects were reported to occur via the vagus nerve as they were prevented by surgical vagotomy [2, 116].…”

Section: Neuro-immunomodulation and Functional Organization Of The Nementioning

confidence: 99%

Nerve Stimulation: Immunomodulation and Control of Inflammation

Ulloa

Quiróz-González

Torres‐Rosas

2017

Trends in Molecular Medicine

126

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Neuronal stimulation is an emerging field in modern medicine to control organ function and reestablish physiological homeostasis during illness. Transdermal nerve stimulation with electroacupuncture is currently endorsed by the WHO, the NIH, and is used by millions of people to control pain and inflammation. Recent advances in electroacupuncture might allow the activation of specific neuronal networks to prevent organ damage in inflammatory and infectious disorders. Experimental studies of nerve stimulation are also providing new information on the functional organization of the nervous system to control inflammation and its clinical implications in infectious and inflammatory disorders. These studies might allow the design of novel non-invasive techniques for nerve stimulation to help control immune and organ functions.

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Section: Neuro-immunomodulation and Functional Organization Of The Nementioning

confidence: 99%

Nerve Stimulation: Immunomodulation and Control of Inflammation

Ulloa

Quiróz-González

Torres‐Rosas

2017

Trends in Molecular Medicine

126

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“…The authors concluded that EA combined with delayed fluid replacement was protective against hepatic ischemia in rats following HS. These results alongside the results from their later study (Du et al 2013), which includes data from a control group that underwent vagotomy before EA, indicate that EA at ST36, even though not directly stimulating the vagus nerve, does act, at least partially, through the vagal signaling pathway.…”

Section: Electroacupuncturementioning

confidence: 55%

“…The effects of EA at ST36 to decrease gut barrier dysfunction have also been investigated (Du et al 2013). In a study by Du et al, a wider range of biological markers, including MAP, interleukin-6, interleukin-10, TNFor-α organ parameters, gut injury score, gut permeability to 4 kDa FITC-dextran, and expression and distribution of tight junction protein ZO-1, as well as simple survival counts, were investigated.…”

Section: Electroacupuncturementioning

confidence: 99%

Neuromodulation as a new avenue for resuscitation in hemorrhagic shock

et al. 2019

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Hemorrhagic shock (HS), a major cause of early death from trauma, accounts for around 40% of mortality, with 33-56% of these deaths occurring before the patient reaches a medical facility. Intravenous fluid therapy and blood transfusions are the cornerstone of treating HS. However, these options may not be available soon after the injury, resulting in death or a poorer quality of survival. Therefore, new strategies are needed to manage HS patients before they can receive definitive care. Recently, various forms of neuromodulation have been investigated as possible supplementary treatments for HS in the prehospital phase of care. Here, we provide an overview of neuromodulation methods that show promise to treat HS, such as vagus nerve stimulation, electroacupuncture, trigeminal nerve stimulation, and phrenic nerve stimulation and outline their possible mechanisms in the treatment of HS. Although all of these approaches are only validated in the preclinical models of HS and are yet to be translated to clinical settings, they clearly represent a paradigm shift in the way that this deadly condition is managed in the future.

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“…As we all know, intravenous fluid resuscitation is usually difficult to administer in some environments. In recent years, we have been working on alternative methods to solve the complications caused by delayed fluid resuscitation and we have proved that EA at ST36 can significantly protect the intestinal barrier integrity and improve organ function and survival rate after fatal hemorrhagic shock in rats [7, 8]. Recent studies showed that electrical stimulation of the vagus nerve could protect alleviation of inflammatory injuries and remote organs of animals following burn injuries by activation of the cholinergic anti-inflammatory pathway [22].…”

Section: Discussionmentioning

confidence: 99%

“…Research [5, 6] indicates that EA at ST36 can promote periphery nerve endings producing acetylcholine, enhancing the activity of acetylcholine, and activating the cholinergic anti-inflammatory pathway. It has positive therapeutic implications on a series of inflammatory reactions that occur during shock, protecting the functions of organs of the body after shock [7]. One of our previous studies [8] showed that the ST36 acupuncture point improved rehydration and rats' blood pressure levels and decreased the survival rate of rats in hemorrhagic shock.…”

Section: Introductionmentioning

confidence: 99%

Heart Protective Effects of Electroacupuncture in an Animal Experimental Study with Delayed Fluid Resuscitation after Hemorrhagic Shock

Wang

Liu

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Fluid resuscitation could hardly be performed immediately after fatal hemorrhagic shock in outpatients. We investigated whether electroacupuncture (EA) at Zusanli (ST36) could prevent fatal hemorrhagic shock induced heart failure with delayed fluid resuscitation and whether the protective role of EA is related to the autonomic nervous system. Sixty Sprague Dawley rats were randomly divided into five groups (n = 12 each): group of sham hemorrhagic shock (SHAM), group of EA, group of sham EA (SEA), group of delayed fluid resuscitation with EA (EA + DR), and group of delayed fluid resuscitation with SEA (SEA + DR). After blood loss for 6 hours, caspase-3 activity and positive rate of TUNEL in EA + DR group were significantly lower than in other hemorrhagic shock groups (e.g., versus SEA + DR: 0.156 ± 0.039 versus 0.301 ± 0.042; P < 0.05). Immediately EA treatment after the blood loss enhanced the protective effect of delayed resuscitation on the cardiac tissue of hemorrhagic shock rats. Considering the significant changes of epinephrine (137.8 ± 6.9 ng/L versus 98.6 ± 7.4 ng/L; P < 0.05) and acetylcholine (405 ± 8.6 pmol/L versus 341 ± 10.1 pmol/L; P < 0.05) after EA treatment (SEA + DR versus EA + DR), this cardiac protective effect may be related to regulation of the autonomic nervous system.

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Electroacupuncture improves gut barrier dysfunction in prolonged hemorrhagic shock rats through vagus anti-inflammatory mechanism

Abstract: EA at ST36 attenuates the systemic inflammatory response, protects intestinal barrier integrity, improves organ function and survival rate after hemorrhagic shock via activating the cholinergic anti-inflammatory mechanism.

Cited by 56 publications

References 38 publications

Nerve Stimulation: Immunomodulation and Control of Inflammation

Nerve Stimulation: Immunomodulation and Control of Inflammation

Neuromodulation as a new avenue for resuscitation in hemorrhagic shock

Heart Protective Effects of Electroacupuncture in an Animal Experimental Study with Delayed Fluid Resuscitation after Hemorrhagic Shock

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