Electroacupuncture improves cerebral blood flow and attenuates moderate ischemic injury via Angiotensin II its receptors-mediated mechanism in rats

Li, Jing; He, Jiao-Jun; Du, Yiqi; Cui, Jingjun; Ma, Ying; Zhang, Xuezhu

doi:10.1186/1472-6882-14-441

Cited by 42 publications

(29 citation statements)

References 42 publications

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“…Under normal conditions, electroacupuncture-induced changes in the IP 3 level in rat brain and spinal cord, suggesting links to the PI system via its signal transduction pathways. In mild cerebral artery occlusion, acupuncture was shown to downregulate the significant increases in expression of Angiotensin II and influence its receptor-mediated phosphatidyl inositol signal pathway, consequently reducing vasoconstriction and improving blood supply to the ischemic region, and ultimately conferring beneficial effects on cerebral ischemia 28 . In addition, acupuncture has been shown to effectively inhibit cerebral ischemia-induced increased levels of intracellular IP 3 and diacylglycerol (DAG) in rat cerebral arteries, which may contribute to acupuncture’s effect in modulating vascular constriction and dilation to ameliorate cerebral microcirculation 29 .…”

Section: Discussionmentioning

confidence: 99%

A Targeted Metabolomics MRM-MS Study on Identifying Potential Hypertension Biomarkers in Human Plasma and Evaluating Acupuncture Effects

Yang

Zheng

Deng

et al. 2016

Sci Rep

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The critical role of metabolic abnormality in hypertension is increasingly recognized, but its biomarkers are not clearly identified. In this study, 47 chemical compounds recorded by literature were employed as target metabolites of essential hypertension (EH). We detected their content in the plasma of EH patients and healthy subjects by using the Multiple Reaction Monitoring-Mass Spectrometry (MRM-MS). After screening the most altered compounds, acupuncture was used to treat patients for 3 months and these plasma metabolites were tested again. The results showed that oleic acid (OA) and myoinositol (MI) were the most important differential metabolites between the hypertensive plasma and the healthy plasma. They were also closely correlated with 24-hour blood pressure and nocturnal dipping. Moreover, plasma OA and MI could be restored to normal levels by acupuncture, accompanying with reduction of 24-hour systolic and diastolic blood pressure [from 145.10 ± 9.28 mm Hg to 140.70 ± 9.59 mm Hg (P < 0.0001), and 88.35 ± 7.92 mm Hg to 85.86 ± 7.95 mm Hg (P = 0.0024), respectively] and improvement of circadian blood pressure rhythm. This study demonstrated that plasma OA and MI were potential hypertension biomarkers and they could be used to preliminarily assess the treating effects such as acupuncture.

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Section: Discussionmentioning

confidence: 99%

A Targeted Metabolomics MRM-MS Study on Identifying Potential Hypertension Biomarkers in Human Plasma and Evaluating Acupuncture Effects

Yang

Zheng

Deng

et al. 2016

Sci Rep

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“…EA can also decrease the expression of angiotensin II and its type 1 receptor (AT1R), and thereby increases cerebral blood flow and vasodilation [ 32 ]. The study evidence in support of this section can be seen in the supplementary file ( Table S4 ).…”

Section: Regulation Of Cerebral Blood Flowmentioning

confidence: 99%

Mechanisms of Acupuncture Therapy in Ischemic Stroke Rehabilitation: A Literature Review of Basic Studies

Chavez

Huang

MacDonald

et al. 2017

IJMS

211

181

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Acupuncture is recommended by the World Health Organization (WHO) as an alternative and complementary strategy for stroke treatment and for improving stroke care. Clinical trial and meta-analysis findings have demonstrated the efficacy of acupuncture in improving balance function, reducing spasticity, and increasing muscle strength and general well-being post-stroke. The mechanisms underlying the beneficial effects of acupuncture in stroke rehabilitation remain unclear. The aim of this study was to conduct a literature review, summarize the current known mechanisms in ischemic stroke rehabilitation through acupuncture and electroacupuncture (EA) therapy, and to detail the frequently used acupoints implicated in these effects. The evidence in this review indicates that five major different mechanisms are involved in the beneficial effects of acupuncture/EA on ischemic stroke rehabilitation: (1) Promotion of neurogenesis and cell proliferation in the central nervous system (CNS); (2) Regulation of cerebral blood flow in the ischemic area; (3) Anti-apoptosis in the ischemic area; (4) Regulation of neurochemicals; and, (5) Improvement of impaired long-term potentiation (LTP) and memory after stroke. The most frequently used acupoints in basic studies include Baihui (GV20), Zusanli (ST36), Quchi (LI11), Shuigou (GV26), Dazhui (GV14), and Hegu (LI4). Our findings show that acupuncture exerts a beneficial effect on ischemic stroke through modulation of different mechanisms originating in the CNS.

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“…Collagen induced atherothrombosis [80]. Ang II was involved in apoptosis, inflammation [81], the neurological deficit score, hemorrhage volume [82], hypertrophy, and inward remodeling of cerebral arterioles [83]; after decreasing the Ang II levels, cerebral blood supply was improved [84], and ET-1 may promote the development of the stroke process [85]. ETAR and NO may be involved in the pathogenesis of cerebral vasospasm [37].…”

Section: The Potential Of Acupuncture For Secondary Prevention Of Strmentioning

confidence: 99%

Regulation of Hypertension for Secondary Prevention of Stroke: The Possible ‘Bridging Function' of Acupuncture

Zheng¹,

Han²,

Du³

et al. 2018

Complement Med Res

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Worldwide, stroke is the leading cause of mortality and disability, with hypertension being an independent risk factor for a secondary stroke. Acupuncture for the treatment of hypertension gains more attention in alternative and complementary medicine, but the results are inconsistent. Few studies regarding the secondary prevention of stroke by managing hypertension with acupuncture have been carried out as there are some problems regarding the antihypertensive drug status in the secondary prevention of stroke. Still, the potential of acupuncture in regulating the blood pressure for secondary stroke prevention deserves our focus. This review is based on papers recorded in the PubMed, Embase, and Web of Science databases, from their inception until March 28, 2017, and retrieved with the following search terms: hypertension and acupuncture, limited in spontaneously hypertensive rats (SHRs), stress-induced (or cold-induced) hypertensive or pre-hypertensive models. We find that, in these hypertensive animals, acupuncture could mainly influence factors related to the nervous system, oxidative stress, the endocrine system, cardiovascular function, and hemorheology, which are closely associated with the stroke outcome. This trend may give us a hint that acupuncture might well participate in the secondary prevention of stroke through these pathways when used in the management of hypertension.

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Electroacupuncture improves cerebral blood flow and attenuates moderate ischemic injury via Angiotensin II its receptors-mediated mechanism in rats

Cited by 42 publications

References 42 publications

A Targeted Metabolomics MRM-MS Study on Identifying Potential Hypertension Biomarkers in Human Plasma and Evaluating Acupuncture Effects

A Targeted Metabolomics MRM-MS Study on Identifying Potential Hypertension Biomarkers in Human Plasma and Evaluating Acupuncture Effects

Mechanisms of Acupuncture Therapy in Ischemic Stroke Rehabilitation: A Literature Review of Basic Studies

Regulation of Hypertension for Secondary Prevention of Stroke: The Possible ‘Bridging Function' of Acupuncture

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