Electroacupuncture could balance the gut microbiota and improve the learning and memory abilities of Alzheimer’s disease animal model

Jiang, Jing; Liu, Hao; Wang, Zidong; Tian, Huiling; Wang, Shun; Yang, Jiayi; Ren, Jingyu

doi:10.1371/journal.pone.0259530

Cited by 21 publications

(17 citation statements)

References 97 publications

(107 reference statements)

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“…Therefore, it is very important to assess whether acupuncture can alleviate NAFLD by mediating autophagy and apoptosis through related pathways. In addition, new evidence also suggests that NAFLD is closely related to intestinal flora, and acupuncture has been proved to be involved in the treatment of various diseases, including nervous system diseases, endocrine diseases, and digestive system diseases, by regulating intestinal flora [51][52][53]. The correlation between acupuncture and intestinal flora is also worth exploring.…”

Section: Discussionmentioning

confidence: 99%

Research Progress on the Mechanism of Acupuncture Treatment for Nonalcoholic Fatty Liver Disease

2022

Gastroenterology Research and Practice

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Nonalcoholic fatty liver disease (NAFLD) represents the most common chronic liver disease worldwide, ranging from simple steatosis and nonalcoholic steatohepatitis to fibrosis, cirrhosis, and hepatocellular carcinoma. Acupuncture is a long-established treatment in traditional Chinese medicine. In recent years, increasing evidence has pointed to the effectiveness of acupuncture in the treatment of NAFLD, and a certain degree of progress has been made in the study of related mechanisms. However, previous systematic reviews have not discussed the characteristics and the related mechanisms of acupuncture in the treatment of NAFLD. Therefore, this review synthesizes the progress in research on acupuncture in the context of NAFLD treatment by the inhibition of inflammatory responses, regulation of lipid metabolism disorder, treatment of insulin resistance, antagonization of oxidative stress injury, and interference with endoplasmic reticulum stress. Overall, we sought to highlight the latest research results, potential applications, and ongoing challenges of this therapy.

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Section: Discussionmentioning

confidence: 99%

Research Progress on the Mechanism of Acupuncture Treatment for Nonalcoholic Fatty Liver Disease

2022

Gastroenterology Research and Practice

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“…"Zusanli": Straight stab, 4 mm. Continuous wave, 50 Hz, 1 mA, 20 min/d, 8 weeks APP/PS1 mice MA "Baihui" (GV20), "Hegu" (LI4), "Feishu" (BL13), "Pishu" (BL20), "Shenshu" (BL23), "Zusanli" (ST36), and "Sanyinjiao" (SP6) [117] 20 min/d, 5 times/week, 4 weeks SAMP8 mice EA "Baihui" (GV20), "Yintang" (GV29) [118] Transverse puncturing, 4 ~5 mm, sparse wave, 2 Hz, 2 V, 0.1 mA, 15 min/d APP/PS1 mice EA "Baihui" (GV20) [127] Disperse waves, 1 and 20 Hz, 30 min, 5 days/week, and 2 days rest for a period of 4 weeks APP/PS1 mice EA "Baihui" (GV20), "Yintang" (GV29, "Shuigou" (GV26) [129] "Baihui": Upward oblique stab, 5 mm and "Yintang": Downward oblique stab, 5 mm. 2 Hz, 1 mA.…”

Section: Modelsmentioning

confidence: 99%

Acupuncture Interventions for Alzheimer’s Disease and Vascular Cognitive Disorders: A Review of Mechanisms

Yang

Wang

et al. 2022

Oxidative Medicine and Cellular Longevity

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Cognitive impairment (CI) related to Alzheimer’s disease (AD) and vascular cognitive disorders (VCDs) has become a key problem worldwide. Importantly, CI is a neuropsychiatric abnormality mainly characterized by learning and memory impairments. The hippocampus is an important brain region controlling learning and memory. Recent studies have highlighted the effects of acupuncture on memory deficits in AD and VCDs. By reviewing the literature published on this topic in the past five years, the present study intends to summarize the effects of acupuncture on memory impairment in AD and VCDs. Focusing on hippocampal synaptic plasticity, we reviewed the mechanisms underlying the effects of acupuncture on memory impairments through regulation of synaptic proteins, AD characteristic proteins, intestinal microbiota, neuroinflammation, microRNA expression, orexin system, energy metabolism, etc., suggesting that hippocampal synaptic plasticity may be the common as well as the core link underlying the above mechanisms. We also discussed the potential strategies to improve the effect of acupuncture. Additionally, the effects of acupuncture on synaptic plasticity through the regulation of vascular–glia–neuron unit were further discussed.

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“…GV20, GV29 increased CBF in the prefrontal lobe and hippocampus (44). by balancing the gut microbiota (45). enhanced paravascular influx in the glymphatic system inhibited the reactivity of astrocytes and improved AQP4 polarity (46).…”

Section: Sp10mentioning

confidence: 99%

Bibliometric review of 1992–2022 publications on acupuncture for cognitive impairment

Zhou

Lu²,

Xiao³

et al. 2022

Front. Neurol.

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ObjectiveTo explore the development context, research hotspots, and frontiers of acupuncture therapy for cognitive impairment (CI) from 1992 to 2022 by visualization analysis.MethodsArticles about acupuncture therapy for cognitive impairment were retrieved from the Web of Science Core Collection (WoSCC) until 1 March 2022. Basic information was collected by Excel 2007, and VOSviewer 1.6.17 was used to analyze the co-occurrence of countries, institutes, and authors. Co-citation maps of authors and references were analyzed by CiteSpace V.5.8.R3. In addition, CiteSpace was used to analyze keyword clusters and forecast research frontiers.ResultsA total of 279 articles were retrieved, including articles from 19 countries, 334 research institutes, and 101 academic journals. The most published country and institutes were the People's Republic of China (217) and the Fujian University of Traditional Chinese Medicine (40). Ronald C Petersen owned the highest co-citations (56). Keywords and co-cited references cluster showed the main research directions in this area, including “ischemic stroke,” “cerebral ischemia/reperfusion,” “mild cognitive impairment,” “Alzheimer's disease,” “vascular dementia,” “vascular cognitive impairment with no dementia,” “multi-infarct dementia,” “synaptic injury,” “functional MRI,” “glucose metabolism,” “NMDA,” “nuclear factor-kappa b pathway,” “neurotrophic factor,” “matrix metalloproteinase-2 (MMP-2),” “tumor necrosis factor-alpha,” “Bax,” “Caspase-3,” and “Noxa”. Trending keywords may indicate frontier topics, such as “randomized controlled trial,” “rat model,” and “meta-analysis.”ConclusionThis research provides valuable information for the study of acupuncture. Diseases focus on mild cognitive impairment (MCI), Alzheimer's disease (AD), and vascular dementia (VaD). Tauopathies with hyperphosphorylation of Tau protein as the main lesions also need to be paid attention to. The development of functional magnetic resonance imaging (fMRI) will better explain the therapeutic effect of acupuncture treatment. The effect of acupuncture on a single point is more convincing, and acupuncture on Baihui (GV20) may be needed in the future. Finally, the implementation of high-quality multicenter randomized controlled trials (RCTs) requires increased collaboration among experts from multiple fields and countries.

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Electroacupuncture could balance the gut microbiota and improve the learning and memory abilities of Alzheimer’s disease animal model

Cited by 21 publications

References 97 publications

Research Progress on the Mechanism of Acupuncture Treatment for Nonalcoholic Fatty Liver Disease

Research Progress on the Mechanism of Acupuncture Treatment for Nonalcoholic Fatty Liver Disease

Acupuncture Interventions for Alzheimer’s Disease and Vascular Cognitive Disorders: A Review of Mechanisms

Bibliometric review of 1992–2022 publications on acupuncture for cognitive impairment

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