Electroacupuncture combined with qibei mixture for diarrhea-predominant irritable bowel syndrome: A randomized controlled trial

Zhang, Chaoxian; Guo, Like; Wang, Yuyu; Zhang, Lili; Chang, Tingmin

doi:10.1016/j.wjam.2018.03.002

Cited by 6 publications

(13 citation statements)

References 11 publications

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“…A total of 61 RCTs 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 ,…”

Section: Resultsunclassified

“…Experimental details of clinical research are summarized in (Table S1 ). The 9,447 participants in 61 RCTs were divided as follows: 2875 with FD in 21 studies, 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 3,220 with IBS in 24 studies, 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 and 3,352 with FC in 16 studies. 54 , 55 , 56 , 57 , 58 , …”

Section: Resultsmentioning

confidence: 99%

“…A total of 13 RCTs compared AT plus active therapeutics with other active therapeutics. For the active therapeutics, eight trials 21 , 26 , 33 , 34 , 50 , 55 , 57 , 63 , 66 used Chinese herbal medicine and four studies 9 , 11 , 13 , 17 used pharmacotherapy. The pooled results (Fig.…”

Section: Resultsmentioning

confidence: 99%

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Acupuncture for functional gastrointestinal disorders: A systematic review and meta‐analysis

Wang

Guan

et al. 2021

J of Gastro and Hepatol

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Objectives:The therapeutic effect of acupuncture treatments (AT) on functional gastrointestinal disorders (FGIDs) is contentious. A meta-analysis was conducted to assess the efficacy and safety of acupuncture for FGIDs. Methods: The Cochrane Library, EMBASE, PUBMED, Web of Science, Wanfang Database, China National Knowledge Infrastructure, and VIP Database were searched through December 31, 2019 with no language restrictions. Risk ratio (RR) with 95% confidence interval (CI) was calculated to determine the improvement in symptom severity after treatment. Results: A total of 61 randomized controlled trials (RCTs) on FGIDs were included. The pooled results illustrated the following: compared to pharmacotherapy (RR 1.13, 95% CI 1.09-1.17), placebo acupuncture (RR 1.69, 95% CI 1.37-2.08), no specific treatment (RR 1.86, 95% CI 1.31-2.62), and AT as an adjuvant intervention to other active treatments (RR 1.25, 95% CI 1.21-1.30), AT had more favorable improvements in symptom severity; sub-group analysis results classified according to functional dyspepsia, irritable bowel syndrome, and functional constipation also supported this finding; and the incidence of adverse events was lower in AT than in other treatments (RR 0.75, 95% CI 0.56-0.99). Conclusions: This meta-analysis found that AT was significantly associated with relief of FGIDs symptoms; however, the evidence level was moderate or low. Further data from rigorously designed and well powered RCTs are needed to verify the effectiveness and safety of AT as a FGIDs treatment. PROSPERO PROTOCOL NUMBER: CRD42020169508. MethodsLiterature search. According to the PRISMA guidelines, 4

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Section: Resultsunclassified

Section: Resultsmentioning

confidence: 99%

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Acupuncture for functional gastrointestinal disorders: A systematic review and meta‐analysis

Wang

Guan

et al. 2021

J of Gastro and Hepatol

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“…[ 14 ] In recent years, combined administration of intestinal peristalsis inhibitors, adsorbents, astringents, intestinal mucosa protectors, and antidepressants in the treatment of IBS have achieved a certain therapeutic effect, but with a long therapeutic course and heavy economic burden for the patient, and with a high recurrence rate after ceasing the drugs. [ 15 ] Therefore, the most urgent and intractable problem for clinical gastroenterologists to deal with is to develop a both effective and economical treatment method that could cope with different symptoms of IBS. [ 16 ]…”

Section: Introductionmentioning

confidence: 99%

Fecal microbiota transplantation for patients with irritable bowel syndrome

Wen

Zhang²,

Shen³

et al. 2018

Medicine

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Irritable bowel syndrome (IBS) is a common functional bowel disease characterized by chronic or recurrent abdominal pain, bloating, constipation, and diarrhea. Many patients with IBS have a poor quality of life due to abdominal discomfort, diarrhea, constipation, and the presence of other diseases. At present, intestinal motility inhibitors, adsorbents, astringents, intestinal mucosal protective agents, and antidepressants have been combined to treat IBS, but the treatment process is long, which results in a large economic burden to patients. Fecal microbiota transplantation (FMT) is a treatment involving the transplantation of functional bacteria from healthy human feces into the gastrointestinal tract of patients; thus, replacing the intestinal flora and modulating intestinal and extra-intestinal diseases. In recent years, the efficacy and economic benefits of FMT in the treatment of IBS have received increasing attention from researchers.A search for randomized controlled trials (RCTs) on treating IBS with FMT will be performed using 9 databases, including PubMed, the Cochrane Library, Embase, ClinicalTrails, China National Knowledge Infrastructure, Sino Med, ScienceDirect, VIP, and Wanfang Data. Two reviewers will independently screen data extraction studies and assess study quality and risk of bias. The risk of bias for each RCT will be assessed against the Cochrane Handbook standards to assess methodological quality. RevMan V.5.3 software will be used to calculate data synthesis when meta-analysis is allowed.This study will provide a high-quality synthesis of existing evidence on the effectiveness and safety of FMT in the treatment of IBS.This study will determine if FMT is an effective and safe intervention for IBS.PROSPERO registration number is PROSPERO CRD42018108080.

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“…Acupuncture relative to Chinese herbal medicine were compared in 4 trials [32, 53–55], 4 other studies assessed the different effects of acupuncture plus Chinese medicine versus Chinese medicine [32, 56–58], acupuncture, acupuncture plus Chinese medicine versus Chinese medicine were examined in 2 studies, 3 studies selected moxibustion as a control [54, 55, 59], 1 study recorded the differential effects of acupuncture, acupuncture plus tuina, and sole tuina treatments [60]. Acupuncture times were 12 at least and 60 at most.…”

Section: Resultsmentioning

confidence: 99%

Comparison between the Effects of Acupuncture Relative to Other Controls on Irritable Bowel Syndrome: A Meta-Analysis

Zheng

Chen

Zhao

et al. 2019

Pain Research and Management

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Background Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder with recurrent abdominal pain and altered defecation habits. We here attempted to determine the effect of acupuncture on IBS. Methods Randomized controlled trials (RCTs) published in CNKI, VIP, Wanfang, PubMed, Cochrane Library, EMBASE, Web of science, and ClinicalTrials.gov till July 17, 2019 were searched. Outcomes were total efficacy rates, overall IBS symptom scores, or global quality of life scores. Standardized mean difference (SMD) with 95% confidence intervals (CI) and risk ratio (RR) with 95% CI were calculated for meta-analysis. Results We included 41 RCTs involving 3440 participants for analysis. 8 RCTs compared acupuncture with sham acupuncture, among which 3 trials confirmed the biological effects of acupuncture, especially in treating abdominal pain, discomfort, and stool frequency. No significant difference was found when acupuncture was compared with sham acupuncture, in terms of effects on IBS symptoms and quality of life (SMD = 0.18, 95% CI −0.26∼0.63, P=0.42; SMD = −0.10, 95% CI −0.31∼0.11, P=0.35), but the pooled efficacy rate data showed a better outcome for true acupuncture (RR = 1.22, 95% CI 1.01∼1.47, P=0.04), which was not supported by sensitivity analysis. Acupuncture was more effective relative to western medicine in alleviating IBS symptoms (RR = 1.17, 95% CI 1.12∼1.23, I2 = 0%, P < 0.00001), whose effect might last 3 months. Besides, acupuncture as an adjunct to western medicine, Chinese medications, or tuina was superior over the single latter treatment (RR = 1.68, 95% CI 1.18 to 2.40, P=0.004; 1.19, 1.03 to 1.36, P=0.02; 1.36, 1.08 to 1.72, P=0.009, respectively), with high heterogeneities. Conclusions Relative to sham controls, acupuncture showed no superiority for treating IBS, while the advantage over western medicine was significant. Acupuncture could be used as an adjunct in clinical settings to improve efficacy. Future high-quality and large-sample-size studies with adequate quantity-effect design need to be conducted.

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Electroacupuncture combined with qibei mixture for diarrhea-predominant irritable bowel syndrome: A randomized controlled trial

Cited by 6 publications

References 11 publications

Acupuncture for functional gastrointestinal disorders: A systematic review and meta‐analysis

Acupuncture for functional gastrointestinal disorders: A systematic review and meta‐analysis

Fecal microbiota transplantation for patients with irritable bowel syndrome

Comparison between the Effects of Acupuncture Relative to Other Controls on Irritable Bowel Syndrome: A Meta-Analysis

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