Electroacupuncture at GV24 and bilateral GB13 improves cognitive ability via influences the levels of Aβ, p-tau (s396) and p-tau (s404) in the hippocampus of Alzheimer’s disease model rats

Yang, Yang; Hu, Shaowen; Lin, Haibo; Jiang, He; Tang, Changyuan

doi:10.1097/wnr.0000000000001518

Cited by 17 publications

(10 citation statements)

References 31 publications

(34 reference statements)

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“…Additionally, many serine phosphorylation sites on the Tau protein were found to be phosphorylated in AD mice, including Ser199, Ser202, Ser396, and Ser404 [ 46 – 48 ]. The mechanism underlying the improvement of cognitive function by EA at GV24 and GB13 may be related to the reduction of Aβ, p-Tau (Ser396), and p-Tau (Ser404) in the hippocampi of AD rats [ 49 ]. Additionally, 2 Hz EA at GV20 and BL23 caused a decrease in hippocampal Aβ and p-Tau (Ser404) [ 50 ].…”

Section: Methodsmentioning

confidence: 99%

The neuroprotective and neural circuit mechanisms of acupoint stimulation for cognitive impairment

et al. 2023

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Cognitive impairment is a prevalent neurological disorder that burdens families and the healthcare system. Current conventional therapies for cognitive impairment, such as cholinesterase inhibitors and N-methyl-d-aspartate receptor antagonists, are unable to completely stop or reverse the progression of the disease. Also, these medicines may cause serious problems with the digestive system, cardiovascular system, and sleep. Clinically, stimulation of acupoints has the potential to ameliorate the common symptoms of a variety of cognitive disorders, such as memory deficit, language dysfunction, executive dysfunction, reduced ability to live independently, etc. There are common acupoint stimulation mechanisms for treating various types of cognitive impairment, but few systematic analyses of the underlying mechanisms in this domain have been performed. This study comprehensively reviewed the basic research from the last 20 years and found that acupoint stimulation can effectively improve the spatial learning and memory of animals. The common mechanism may be that acupoint stimulation protects hippocampal neurons by preventing apoptosis and scavenging toxic proteins. Additionally, acupoint stimulation has antioxidant and anti-inflammatory effects, promoting neural regeneration, regulating synaptic plasticity, and normalizing neural circuits by restoring brain functional activity and connectivity. Acupoint stimulation also inhibits the production of amyloid β-peptide and the phosphorylation of Tau protein, suggesting that it may protect neurons by promoting correct protein folding and regulating the degradation of toxic proteins via the autophagy-lysosomal pathway. However, the benefits of acupoint stimulation still need to be further explored in more high-quality studies in the future.

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Section: Methodsmentioning

confidence: 99%

The neuroprotective and neural circuit mechanisms of acupoint stimulation for cognitive impairment

et al. 2023

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“…The cells would be cultured and levels of Aβ would be measured in cell culture media [12]. Immunofluorescence labeling would be used to detect the protein expression levels of p-tau following the Yang et al methodology [5]. BDNF in frozen rat cortical tissue lysates would also be measured using BDNF ELISA immunoassays [11].…”

Section: Aβ Peptide P-tau and Bdnf Level Measurementmentioning

confidence: 99%

“…These amyloid plaques and NFTs can form within neurons, essentially destroying cell function in the hippocampal region by decreasing the number of neural cells and synapses. [5]. Not only are Aβ peptides and p-tau believed highly associated with cognitive decline, but they are also said to contribute to pathologic changes such as neuroinflammation, loss of hippocampal volume, brain atrophy and neurovascular dysfunction [3].…”

Section: Introductionmentioning

confidence: 99%

Exploring the Relation Between Aerobic Exercise, BDNF and Alzheimer’s Disease: A Research Protocol

Mahmood¹

2022

URNCST Journal

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Introduction: Alzheimer's Disease (AD) is a neurodegenerative disease that impacts the aging population by causing severe cognitive decline. Although there is no cure for AD, studies have shown that lifestyle changes may contribute to preventing AD. The purpose of this study is to investigate how regular exercise can influence a positive change in the cognitive decline that is associated with AD in rats, through a rise in BDNF levels. Methods: The study would be performed through a series of procedures and tests. Rats would be surgically induced with AD and separated into groups exposed to different aerobic exercise regiments. Then, they would either complete a novel object recognition test, to assess behavioural components, or magnetic resonance imaging, to assess structural components. Finally, they would have their brains extracted to measure protein levels. Results: The rats who would have been surgically induced with AD and exposed to regular exercise, are anticipated to have performed better on the novel object recognition test, than the rats surgically induced with AD, but not exposed to regular exercise. The rats who would have been surgically induced with AD and exposed to regular exercise, are anticipated to have shown greater gray matter and hippocampal volume on the magnetic resonance imaging, exhibit greater levels of BDNF, and show decreased levels of Aβ peptides and p-tau during the protein level measurement, than the rats induced with AD but not exposed to regular exercise. Discussion: The study would anticipate finding that the increased release of BDNF that occurs through regular exercise, decreases Aβ peptide and p-tau levels. Through decreasing Aβ peptide and p-tau levels, BDNF can be used as a form of neuroprotection in slowing down the cognitive decline that is associated with AD. Conclusion:The measures applied when researching ways in which the cognitive decline brought on by AD in rats can be reduced, could potentially be translated to further studying therapeutic treatments for AD in humans. These results could lead to similar preventative measures for other neurodegenerative diseases. Future directions may include informing the public of the importance that lifestyle changes may have on neurological health.

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“…Randomized controlled trials (RCTs) suggested that acupuncture could improve cognitive function in patients with mild to moderate cognitive impairment ( 10 , 11 ). In addition, animal experiments are trying to clarify the mechanism of acupuncture ( 12 , 13 ).…”

Section: Introductionmentioning

confidence: 99%

Bibliometric review of 1992–2022 publications on acupuncture for cognitive impairment

Zhou

Lu²,

Xiao³

et al. 2022

Front. Neurol.

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ObjectiveTo explore the development context, research hotspots, and frontiers of acupuncture therapy for cognitive impairment (CI) from 1992 to 2022 by visualization analysis.MethodsArticles about acupuncture therapy for cognitive impairment were retrieved from the Web of Science Core Collection (WoSCC) until 1 March 2022. Basic information was collected by Excel 2007, and VOSviewer 1.6.17 was used to analyze the co-occurrence of countries, institutes, and authors. Co-citation maps of authors and references were analyzed by CiteSpace V.5.8.R3. In addition, CiteSpace was used to analyze keyword clusters and forecast research frontiers.ResultsA total of 279 articles were retrieved, including articles from 19 countries, 334 research institutes, and 101 academic journals. The most published country and institutes were the People's Republic of China (217) and the Fujian University of Traditional Chinese Medicine (40). Ronald C Petersen owned the highest co-citations (56). Keywords and co-cited references cluster showed the main research directions in this area, including “ischemic stroke,” “cerebral ischemia/reperfusion,” “mild cognitive impairment,” “Alzheimer's disease,” “vascular dementia,” “vascular cognitive impairment with no dementia,” “multi-infarct dementia,” “synaptic injury,” “functional MRI,” “glucose metabolism,” “NMDA,” “nuclear factor-kappa b pathway,” “neurotrophic factor,” “matrix metalloproteinase-2 (MMP-2),” “tumor necrosis factor-alpha,” “Bax,” “Caspase-3,” and “Noxa”. Trending keywords may indicate frontier topics, such as “randomized controlled trial,” “rat model,” and “meta-analysis.”ConclusionThis research provides valuable information for the study of acupuncture. Diseases focus on mild cognitive impairment (MCI), Alzheimer's disease (AD), and vascular dementia (VaD). Tauopathies with hyperphosphorylation of Tau protein as the main lesions also need to be paid attention to. The development of functional magnetic resonance imaging (fMRI) will better explain the therapeutic effect of acupuncture treatment. The effect of acupuncture on a single point is more convincing, and acupuncture on Baihui (GV20) may be needed in the future. Finally, the implementation of high-quality multicenter randomized controlled trials (RCTs) requires increased collaboration among experts from multiple fields and countries.

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Electroacupuncture at GV24 and bilateral GB13 improves cognitive ability via influences the levels of Aβ, p-tau (s396) and p-tau (s404) in the hippocampus of Alzheimer’s disease model rats

Abstract: Supplemental Digital Content is available in the text.

Cited by 17 publications

References 31 publications

The neuroprotective and neural circuit mechanisms of acupoint stimulation for cognitive impairment

The neuroprotective and neural circuit mechanisms of acupoint stimulation for cognitive impairment

Exploring the Relation Between Aerobic Exercise, BDNF and Alzheimer’s Disease: A Research Protocol

Bibliometric review of 1992–2022 publications on acupuncture for cognitive impairment

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