Electroacupuncture and moxibustion promote regeneration of injured sciatic nerve through Schwann cell proliferation and nerve growth factor secretion

Hu, Lin-na; Tian, Jin-xin; Gao, Wei; Zhu, Jing; Mou, Fang-fang; Ye, Xiao-chun; Liu, Yu-pu; Lu, Ping-ping; Guo, Hai-dong

doi:10.4103/1673-5374.228731

Cited by 26 publications

(11 citation statements)

References 29 publications

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“…Another research suggested that several miRNAs were involved in chronic electroacupuncture tolerance in the rat hypothalamus ( Cui et al, 2017 ; Zhao X. et al, 2018 ). Our previous studies have confirmed that EA could promote SC migration and NGF expression in injured local nerve as well as BDNF ( Hu et al, 2018 ). In this study, it was first discovered that miR-1b expression was significantly downregulated in the local nerve after EA.…”

Section: Discussionmentioning

confidence: 63%

Electroacupuncture Promoted Nerve Repair After Peripheral Nerve Injury by Regulating miR-1b and Its Target Brain-Derived Neurotrophic Factor

et al. 2020

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Growing evidence indicates that electroacupuncture (EA) has a definite effect on the treatment of peripheral nerve injury (PNI), but its mechanism is not completely clear. MicroRNAs (miRNAs) are involved in the regulation of a variety of biological processes, and EA may enhance PNI repair by regulating miRNAs. In this study, the rat sciatic nerve injury model was treated with EA for 4 weeks. Acupoints Huantiao (GB30) and Zusanli (ST36) were stimulated by EA 20 min once a day, 6 days a week for 4 weeks. We found that EA treatment downregulated the expression of miR-1b in the local injured nerve. In vitro experiments showed that overexpression of miR-1b inhibited the expression of brain-derived neurotrophic factor (BDNF) in rat Schwann cell (SC) line, while BDNF knockdown inhibited the proliferation, migration, and promoted apoptosis of SCs. Subsequently, the rat model of sciatic nerve injury was treated by EA treatment and injection of agomir-1b or antagomir-1b. The nerve conduction velocity ratio (NCV), sciatic functional index (SFI), and S100 immunofluorescence staining were examined and showed that compared with the model group, NCV, SFI, proliferation of SC, and expression of BDNF in the injured nerves of rats treated with EA or EA + anti-miR-1b were elevated, while EA + miR-1b was reduced, indicating that EA promoted sciatic nerve function recovery and SC proliferation through downregulating miR-1b. To summarize, EA may promote the proliferation, migration of SC, and nerve repair after PNI by regulating miR-1b, which targets BDNF.

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Section: Discussionmentioning

confidence: 63%

Electroacupuncture Promoted Nerve Repair After Peripheral Nerve Injury by Regulating miR-1b and Its Target Brain-Derived Neurotrophic Factor

et al. 2020

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“…5 EA has been shown to improve latency and potential amplitude of the peroneal nerve, 6 and both EA and moxibustion can promote nerve regeneration and functional recovery after nerve injury and improve skeletal muscle atrophy. 7 The traditional acupuncture point locations selected in this case are anatomically related to the path of the deep and superficial peroneal nerves (Figure 1(b)), especially ST41, LR3 and ST44. ST41 is at the ankle joint, close to the branch point of the deep peroneal nerve into its medial and lateral branches.…”

Section: Commentmentioning

confidence: 99%

Acupuncture treatment of deep and superficial peroneal nerve injuries caused by V-A ECMO-induced right limb ischemia: a case report

Deng,

Guan,

Liang

et al. 2023

Acupunct Med

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“…Moxibustion stimulates acupoints on the body surface in this way and regulates the functions of Qi, blood, and internal organs through the conduction of meridians throughout the body. After peripheral nerve injury, the use of moxibustion can significantly reduce the degree of muscle atrophy and help restore muscle regeneration [44]. The early use of moxibustion can alleviate muscle atrophy and restore neuronal function.…”

Section: Traditional Chinese Medicine Treatmentmentioning

confidence: 99%

Somatic Nerve Reconstruction and Reinnervation

Yang¹,

Wang²

2020

Somatosensory and Motor Research

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Somatic nerves include somatic sensory and somatic motor, both of which are part of the peripheral nervous system. When somatic motor nerve or somatosensory nerve produces injury, then it belongs to peripheral nerve injury. Peripheral nerve injuries are common disease and complex process in clinical surgery. The severe physical dysfunctions such as motor/sensory loss, dyskinesia, and nutritional disorders in the area innervated caused by the peripheral nerve injury and even leave a lifelong disability. Therefore, somatic nerve reconstruction is essential and remains a major challenge for surgeons. Therapeutic methods include neurorrhaphy and nerve transfer or redistribution reconstruction; traditional Chinese medicineassisted nerve regeneration and repair methods have been increasingly improved, even the functional recovery of peripheral nerve has not made breakthrough progress. All kinds of reconstruction and neural rehabilitation technologies have their own advantages, but they all have some limitations. Although great progress has been made in nerve electrophysiology and microsurgery, the results are still unsatisfactory. This chapter reviews the application of peripheral nerve reconstruction technology and briefly describes the advantages and disadvantages of each method, which will be useful for the selection of clinical treatment.

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Electroacupuncture and moxibustion promote regeneration of injured sciatic nerve through Schwann cell proliferation and nerve growth factor secretion

Cited by 26 publications

References 29 publications

Electroacupuncture Promoted Nerve Repair After Peripheral Nerve Injury by Regulating miR-1b and Its Target Brain-Derived Neurotrophic Factor

Electroacupuncture Promoted Nerve Repair After Peripheral Nerve Injury by Regulating miR-1b and Its Target Brain-Derived Neurotrophic Factor

Acupuncture treatment of deep and superficial peroneal nerve injuries caused by V-A ECMO-induced right limb ischemia: a case report

Somatic Nerve Reconstruction and Reinnervation

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