Electroacupuncture accelerates gastric emptying in association with changes in vagal activity

Ouyang, Hui; Yin, Jieyun; Wang, Zhishun; Pasricha, Pankaj J.; Chen, J. D. Z.

doi:10.1152/ajpgi.00272.2001

Cited by 153 publications

(196 citation statements)

References 29 publications

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“…In our laboratory's previous study, EA at both ST36 and PC6 accelerated gastric emptying of liquid in dogs (30). EA at ST36 stimulated the parasympathetic pathway and accelerated colonic transit in rats (18).…”

Section: Ea Improves Antral Motility Impaired By Rdmentioning

confidence: 74%

“…EA has been applied for the treatment of gastrointestinal disorders (11). Our previous studies showed that EA at ST36 could accelerate gastric empty and restore impaired gastric accommodation in canine models (29,30). The present study was designed to investigate the effects of EA on RD-induced impairment in gastric antral contraction and GSW.…”

Section: Ea Improves Antral Motility Impaired By Rdmentioning

confidence: 99%

“…The location of ST36 is at the proximal one-fifth of the craniolateral surface of the rear leg distal to the head of the tibia in a depression between the muscles of the cranial tibia and the long digital extensor. ST36 is one of the most frequently used acupuncture points for the treatment of gastric diseases and has been used in our previous studies in both humans and dogs (26,30,36). EA at acupoints located on the back [bladder-21 (BL21)] were used for sham acupuncture.…”

Section: Electroacupuncturementioning

confidence: 99%

“…Overall power spectral analysis was applied to the HRV signal and the power in each frequency subband was calculated by a previously validated method (30). It has been well established that the power in the low-frequency band (0.04 -0.15 Hz), LF, represents mainly sympathetic activity, and the power in the high-frequency band (0.15-0.50 Hz), HF, stands purely for parasympathetic or vagal activity (48).…”

Section: Recording and Analysis Of Hrvmentioning

confidence: 99%

“…EA is commonly used in clinical research since it is more reproducible than manual acupuncture, and it has been applied to treat gastrointestinal disorders (11). Our previous studies have shown that EA at ST36 accelerated gastric emptying in both dogs and patients with gastroparesis and restored vagotomy-induced impaired gastric accommodation in dogs (29,30). However, its precise mechanism remains unclear, although the analgesic effect of acupuncture is known to be mediated via the opioid pathway (11).…”

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confidence: 99%

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Electroacupuncture improves impaired gastric motility and slow waves induced by rectal distension in dogs

Chen¹,

Song²,

Yin³

et al. 2008

American Journal of Physiology-Gastrointestinal and Liver Physi

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puncture improves impaired gastric motility and slow waves induced by rectal distension in dogs. Am J Physiol Gastrointest Liver Physiol 295: G614 -G620, 2008. First published July 24, 2008 doi:10.1152/ajpgi.90322.2008 is known to induce upper gastrointestinal (GI) symptoms. The aim of this study was to investigate the effects and underlying mechanisms of RD on gastric slow waves (GSW) and motor activity and furthermore to investigate the effects and mechanisms of electroacupuncture (EA) on GSW and motor activity. Eight female hound dogs chronically implanted with gastric serosal electrodes and a gastric fistula were studied in six separate sessions. Antral motility, GSW, heart rate variability, and rectal pressure were evaluated for the above purposes. 1) RD at a volume of 120 ml suppressed antral motility significantly. Guanethidine blocked the inhibitory effect of RD. EA at ST36 was able to restore the suppressed antral contractions induced by RD (16.6 Ϯ 1.7 vs. 8.0 Ϯ 1.4, P Ͻ 0.001). Naloxone partially blocked the effect of EA on antral contractions. 2) RD reduced the percentage of normal GSW from 98.8 Ϯ 0.8% at baseline to 76.1 Ϯ 8.6% (P Ͻ 0.05) that was increased to 91.8 Ϯ 3.0% with EA. The effects of EA on the GSW were nullified by the presence of naloxone. 3) EA did not show any significant effect on rectal pressure, suggesting that the ameliorating effects of EA on RD-induced impaired gastric motility were not due to a decrease in rectal pressure. 4) EA increased the vagal activity suppressed by RD. In conclusion, RD inhibits postprandial gastric motility and impairs GSW in dogs, and the inhibitory effects are mediated via the adrenergic pathways. EA at ST36 is able to restore the RD-induced impaired GSW and motor activities, possibly by enhancing vagal activity, and is partially mediated via the opioid pathway. EA may have therapeutic potential for functional gastrointestinal disorders. adrenergic pathway; gastric slow waves; naloxone CHRONIC, IDIOPATHIC, slow-transit constipation and constipationdominant irritable bowel syndrome (IBS) are commonly observed in clinical practice. These patients frequently complain of upper abdominal symptoms such as bloating, upper abdominal discomfort or pain, and vomiting. The symptoms overlap with lower abdominal symptoms and are resistant to dietary and pharmacological treatments because of the constipation issues; they are related to the presence of impaired gastrointestinal myoelectrical activity and reduced upper gastrointestinal motor activity (1,4,13,31,33,37). This phenomenon has led to the hypothesis that rectal distension (RD) with fecal stasis in the colorectal region directly causes reflexive inhibition of proximal gastrointestinal motility (5,7,9,22,32,50).A number of investigations have indicated that RD induces upper gastrointestinal symptoms, inhibits gastric tone and accommodation, and delays gastric emptying (3, 14, 20 -21, 24, 34 -35, 50). However, little information about the effects of RD on gastric contractions is available, although gastric co...

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Section: Ea Improves Antral Motility Impaired By Rdmentioning

confidence: 74%