Electroactive polymers for neural interfaces

Large enhancement in neurite outgrowth on a cell membrane-mimicking conducting polymer

“…When Wadhwa et al 47 doped anti-inflammatory drugs and neurotrophic factors into polymer films to enhance the biocompatibility of ECPs, they had limited success, controlling inflammation for only short periods of time. This approach might not be promising for long-term implantation because the drug would eventually be consumed 19,43 .…”

“…Pioneering studies have demonstrated the efficiency of using ECPs for electrical interfacing with neural cells and tissues [18][19][20][21][22][23][24][25][26] .…”

Prospects for Neuroprosthetics: Flexible Microelectrode Arrays with Polymer Conductors

“…For an in-depth discussion see (Merrill et al, 2005;Cogan, 2008;Zhou & Greenberg, 2009;Merrill, 2010). electrochemical or self-assembled monolayer (SAM) formation, it could be shown that brainderived cells attached preferentially to the CP (Cui et al, 2001;Widge et al, 2007;Asplund et al, 2010;Green et al, 2010;Thompson et al, 2010). Recent studies indicate that, apart from its overall geometry and surface chemistry, the nano and micro surface texture of a substrate may have considerable impact on cell adhesion, differentiation, cell morphology and gene expression as well (Wilkinson, 2004;Barr et al, 2010).…”

Zero-Order Release Profiles from A Multistimuli Responsive Electro-Conductive Hydrogel

“…Conductive electroactive polymers (CEPs) [1,2] and hydrogels [3][4][5] are two of the most promising class of materials for biomedical applications The former ones, because its electrically modulated properties, could be engineered for devices like biosensors [6][7][8][9], drug delivery systems [10][11][12] and substrates for neural prostheses [13][14][15][16]. The second ones, due its transport properties, high hydration levels and biocompatibility are extensively found in controlled delivery devices [17], biosensors, contact lenses, catheters, wound dresses and tourniquets [5].…”