Electroactive polyglycine coatings for nanobiosensing applications: Label-free DNA hybridization, DNA-Antitumor agent interaction and antitumor agent determination

Polypyrrole‐Based Nanohybrid Electrodes: Their Preparation and Potential Use for DNA Recognition and Paclitaxel Quantification

“…After interaction between the DNA immobilized electrode and Paclitaxel, decreases in the oxidation peak of G were observed. These responses in the oxidation of this DNA base were attributed to the shielding effect of anticancer drugs for electroactive DNA bases . Peak current of G decreased proportionally with the increasing interaction time.…”

“…It is classified as a plant alkaloid . Anticancer drug interactions with DNA have held an important attention because of pharmaceutical development steps, drug discovery and dose assessment studies like other anticancer drug determination studies . Thus, in the beginning of the interaction study, dsDNA accumulated nanohybrid electrodes were interacted with Paclitaxel for various interaction times (5, 10, 20 and 30 min).…”

“…DNA carries genetic instructions in all known organisms and many viruses that play a critical role for functioning, development and reproduction. Thus, DNA based researches such as DNA detection, DNA differentiation, DNA damage or DNA‐drug interactions have very important place in scientific researches . Nanocomposite based surfaces have provided sensitive, rapid and reliable platforms with amplified modifications and stability.…”

Modified Graphite Surfaces Prepared for Electrochemical Biomolecular Interaction Detection Studies

“…It is well-known that DNA is one of the major target for anticancer drugs due to their ability to interfere with cell growth and division [1][2][3][4][5]. For these reasons, investigation of the interaction between DNA and anticancer drugs is one of the key topics for drug discovery and drug dose determination studies [6][7][8][9]. With this aim in mind, in this paper, investigation of double-stranded DNA (dsDNA) with Mitomycin C (MMC) using electroactive polymer coated electrodes was demonstrated and detailed.…”

“…With this aim in mind, in this paper, investigation of double-stranded DNA (dsDNA) with Mitomycin C (MMC) using electroactive polymer coated electrodes was demonstrated and detailed. MMC is a chemotherapeutic agent known with its antitumour activity and effectively used in gastro-intestinal cancers, anal cancers and breast cancers [7]. There have been various studies based on the investigation of DNA molecule and anticancer drugs.…”