Electroactive composite scaffold with locally expressed osteoinductive factor for synergistic bone repair upon electrical stimulation

Cui, Liguo; Zhang, Jin; Zou, Jun; Yang, Xianrui; Guo, Hui; Tian, Huayu; Zhang, Peibiao; Wang, Yu; Zhang, Ning; Zhuang, Xiuli; Li, Zhong‐Ming; Ding, Jianxun; Chen, Xuesi

doi:10.1016/j.biomaterials.2019.119617

Cited by 165 publications

(98 citation statements)

References 58 publications

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“…The biological performance is the core parameter to evaluate the simulation of cementum microenvironment. The cell adhesion was the critical process orchestrating the subsequent (Han et al, 2019;Cui et al, 2020). The biomimetic cementum exhibited a similar PDLCs attachment with human cementum (Figure 6).…”

Section: Discussionmentioning

confidence: 86%

The Construction of Biomimetic Cementum Through a Combination of Bioskiving and Fluorine-Containing Biomineralization

Hong

et al. 2020

Front. Bioeng. Biotechnol.

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Section: Discussionmentioning

confidence: 86%

The Construction of Biomimetic Cementum Through a Combination of Bioskiving and Fluorine-Containing Biomineralization

Hong

et al. 2020

Front. Bioeng. Biotechnol.

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“…During the healing process, osteo-progenitor cells are recruited and fairly abundant in woven bone. With the osteogenic activity of osteoprogenitor cells, the collagen protein and calcium phosphate are produced, and these basic bone compositions assemble to the complex hierarchy and eventually replace the woven bone, leading to the bone remodeling (Schindeler et al, 2008;Cui et al, 2020). Therefore, the effect of IWBLH on activity of osteo-progenitor cells is pivotal.…”

Section: Discussionmentioning

confidence: 99%

The Injectable Woven Bone-Like Hydrogel to Perform Alveolar Ridge Preservation With Adapted Remodeling Performance After Tooth Extraction

Xie

Liao

et al. 2020

Front. Bioeng. Biotechnol.

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Grafting bone substitute is paramount to prevent the alveolar ridge resorption after tooth extraction and facilitate the subsequent implant treatment. An ideal bone substitute should acquire the excellent osteogenic property, more importantly, possess the suitable remodeling rate in balance with bone formation and desirable clinical manageability. However, none of bone substitute is simultaneously characterized by these features, and currently, the limited remodeling property leads to the excessive waiting time before implantation. Enlightened by woven bone, the transitional tissue that is able to induce osteogenesis during bone healing could be easily remodeled within a short period and depend on the favorable injectability of hydrogel, an injectable woven bone-like hydrogel (IWBLH) was constructed in this study to address the above problems. To mimic the component and hierarchical structure of woven bone, amorphous calcium phosphate (ACP) and mineralized collagen fibril were synthesized and compounded with alginate to form IWBLHs with various ratio. Screened by physiochemical characterization and in vitro biological assays, an optimal IWBLH was selected and further explored in rat model of tooth extraction. Compared with the most widely used bone substitute, we showed that IWBLH could be easily handled to fully fill the tooth socket, perform a comparable function to prevent the alveolar bone resorption, and completely remodeled within 4 weeks. This IWBLH stands as a promising candidate for alveolar ridge preservation (ARP) in future.

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“…Tissue engineering has been used widely (Zhang et al, 2019;Cui et al, 2020;Qiu et al, 2020;Zhu et al, 2020), especially for tissue repair. Also, polymer-based nerve catheters have become the most promising alternatives to autologous transplantation.…”

Section: Nerve Transfermentioning

confidence: 99%

Additive Manufacturing of Nerve Guidance Conduits for Regeneration of Injured Peripheral Nerves

Song

Wang

et al. 2020

Front. Bioeng. Biotechnol.

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As a common and frequent clinical disease, peripheral nerve defect has caused a serious social burden, which is characterized by poor curative effect, long course of treatment and high cost. Nerve autografting is first-line treatment of peripheral nerve injuries (PNIs) but can result in loss of function of the donor site, neuroma formation, and prolonged operative time. Nerve guidance conduit (NGC) serves as the most promising alternative to autologous transplantation, but its production process is complicated and it is difficult to effectively combine growth factors and bioactive substances. In recent years, additive manufacturing of NGCs has effectively solved the above problems due to its simple and efficient manufacturing method, and it can be used as the carrier of bioactive substances. This review examines recent advances in additive manufacture of NGCs for PNIs as well as insight into how these approaches could be improved in future studies.

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Electroactive composite scaffold with locally expressed osteoinductive factor for synergistic bone repair upon electrical stimulation

Cited by 165 publications

References 58 publications

The Construction of Biomimetic Cementum Through a Combination of Bioskiving and Fluorine-Containing Biomineralization

The Construction of Biomimetic Cementum Through a Combination of Bioskiving and Fluorine-Containing Biomineralization

The Injectable Woven Bone-Like Hydrogel to Perform Alveolar Ridge Preservation With Adapted Remodeling Performance After Tooth Extraction

Additive Manufacturing of Nerve Guidance Conduits for Regeneration of Injured Peripheral Nerves

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