Electroactive and antioxidant injectable in-situ forming hydrogels with tunable properties by polyethylenimine and polyaniline for nerve tissue engineering

Karimi‐Soflou, Reza; Nejati, Sara; Karkhaneh, Akbar

doi:10.1016/j.colsurfb.2021.111565

Cited by 32 publications

(11 citation statements)

References 67 publications

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“…The antioxidation activity of polyaniline and its composites has previously been documented in several studies. ,, Also, the current study unambiguously confirmed the antioxidation activity of PANI-CHIT and PANI-PVA samples, which were both capable of scavenging DPPH radicals. Furthermore, the analyses revealed that the samples′ activity differed.…”

Section: Resultsmentioning

confidence: 99%

Enzyme-Catalyzed Polymerization Process: A Novel Approach to the Preparation of Polyaniline Colloidal Dispersions with an Immunomodulatory Effect

et al. 2022

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A green, nature-friendly synthesis of polyaniline colloidal particles based on enzyme-assisted oxidation of aniline with horseradish peroxidase and chitosan or poly(vinyl alcohol) as steric stabilizers was successfully employed. Physicochemical characterization revealed formation of particles containing the polyaniline emeraldine salt and demonstrated only a minor effect of polymer stabilizers on particle morphology. All tested colloidal particles showed in vitro antioxidation activity determined via scavenging of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals. In vitro, they were able to reduce oxidative stress and inhibit the production of reactive oxygen species by neutrophils and inflammatory cytokines by macrophages. The anti-inflammatory effect observed was related to their antioxidant activity, especially in the case of neutrophils. The particles can thus be especially advantageous as active components of biomaterials modulating the early stages of inflammation. In addition to the immunomodulatory effect, the presence of intrinsically conducting polyaniline can impart cell-instructive properties to the particles. The approach to particle synthesis that we employed�an original one using environmentally friendly and biocompatible horseradish peroxidase�represents a smart way of preparing conducting particles with unique properties, which can be further modified by the stabilizers used.

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Section: Resultsmentioning

confidence: 99%

Enzyme-Catalyzed Polymerization Process: A Novel Approach to the Preparation of Polyaniline Colloidal Dispersions with an Immunomodulatory Effect

et al. 2022

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“…Polyaniline components contributed to the robust antioxidative properties, along with an optimal crosslinker concentration of 1.5 wt% PEGS-FA presenting excellent blood clotting capacity, leading to significantly enhanced in vivo wound healing 23 . Similarly, a gelatin-graft-polyaniline/periodate-oxidised alginate hydrogel was reported for potential application of injectable electroconductive and antioxidative hydrogels in neural tissue engineering 101 . Whereas polyaniline provided the antioxidative abilities, the branched polyethyleneimine (PEI) was introduced to tune the properties of hydrogels, and Schiff's base linkages and ionic interactions were applied for the crosslinking of hydrogels 101 .…”

Section: Recent Development Of Injectable Antioxidative Hydrogelsmentioning

confidence: 96%

“…Similarly, a gelatin-graft-polyaniline/periodate-oxidised alginate hydrogel was reported for potential application of injectable electroconductive and antioxidative hydrogels in neural tissue engineering 101 . Whereas polyaniline provided the antioxidative abilities, the branched polyethyleneimine (PEI) was introduced to tune the properties of hydrogels, and Schiff's base linkages and ionic interactions were applied for the crosslinking of hydrogels 101 .…”

Section: Recent Development Of Injectable Antioxidative Hydrogelsmentioning

confidence: 96%

Reactive oxygen species (ROS): utilizing injectable antioxidative hydrogels and ROS-producing therapies to manage the double-edged sword

Newland

et al. 2021

J. Mater. Chem. B

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“…Researchers have developed a gelatin-graft-polyaniline/periodate-oxidized alginate hydrogel using polyethyleneimine with superior properties. The prepared injectable electroconductive hydrogels can also be approached for neural tissue engineering due to their advantageous properties such as cell adhesion and cell proliferation [ 217 ]. A UV irradiation method was adopted to prepare the non-swellable polymeric hydrogels by Ding et al Injectable pentenyl chitosan hydrogels produced via N-acylation reaction was found to be hydrophobic, non-cytotoxic, and with no side effects, which made them favorable as a smart biomaterial and for biological tissue engineering [ 218 ].…”

Section: Potential Applications Of Hydrogel In the Biomedical Sectormentioning

confidence: 99%

Drug Delivery Strategies and Biomedical Significance of Hydrogels: Translational Considerations

et al. 2022

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Hydrogels are a promising and attractive option as polymeric gel networks, which have immensely fascinated researchers across the globe because of their outstanding characteristics such as elevated swellability, the permeability of oxygen at a high rate, good biocompatibility, easy loading, and drug release. Hydrogels have been extensively used for several purposes in the biomedical sector using versatile polymers of synthetic and natural origin. This review focuses on functional polymeric materials for the fabrication of hydrogels, evaluation of different parameters of biocompatibility and stability, and their application as carriers for drugs delivery, tissue engineering and other therapeutic purposes. The outcome of various studies on the use of hydrogels in different segments and how they have been appropriately altered in numerous ways to attain the desired targeted delivery of therapeutic agents is summarized. Patents and clinical trials conducted on hydrogel-based products, along with scale-up translation, are also mentioned in detail. Finally, the potential of the hydrogel in the biomedical sector is discussed, along with its further possibilities for improvement for the development of sophisticated smart hydrogels with pivotal biomedical functions.

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Electroactive and antioxidant injectable in-situ forming hydrogels with tunable properties by polyethylenimine and polyaniline for nerve tissue engineering

Cited by 32 publications

References 67 publications

Enzyme-Catalyzed Polymerization Process: A Novel Approach to the Preparation of Polyaniline Colloidal Dispersions with an Immunomodulatory Effect

Enzyme-Catalyzed Polymerization Process: A Novel Approach to the Preparation of Polyaniline Colloidal Dispersions with an Immunomodulatory Effect

Reactive oxygen species (ROS): utilizing injectable antioxidative hydrogels and ROS-producing therapies to manage the double-edged sword

Drug Delivery Strategies and Biomedical Significance of Hydrogels: Translational Considerations

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