Electro‐oxidation and simultaneous determination of amlodipine and atorvastatin in commercial tablets using carbon nanotube modified electrode

Abstract

Amlodipine besylate and atorvastatin calcium have been determined by the simultaneous voltammetric method at a multi-walled carbon nanotubes:graphite (MWCNTs:G) paste electrode. In comparison with a glassy carbon electrode, the prepared electrode showed an increase in the peak current because of the high electroactive surface area and excellent electronic conductivity of MWCNTs. The dependence of currents and potentials on pH were investigated for these components at the surface of the MWCNTs:G paste electrode. Differential pulse voltammetry was applied as a sensitive technique for simultaneous determination of the drugs in commercial tablets. By anodic differential pulse voltammetry, the calibration plot was linear in the range of 2.5-100 µg/ml with standard deviation between 2.7-7.1 and 1.8-8.3% for amlodipine and atorvastatin, respectively. The detection limit was 1 µg/ml at the prepared electrode in the buffered solution pH 6.

Review Article: Instrumental Analysis of Olopatadine Hydrochloride, Oxeladine Citrate, Amlodipine Besylate and Xipamide

“…Electro-oxidation and simultaneous determination of amlodipine and atorvastatin in commercial tablets using carbon nanotube modified electrode was developed [47]. Amlodipine besylate and atorvastatin calcium have been determined by the simultaneous voltammetric method at a multiwalled carbon nanotubes: Graphite (MWCNTs:G) paste electrode.…”

Electrochemical nanosensors: advances and applications

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Electrodeposited nanoscale zinc oxide particles: facilitating the electron transfer of immobilised protein and biosensing

“…Owing to the notable advantages of NPs such as large surface area, high chemical stability, tunable porosity and biocompatibility, NPs have received vast attention in bioelectrochemical studies. Different kinds of materials and nanomaterials including Co 3 O 4 NPs/multi‐walled carbon nanotubes (MWCNTs)/gelatin [15], cobalt oxide [16, 17], nickel oxide NPs [18], system‐on‐chip devices [19], polymeric 3‐aminophenyl boronic acid monolayer [20], gold (Au)–MWCNT–graphene hybrid composite [21], SiO 2 coated Fe 3 O 4 /MWCNTs [22], CdS nanorods [23], carbon past electrode containing different modifiers [24], Au NPs [25], MWCNTs–Zno composite [26], poly‐3‐hydroxybutyrate membrane [27], lipopolysaccharide films [28] and nanoAu monolayer/sol–gel‐derived carbon ceramic [29] were used in the protein electrochemistry and biosensors. Nanomaterials can act as tiny conduction centres and facilitate the transfer of electrons while maintaining the biocatalytic properties of the proteins.…”