Electro-oxidation and determination of gabapentin at gold electrode

Hegde, Rajesh N.; Swamy, B.E. Kumara; Shetti, Nagaraj P.; Nandibewoor, Sharanappa T.

doi:10.1016/j.jelechem.2009.08.004

Cited by 82 publications

(27 citation statements)

References 34 publications

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“…The anodic peak current produced a linear plot with DA concentration in the range 10nM to 120nM (Inset of Fig. 8) and the linear regression equation is y= 0.0292x+0.205 The limit of detection (LOD) and limit of quantification (LOQ) of DA determination were calculated from the following relations [43].…”

Section: Electrochemical Oxidation Of Da On Modified Electrodementioning

confidence: 99%

Interference‐Free Electrochemical Detection of Nanomolar Dopamine Using Doped Polypyrrole and Silver Nanoparticles

2014

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Abstract:Dopamine (3, 4-dihydroxyphenyl ethylamine, DA) is one of the most important neurotransmitters in the mammalian central nervous system. This paper presents a new approach to detect dopamine using an electrochemical sensor based on a composite made out of chitosan-stabilized silver nanoparticles and p-toluene sulfonic acid-doped ultrathin polypyrrole film, which exploits the synergy between the conducting polymer matrix and silver nanoparticles. These are characterized by TEM, XRD, UV-vis , FTIR, EDAX and the properties of the modified electrode is investigated by electrochemical impedance spectroscopy (EIS). The linear range is from 1x10 -9 M to 1.2x10 serum. Thus modified electrode shows excellent sensitivity, good selectivity and reusability at neutral pH.

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Section: Electrochemical Oxidation Of Da On Modified Electrodementioning

confidence: 99%

Interference‐Free Electrochemical Detection of Nanomolar Dopamine Using Doped Polypyrrole and Silver Nanoparticles

2014

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“…Limited non-derivatization methods were developed for GBP determination in pharmaceutical dosage forms using HPLC with direct UV detection, 20,21) CE with indirect UV detection, 22) cyclic voltammetry, 23) and flow analyses method with chemiluminometric detection. 24) Indirect UV detection using CE was also used for VGB determination in pharmaceutical dosage forms.…”

Section: Pregabalin ((3s)-3-(aminomethyl)-5-methylhexanoic Acid) (Pgbmentioning

confidence: 99%

“…In addition method should meet validation criteria in terms of precision, accuracy, robustness etc., and most of all it has to offer highthroughput. So far developed methods for determination of PGB, 3,5,17,19) GBP, 2,7,8,15,16,18,[20][21][22][23][24] and VGB 2,6,7,18,25) use from a few µL to approximately 1 mL of sample. The sample preparation is the time-consuming step in derivatization methods and in case of PGB, GBP, and VGB derivatization can take from few seconds to 50 min.…”

Section: Pregabalin ((3s)-3-(aminomethyl)-5-methylhexanoic Acid) (Pgbmentioning

confidence: 99%

“…20,21) Inadequate sensitivity can also be problematic in CE with indirect UV detection, moreover between runs rinses of the capillary prolong duration of analysis. 22,25) Cyclic voltammetry 23) and flow analysis with chemiluminometric detection 24) are rarely used for drug determination in pharmaceutical dosage forms and therefore less available for routine quality control analysis. All the above mentioned methods have been partially validated and proved to be suitable for quantification of PGB, GBP, and VGB in pharmaceutical dosage forms, however only a few methods were exposed to robustness test 3,17,[19][20][21][22] which is crucial for routine quality control analysis.…”

Section: Pregabalin ((3s)-3-(aminomethyl)-5-methylhexanoic Acid) (Pgbmentioning

confidence: 99%

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A Simple High-Throughput Method for Determination of Antiepileptic Analogues of γ-Aminobutyric Acid in Pharmaceutical Dosage Forms Using Microplate Fluorescence Reader

Martinc

Vovk

2013

CHEMICAL & PHARMACEUTICAL BULLETIN

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Pregabalin (PGB), gabapentin (GBP), and vigabatrin (VGB) are structural analogues of γ-aminobutyric acid used for the treatment of different forms of epilepsy. Their analytical determination is challenging since these molecules have no significant UV or visible absorption. Several derivatization methods have been developed and used for their determination in bulk or pharmaceutical dosage forms. We aimed to develop a highthroughput method using a microplate reader with fluorescence detection and simple derivatization with fluorescamine. Obtained method involves derivatization step of only 5 min at room temperature and simultaneous measurements of 96 samples (λ ex 395, λ em 476 nm) thus rendering excellent high-throughput analysis. The method was found to be linear with r 2 >0.998 across investigated analytical ranges of 0.75 to 30.0 µg/ mL for PGB, 2.00 to 80.0 µg/mL for GBP, and 1.50 to 60.0 µg/mL for VGB. Intraday and interday precision values did not exceed 4.93%. The accuracy was ranging between 96.6 to 103.5%. The method was also found to be specific since used excipients did not interfere with the method. The robustness study showed that derivatization procedure is more robust than spectrofluorimetric conditions. The developed high-throughput method was successfully applied for determination of drug content and dissolution profiles in pharmaceutical dosage forms of studied antiepileptic drugs.

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“…So far, no traces of any attempts have been found for determination of gabapentin by colorimetric method and the literature is still starving for such analytical procedures. There are number of methods for determination of gabapentin in literature (Manera et al 2009;Lin et al 2004;Jia et al 2012;Ribeiro et al 2007;Abdulrahman & Basavaiah 2011;Abdulrahman & Basavaiah 2012;Jalali et al 2007;Hegde et al 2009;Patel et al 2011;Siddiqui et al 2010).…”

Section: Introductionmentioning

confidence: 99%

Kinetic and Thermodynamic Spectrophotometric Technique to Estimate Gabapentin in Pharmaceutical Formulations using Ninhydrin

et al. 2013

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Background: Simple and sensitive spectrophotometric method is described based on the reaction of drug (gabapentin) with ninhydrin in pure form and in pharmaceutical preparations. Methods: Complex formed during this reaction is measured at 575 nm as a function of time. Kinetic study involve initial-rate, rate-constant and fixed-time (80 minutes) procedures to determine the concentration of the drug.

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Electro-oxidation and determination of gabapentin at gold electrode

Cited by 82 publications

References 34 publications

Interference‐Free Electrochemical Detection of Nanomolar Dopamine Using Doped Polypyrrole and Silver Nanoparticles

Interference‐Free Electrochemical Detection of Nanomolar Dopamine Using Doped Polypyrrole and Silver Nanoparticles

A Simple High-Throughput Method for Determination of Antiepileptic Analogues of γ-Aminobutyric Acid in Pharmaceutical Dosage Forms Using Microplate Fluorescence Reader

Kinetic and Thermodynamic Spectrophotometric Technique to Estimate Gabapentin in Pharmaceutical Formulations using Ninhydrin

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