Electro‐oculography in Albinos

Gahlot, DK; Hansen, Egill

doi:10.1111/j.1755-3768.1974.tb00370.x

Cited by 7 publications

(3 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent studies have suggested that the RPE dysfunction in Best disease results from a disruption in Ca2 + -dependent Cl – channels through intracellular Ca2 + signaling. 31 Interestingly, two studies also recorded EOG in patients with ocular albinism (OA) and oculo-cutaneous albinism (OCA) and found a normal or supra-normal LP/DT ratio with significantly low DT amplitudes, 32 , 33 strikingly similar to the pattern found in patients with NF1, whereas albinism could appear as the clinical opposite of NF1. The authors proposed that these results could be explained by the abnormal melanosomal biogenesis and light-induced retinal damage.…”

Section: Discussionmentioning

confidence: 68%

Function of the Retinal Pigment Epithelium in Patients With Neurofibromatosis Type 1

Touzé

Abitbol

Brémond‐Gignac

et al. 2022

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

Purpose Retinal and choroidal abnormalities in neurofibromatosis type 1 (NF1) remain poorly studied. It has been reported, however, that the function of the retinal pigment epithelium (RPE) in NF1 was abnormal, with a supra-normal Arden ratio of the electro-oculogram (EOG). This study aims to evaluate the function of the RPE, using EOG, first in patients with NF1 compared to controls and second in patients with NF1 with choroidal abnormalities compared to patients with NF1 without choroidal abnormalities. Methods This prospective case-control study included 20 patients with NF1 (10 patients with choroidal abnormalities and 10 patients without) and 10 healthy patients, matched for age. A complete ophthalmologic assessment with multimodal imaging, an EOG, and a full-field electroretinogram were performed for each included patient. The main outcome measured was the EOG light peak (LP)/dark trough (DT) ratio. Results The LP/DT ratio was 3.02 ± 0.52 in patients with NF1 and 2.63 ± 0.31 in controls ( P = 0.02). DT values were significantly lower in patients with NF1 than in controls (240 vs. 325 µV, P = 0.02), while light peak values were not significantly different ( P = 0.26). No difference was found for peak latencies. No significant correlation between the surface and number of choroidal abnormalities and EOG parameters was demonstrated. Conclusions This study confirms the dysfunction of the RPE in patients with NF1, involving a lower DT and a corresponding higher LP/DT ratio. We hypothesize that this pattern may be due to a dysregulation of the melanocytogenesis, inducing a disruption in Ca2 + ion flux and an abnormal polarization of the RPE.

show abstract

Section: Discussionmentioning

confidence: 68%

Function of the Retinal Pigment Epithelium in Patients With Neurofibromatosis Type 1

Touzé

Abitbol

Brémond‐Gignac

et al. 2022

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

show abstract

“…Table V are difficult to interprete. Gahlot &. Hansen (1974) examined the EQG's of normal Caucasians, normal negroes and albinos.…”

Section: Discussionmentioning

confidence: 99%

Normal Values in Clinical Electrooculography

Krogh

1976

Acta Ophthalmologica

View full text Add to dashboard Cite

The following EOG potential and time parameters from 72 normal subjects were analysed: base value B, dark trough D, light peak L, light induced potential rise L-D, interval between beginning of dark adaptation and occurrence of dark through d and interval between dark trough and light peak l. Their relations to sex, age pupillary diameter, degree of iris pigmentation, refractive error, axial length, corneal curvature and diameter, ocular protrusion and interpupillary distance were assessed. Right eye and left eye samples of the EOG parameters were congruent, although individual differences were sometimes appreciable. The levels of B and D were higher in the female half of the sample. A positive correlation existed between age and D level. L-D was negatively correlated to the degree of refractive error and positively correlated to the ocular protrusion. A positive correlation was found between d and the four potential parameters, and there was a positive correlation between age and l. Practical consequences of the statistical analysis relating to the interpretation of such EOG data are discussed.

show abstract

“…Large variability of the results may be a combined effect of various causes difficult to control like the preceding adaptation state of the eyes, ocular protrusion, differences in electrode positions and in resistance of the skin and the periorbital tissues. Also Number of eyes studied Adams 1973Babel et al 1977Gahlot & Hansen 1974Geijer-Mannerfelt & Pallin I968 Hohne 1974Jones et al 1977Kolb 1965Krogh 1977avan Lith & Balik 1970Lobes 1978Markoff et al 1981Pinckers 1979Reeser et al 1970Zonneveldt & van Lith 1980 the common stimulants tobacco and coffee are shown to have effect on EOG (Schmidt 1976). Due to the large scatter in results EOG is considered rather a qualitative than a quantitative test (Krogh 1977b).…”

mentioning

confidence: 97%

Clinical Electro‐oculography

Alanko¹

1984

Acta Ophthalmologica

View full text Add to dashboard Cite

Electro-oculography (EOG), a retinal function test, indirectly records slow, light-induced changes in the potential difference between the anterior and posterior poles of the eye. EOG is a valuable clinical tool in diagnosis of tapetoretinal degenerations, vitelliform foveal dystrophy including the carriers of this disease, retinal intoxications and in differential diagnosis of choroidal malignant melanomas. EOG is not an alternative to electroretinography but yields additional information on the function of the retinal pigment epithelium. The main drawback of the present technique is the high inter-and intraindividual variability of the results.Key words: electro-oculography -corneofundal potential -electrophysiology of the eye -retinal pigment epithelium -retinal intoxications.The basic findings on the electricity of the eye were made over a century ago when the physiologist Emil du Bois-Reymond of Berlin (1849) found a potential difference between the cut optic nerve and the anterior part in the tench fish eye. Later investigations with animals of different species verified du Bois-Reymond's finding and revealed that in vertebrates the anterior part of the eye was positive in relation to the posterior part in contrast to the reverse polarity detected in invertebrates (Kohlrausch 1931). In the literature one can find about ten different synonyms to describe this potential difference across the eye bulb. Through this review the term corneofundal potential is used.Dewar in 1877 measured the corneofundal potential in the human eye and found light-induced changes in the potential. In human beings the cornea is positive and the potential difference betweer, the anterior and posterior poles is several millivolts. Besides changes in illumination also many non-photic stimuli, like ethyl alcohol (Skoog et al. 1975), can induce rhythmic oscillations in the corneofundal potential. A sustained light stimulus induces first an electroretinographic (ERG) response the c-vawe of which is followed by a fast negative transient. Thereafter the potential slowly increases and reaches its maximum in about ten minutes. After the maximum the potential gradually 139

show abstract

Electro‐oculography in Albinos

Cited by 7 publications

References 8 publications

Function of the Retinal Pigment Epithelium in Patients With Neurofibromatosis Type 1

Function of the Retinal Pigment Epithelium in Patients With Neurofibromatosis Type 1

Normal Values in Clinical Electrooculography

Clinical Electro‐oculography

Contact Info

Product

Resources

About