Electro-oculographic routine examination in Parkinson's disease

Cipparrone, L; Ginanneschi, A.; Degl'Innocenti, Francesco; Porzio, Paolo; Pagnini, P; Marini, P.

doi:10.1111/j.1600-0404.1988.tb06966.x

Cited by 22 publications

(16 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Parkinsonian syndrome is an example of how dysfunction of inhibition, which occurs on the level of subcortical structures, can induce saccadic disorders. 1 In a number of studies of patients with Parkinson disease saccadic disorders similar to those described in the present study were observed [16][17][18][19] It should be emphasized that in some cases HIE induced disorders of saccadic electrophysiological parameters were even more pronounced than in Parkinson's patients (in particular three HIE subjects with clearly expressed hypokinetic syndrome). In comparison with Parkinson's patients HIE subjects with hypokinetic syndrome were characterized by increased instability of the latent period of saccades in the coordinated test and a pronounced disturbance of gaze stabilization after termination of saccades that was manifested by tremor eye movement of different amplitudes.…”

Section: Discussionsupporting

confidence: 79%

“…Eye movement, evoked by the location of the LED target along the the horizontal support was recorded from both eyes simultaneously by means of electrooculography (EOG). Recording electrodes were placed at the lateral margins of the eye-pits (orbits) while the referent electrode was attached to the ear [16]. The EOG signal, was amplified and low-pass filtered by a DC amplifier (band pass 0.1 Hz-150 Hz) and subsequently digitized by an A/D converter (512 Hz sampling rate).…”

Section: Neurophysiological Studymentioning

confidence: 99%

“…The fourth level consists of different zones of hemispheric brain cortex: frontal, rear parietal and occipital lobes, prestriar cortex, additional eye movement fields, dorsolateral frontal eye field (Brodmann's area 8) and the posterior cingulate. Disorders in the oculomotor system have been investigated in patients with different syndromes: schizophrenia [10][11][12], attention-deficit/hyperactivity disorder [13][14][15], Parkinson's disease [16][17][18][19], and Alzheimer's disease [20]. However, data on HIE influence of saccadic eye movements are rather scarce.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Saccadic dysfunction in patients with hypoxic-ischemic encephalopathy

2018

J. Integr. Neurosci.

View full text Add to dashboard Cite

Electrophysiological monitoring of saccadic eye movements in patients with hypoxic-ischemic encephalopathy was carried out. Externally guided saccades (prosaccades) were recorded using a patented hardware-software complex for studying a subject's physical activity. Recordings were performed in two independent experimental procedures -for saccades separately and when they were coordinated with movement of the head and hand. In both cases statistically significant differences of latent period and duration of saccadic eye movement were detected for hypoxic-ischemic encephalopathy subjects in comparison with healthy controls of the same age (p < 0.05). Jerking and deviation of eyes after gaze fixation on a target were often present in hypoxicischemic encephalopathy subjects. In some cases saccades of these subjects were asymmetrical among themselves. Hypoxicischemic encephalopathy induced changes in the parameters of autosaccades were also found They were expressed through instability of gaze fixation periods, sometimes asymmetric eye movements, slow gaze shift from one target to another, and disturbance of gaze stabilization (jerking of eyeballs during the saccadic period).

show abstract

Section: Discussionsupporting

confidence: 79%

Section: Neurophysiological Studymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Saccadic dysfunction in patients with hypoxic-ischemic encephalopathy

2018

J. Integr. Neurosci.

View full text Add to dashboard Cite

show abstract

“…Recent electro-oculographic studies on these patients show abnormalities of vestibular and oculomotor systems which are not correlated with clinical features. Deficits in the caloric nystagmus induced in these patients cannot be explained on the basis of an inability to initiate voluntary movement 15. Although a good correlation exists between the extent of oculomotor and peripheral motor dysfunction in Parkinson’s disease,16 many differences exist between the oculomotor and peripheral motor systems in terms of physiology.…”

Section: Discussionmentioning

confidence: 96%

Ocular microtremor in patients with idiopathic Parkinson's disease

Bolger

Bojanić

Sheahan

et al. 1999

Journal of Neurology, Neurosurgery & Psychiatry

View full text Add to dashboard Cite

Abnormalities in the oculomotor control mechanism of patients with idiopathic Parkinson's disease are well recognised. In this study the eVect of Parkinson's disease on tonic output from oculomotor nuclei was studied by using oculomicrotremor as an index of such output. Oculomicrotremor readings were taken from 22 parkinsonian patients and 22 normal healthy volunteers using the piezoelectric strain gauge technique. There was a slower overall tremor frequency, baseline, and burst frequency in the parkinsonian group. There was also a significant increase in the duration of baseline, with a decrease in the number of bursts a second and a decrease in average duration of bursts in the patient group compared with the normal group. One patient, whose medication was withdrawn, showed a marked decrease in mean frequency and baseline frequency with a decrease in number of bursts and increase in baseline duration compared with readings taken when treatment recommenced. These results suggest that variables measured in oculomicrotremor are altered compared with normal subjects, reflecting altered tonic output from oculomotor nuclei in patients with idiopathic Parkinson's disease. (J Neurol Neurosurg Psychiatry 1999;66:528-531)

show abstract

“…Smooth-pursuit ocular movements, which are elicited by asking the subject to track a small target moving smoothly in the line of sight, have been shown to detect even subtle pathological modifications in a wide variety of neurological diseases [2,3,4,8,10,14,15,25,28]. Numerous laboratories are now able to apply routinely a number of visually-controlled eyetracking systems (e.g.…”

Section: Introductionmentioning

confidence: 99%

A new method for analyzing smooth-pursuit eye movements

et al. 1991

View full text Add to dashboard Cite

The study of ocular movements has been increasingly used to detect subtle pathological modifications, caused by a wide variety of neurological diseases. We have developed a new microcomputer-based method for the analysis of smooth-pursuit ocular movements induced by constant velocity targets moving unpredictably at different velocities (including velocity values as high as 100 deg/s). The ocular movements are recorded by an electro-oculographic technique using silver-silver chloride electrodes fixed near the inner and outer canthi of both eyes. The signals are amplified by two DC amplifiers after a low-pass filtering (50 Hz), sampled at 250 Hz and digitized in a 12-bit form by an analog/digital converter. For each patient's evaluation, a series of 20 sweeps of the target is generated. The data analysis, which is performed automatically by the microcomputer, is based on the calculation of four parameters: average peak eye velocity (APEV); typical target velocity (TTV); percent target matching index after saccade removal (PTMI); typical matching target velocity (TMTV) after saccade removal. APEV is calculated as the average of the peak velocities estimated from the 20 sweeps. The purpose of TTV, which is defined as the value of target velocity at which the percent gain has decreased to slightly more than one third of the maximum percent gain, is to provide an overall index of the rate at which the percent gain decreases as the target velocity increases. PTMI describes the eye performance for each value of target velocity.(ABSTRACT TRUNCATED AT 250 WORDS)

show abstract

Electro-oculographic routine examination in Parkinson's disease

Cited by 22 publications

References 15 publications

Saccadic dysfunction in patients with hypoxic-ischemic encephalopathy

Saccadic dysfunction in patients with hypoxic-ischemic encephalopathy

Ocular microtremor in patients with idiopathic Parkinson's disease

A new method for analyzing smooth-pursuit eye movements

Contact Info

Product

Resources

About