Electro-magnetic Templates with Magnetic Nanoparticles for Cell-based Assays

Gertz, Frederick; Khitun, Alexander

doi:10.1016/j.phpro.2016.05.003

Cited by 1 publication

(1 citation statement)

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“…The dead cells were separated individually without disturbing the local environment. Sophisticated, on‐chip integrated microelectromagnet (MEM) systems can be used to manipulate, separate, and trap cells into 2D arrays for high throughput analysis . For instance, Lee et al developed a microeletromagnet matrix to manipulate and sort individual cells .…”

Section: Introductionmentioning

confidence: 99%

Manipulation of Single Cells Using a Ferromagnetic Nanorod Cluster Actuated by Weak AC Magnetic Fields

et al. 2018

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A unique noncontact single cell manipulation technique based on the actuation of magnetic nanorods (MNRs) or clusters (MCs) by nonuniform alternating magnetic fields (nuAMFs) is demonstrated. Compared to the actuation of MNRs/MCs by conventional magnetophoresis, the motion of MNRs/MCs actuated by nuAMFs can be tuned by additional parameters including the shape of MNRs/MCs and the frequency of the applied magnetic fields. The manipulation of a single cell by an actuated MNR/MC are divided into five stages, i.e., approaching, pushing, carrying, dragging, and releasing. The interactions between the MNR/MC and the cell in these stages are investigated in detail both experimentally and numerically. Other applications of cell manipulation, such as concentrating cells at target locations and accumulating MNRs/MCs onto a single cell, are also demonstrated. The single cell manipulation system is simple, low‐cost, and low‐power consumption, and helps advance the state‐of‐the‐art of single‐particle manipulation.

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Section: Introductionmentioning

confidence: 99%