Electro‐kinetically driven route for highly sensitive blood pathology on a paper‐based device

Mani, Naresh Kumar; Das, Sankha Shuvra; Dawn, Sayantan; Chakraborty, Suman

doi:10.1002/elps.201900356

Cited by 29 publications

(14 citation statements)

References 70 publications

(64 reference statements)

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“…Paper‐based diagnostic devices that rely on the movement of reagents and bodily fluids through a fibrous network and often use color changes to signal antigen–antibody reactions in functionalized substrates are of great interest in the purview of affordable healthcare [29,30]. An understanding of the basic physics of molecular transport in paper media is therefore of utilitarian implication.…”

Section: Resultsmentioning

confidence: 99%

Anomalous diffusion in an electrolyte saturated paper matrix

Das

Kumar

Ghosal³

et al. 2020

Electrophoresis

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Anomalous diffusion in an electrolyte saturated paper matrixDiffusion of colored dye on water saturated paper substrates has been traditionally exploited with great skill by renowned water color artists. The same physics finds more recent practical applications in paper-based diagnostic devices deploying chemicals that react with a bodily fluid yielding colorimetric signals for disease detection. During spontaneous imbibition through the tortuous pathways of a porous electrolyte saturated paper matrix, a dye molecule undergoes diffusion in a complex network of pores. The advancing front forms a strongly correlated interface that propagates diffusively but with an enhanced effective diffusivity. We measure this effective diffusivity and show that it is several orders of magnitude greater than the free solution diffusivity and has a significant dependence on the solution pH and salt concentration in the background electrolyte. We attribute this to electrically mediated interfacial interactions between the ionic species in the liquid dye and spontaneous surface charges developed at porous interfaces, and introduce a simple theory to explain this phenomenon.

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Section: Resultsmentioning

confidence: 99%

Anomalous diffusion in an electrolyte saturated paper matrix

Das

Kumar

Ghosal³

et al. 2020

Electrophoresis

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“…Low resolution, poor uniformity Laser cutting 43 Laser cutter None Susceptible to contamination Cutting 44,45 Scissors, cutter None Dimensional accuracy is poor Wax printing is one of the most widely used techniques for easy manufacturing of paper-based devices. The key challenge associated with this technique is that the wax diffuses in three possible directions in an equivalent manner; while vertical diffusion of molten wax is the only intended direction.…”

Section: Commercial Water Repellentmentioning

confidence: 99%

Microfluidics on Porous Substrates Mediated by Capillarity-Driven Transport

Kar

Das

Laha

et al. 2020

Ind. Eng. Chem. Res.

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Microfluidic systems on porous substrates, including paper-based analytical platforms, have attracted significant attention in recent times, primarily attributed to their diversified applications ranging from bio-analytical devices for healthcare technologies to green energy generation and flexible electronics. In this short review, we attempt to provide a concise overview about the fundamental premises of functionalities of these devices, starting from the understanding of flow in single one-dimensional conduit. This can be extended to more complex systems, where an intrinsic capillary action offers the necessary provisions for continuous maintenance of heterogeneous flow over multiple spatio-temporal scales, which essentially facilitates the needs of specific applications. We discuss about few specific applications as demonstrative examples which are solely triggered by the intrinsic capillary action of the porous media. These specific examples delineate the fact that flexible architecture of the devices in combination with the inherent capillary driven phenomena makes it suitable to meet the desired user-specific demands at affordable costs, rendering them immensely suitable for the low resource settings environment.

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“…A requirement of minimal volume for diagnosis as well as detection of biosamples/biofluids has drawn a great deal of research interest of microfluidics in biomedical, biological, and biochemical applications [1][2][3][4][5][6][7][8]. Proper mixing of biofluids and biosamples at a higher flow rate is essential for their effective diagnosis and quick prediction in biochemistry analysis of the aforementioned applications [9][10].…”

Section: Introductionmentioning

confidence: 99%

Numerical study of the vortex‐induced electroosmotic mixing of non‐Newtonian biofluids in a nonuniformly charged wavy microchannel: Effect of finite ion size

2021

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We propose a micromixer for obtaining better efficiency of vortex induced electroosmotic mixing of non-Newtonian bio-fluids at a relatively higher flow rate, which finds relevance in many biomedical and biological applications. To represent the rheology of non-Newtonian fluid, we consider the Carreau model in this study, while the applied electric field drives the constituent components in the micromixer. We show that the spatial variation of the applied field, triggered by the topological change of the bounding surfaces, upon interacting with the non-uniform surface potential gives rise to efficient mixing as realized by the formation of vortices in the proposed micromixer. Also, we show that the phase-lag between surface potential leads to the formation of asymmetric vortices. This behavior offers better mixing performance following the appearance of undulation on the flow pattern. Finally, we establish that the assumption of a point charge in the paradigm of electroosmotic mixing, which is not realistic as well, under-predicts the mixing efficiency at higher amplitude of the non-uniform zeta potential. The inferences of the present analysis may guide as a design tool for micromixer where rheological properties of the fluid and flow actuation parameters can be simultaneously tuned to obtain phenomenal enhancement in mixing efficiency.

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Electro‐kinetically driven route for highly sensitive blood pathology on a paper‐based device

Cited by 29 publications

References 70 publications

Anomalous diffusion in an electrolyte saturated paper matrix

Anomalous diffusion in an electrolyte saturated paper matrix

Microfluidics on Porous Substrates Mediated by Capillarity-Driven Transport

Numerical study of the vortex‐induced electroosmotic mixing of non‐Newtonian biofluids in a nonuniformly charged wavy microchannel: Effect of finite ion size

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