Electro-Acupuncture at GV.4 Improves Functional Recovery in paralyzed rats after a Traumatic Spinal Cord Injury

O, Juarez Becerril; H, Salgado Ceballos; C, Anguiano Solis; B, Alvarado Sanchez; Me, Lopez Hernandez; A, Diaz Ruiz; S, Torres Castillo

doi:10.3727/036012916x14533115160688

Cited by 7 publications

(4 citation statements)

References 45 publications

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“…Macroscopically, the normal physiological function of the diseased muscle is affected, resulting in muscle tension. In the process of exerting its function, it is superior to the overall role of the muscle system and the support of biological forces, which will destroy the original balance of the skeletal system, aggravate the degeneration of the cervical vertebral body, and form a vicious circle [16].…”

Section: Etiology and Clinical Manifestations Of Cervicalmentioning

confidence: 99%

[Retracted] Study on the Prescription of Acupuncture in the Treatment of Cervical Spondylotic Radiculopathy Based on Computer Vision Image Analysis

Xiong

Wang

2022

Contrast Media & Molecular Imaging

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Cervical spondylosis (CS) is a common clinical orthopedic disease. Among cervical spondyloses, cervical spondylotic radiculopathy (CSR) is the most common. Its clinical manifestations are localized neck pain and radial numbness of the shoulder, upper arm, forearm, and even fingers. As far as the status quo is concerned, with the change of lifestyle and working style, the popularity of computer and other entertainment devices, people’s neck flexion time has increased significantly compared with the past, the incidence rate of CSR has also increased year by year, and the group of onset has become younger and younger. According to the symptoms, CSR in Chinese medicine belongs to the category of “arthralgia syndrome” and “bone arthralgia.” Western medicine has many side effects in the treatment of CSR, while surgical treatment is painful and expensive. Most patients are not willing to accept it. Traditional Chinese medicine acupuncture can relieve the pain, numbness, and other discomforts of CSR, and the acupuncture treatment has less trauma and is a simple operation. At present, there are few acupoint prescriptions for acupuncture in the treatment of CSR. Therefore, the analysis of acupuncture point selection based on computer vision image has important practical significance for the scientific and progressive exploration of CSR acupuncture treatment. In this paper, the etiology, pathology, and clinical manifestations of radical treatment of CS are deeply studied by using literature data and mathematical statistics. The prescription research experiment of acupuncture in the treatment of CSR based on computer was established, and the treatment method was studied by observing VAS, NPQ, and other indexes. The total effective rate was 95.13% in the experimental group and 85.72% in the control group. It is hoped that the research direction of this paper can provide reference for the diversified development of acupuncture and moxibustion and for the treatment ideas and methods of cervical spondylotic radiculopathy.

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Section: Etiology and Clinical Manifestations Of Cervicalmentioning

confidence: 99%

[Retracted] Study on the Prescription of Acupuncture in the Treatment of Cervical Spondylotic Radiculopathy Based on Computer Vision Image Analysis

Xiong

Wang

2022

Contrast Media & Molecular Imaging

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“…The results from a traumatic SCI model study showed that electroacupuncture at GV26 reduces radical hydroxyl concentration and increases lipid peroxidation. At the same time, stimulation of GV4 decreases oxidative stress and improves motor function recovery in the hind limbs of rats with paralysis, indicating electroacupuncture at GV4 could be a therapeutic alternative ( Juarez Becerril et al, 2015 ). Jiang et al found that electroacupuncture at Shuigou (DU26) and Fengfu (DU16) acupoints induce antioxidation effects by enhancing the SOD activity and decreasing the MDA level ( Jiang et al, 2014 ).…”

Section: Mechanism Of Acupuncture Therapy In Spinal Cord Injurymentioning

confidence: 99%

Mechanism Underlying Acupuncture Therapy in Spinal Cord Injury: A Narrative Overview of Preclinical Studies

Jiang¹,

Sun²,

Chen³

2022

Front. Pharmacol.

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Spinal cord injury (SCI) results from various pathogenic factors that destroy the normal structure and function of the spinal cord, subsequently causing sensory, motor, and autonomic nerve dysfunction. SCI is one of the most common causes of disability and death globally. It leads to severe physical and mental injury to patients and causes a substantial economic burden on families and the society. The pathological changes and underlying mechanisms within SCI involve oxidative stress, apoptosis, inflammation, etc. As a traditional therapy, acupuncture has a positive effect promoting the recovery of SCI. Acupuncture-induced neuroprotection includes several mechanisms such as reducing oxidative stress, inhibiting the inflammatory response and neuronal apoptosis, alleviating glial scar formation, promoting neural stem cell differentiation, and improving microcirculation within the injured area. Therefore, the recent studies exploring the mechanism of acupuncture therapy in SCI will help provide a theoretical basis for applying acupuncture and seeking a better treatment target and acupuncture approach for SCI patients.

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“…The SEP incubation period of combination group was significantly lower than that of Jiaji EA group and ganglioside group (P < 0.05), indicating that Jiaji EA group and ganglioside ester treatment can better promote the regeneration and repair of injured nerves. Previous studies have shown that Jiaji EA has certain therapeutic effect on SCI in rats ( Sun, 1996 , Xu et al, 2006 , Juarez Becerril et al, 2015 )and ganglioside can promote the recovery of neurological function after SCI ( Constantini and Young, 1994 , Geisler et al, 1993 , Constantini and Young, 1994 , Donaldson et al, 2000 ). Our results further suggested that the combination of Jiaji EA and ganglioside ester effectively promoted the recovery of spinal cord nerve function in spinal cord rats.…”

Section: Discussionmentioning

confidence: 98%

Effect of ganglioside combined with Chip Jiaji electro-acupuncture on Nogo-NgR signal pathway in SCI rats

Wang²,

Liu

2021

Saudi Journal of Biological Sciences

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At present, the effect of ganglioside combined with Jiaji electroacupuncture (Jiaji EA) on SCI still remains unclear. This study explores the effect of ganglioside combined with electroacupuncture on Nogo/NgR signal pathway in spinal cord tissue of spinal cord injury (SCI) rats. Basso Beattie Bresnahan (BBB) score was used to evaluate spinal cord function after modeling and 14 days post ganglioside and electroacupuncture treatment. RT-qPCR and western blot were performed to evaluate the expression levels of targets in spinal cord tissue. After 14 days of treatment, the BBB scores of Jiaji EA group, ganglioside group and combination group were all improved. The expression levels of IL-1β, IL-6 and TNF-α in Jiaji EA group, ganglioside group and combination group were significantly lower than those in model group. Both of mRNA and protein expression levels of Nogo-A, NgR and LINGO-1 in the model group were significantly higher than those in the Jiaji EA group, ganglioside group and combination group. Ganglioside combined with Jiaji EA has a stronger effect on promoting the recovery of nerve function. Its mechanism of action may be related to its inhibition of the expression of proinflammatory cytokines such as IL-1β, IL-6 and TNF-α and Nogo-NgR signal pathway to promote neuronal growth. Our results will provide fundamental information for further SCI studies.

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Electro-Acupuncture at GV.4 Improves Functional Recovery in paralyzed rats after a Traumatic Spinal Cord Injury

Cited by 7 publications

References 45 publications

[Retracted] Study on the Prescription of Acupuncture in the Treatment of Cervical Spondylotic Radiculopathy Based on Computer Vision Image Analysis

[Retracted] Study on the Prescription of Acupuncture in the Treatment of Cervical Spondylotic Radiculopathy Based on Computer Vision Image Analysis

Mechanism Underlying Acupuncture Therapy in Spinal Cord Injury: A Narrative Overview of Preclinical Studies

Effect of ganglioside combined with Chip Jiaji electro-acupuncture on Nogo-NgR signal pathway in SCI rats

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