Electro-Acupuncture Alleviates Cisplatin-Induced Anorexia in Rats by Modulating Ghrelin and Monoamine Neurotransmitters

Baek, Ji Yun; Trinh, Tuy An; Huh, Wonsang; Song, Ji Hoon; Kim, Ho; Lim, Juhee; Kim, Jinhee; Choi, Hyun Jin; Kang, Ki Sung

doi:10.3390/biom9100624

Cited by 13 publications

(16 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Electroacupuncture at Neiguan (PC 6) and Jianshi (PC 5) could reduce nausea and vomiting during chemotherapy, which was possibly associated with the deduction of 5-HT 3 and dopamine [26]. It was also confirmed that electro-acupuncture(EA) at Zhongwan (CV12) alleviated the cisplatin-induced anorexia in rats by reducing the levels of plasma monoamine neurotransmitters 5-hydroxytryptamine, 5-hydroxyindoleacetic acid, dopamine, and norepinephrine; as well as upregulating the expression of ghrelin and neuropeptide Y [27]. In another rat model, EA at CV12 not only attenuated the cisplatin-induced increase in 5-HT but also suppressed neuronal activation marker c-Fos expression in the nucleus tractus solitarius (NTS) [28].…”

Section: Discussionmentioning

confidence: 77%

Efficacy of acupuncture in the prevention and treatment of chemotherapy-induced nausea and vomiting in patients with advanced cancer: a multi-center, single-blind, randomized, sham-controlled clinical research

Wang

et al. 2020

Chin Med

View full text Add to dashboard Cite

Background: Chemotherapy-induced nausea and vomiting (CINV) is a common and distressing side effect. We conducted this clinical trial to compare the effectiveness of true acupuncture vs. sham acupuncture in controlling chemotherapy-induced nausea and vomiting (CINV) among patients with advanced cancer. Methods: A total of 134 participants were randomly allocated into true acupuncture (TA) (n = 68) and sham acupuncture (SA) (n = 66) groups. Participants in both groups received acupuncture session twice on the first day of chemotherapy, and once consecutively on the following 4 days. The primary outcome was using the Common Terminology Criteria for Adverse Events (CTCAE) to assess CINV. The secondary outcome measures were the Eastern Cooperative Oncology Group score (ECOG), Simplified Nutritional Appetite Questionnaire (SNAQ), and Hospital Anxiety and Depression scale (HADS). Results: Compared to the SA group, the TA group didn't show significant improvement in complete response rates of chemotherapy-induced nausea and vomiting (all P > 0.05). However, the TA group could modestly reduce the severity of nausea (from day-3 to day-21, P < 0.05) or vomiting (from day-4 to day-21, P < 0.05), which is notably superior to the control group. Besides, TA promoted the nutritional status of patients with a significantly higher score comparing to the SA group on day 14 (21.82 vs.20.12, P = 0.003) and day 21 (22.39 vs. 20.43, P = 0.001). No apparent differences were found in anxiety and depression assessment between these groups. Participants in both groups were well tolerant of acupuncture therapy. There was no adverse event occurs in our study. Conclusion: Acupuncture as an adjunctive approach could alleviate the severity of chemotherapy-induced nausea and vomiting compared to the sham control, even though the effect of acupuncture in preventing CINV occurring is relatively modest.

show abstract

Section: Discussionmentioning

confidence: 77%

Efficacy of acupuncture in the prevention and treatment of chemotherapy-induced nausea and vomiting in patients with advanced cancer: a multi-center, single-blind, randomized, sham-controlled clinical research

Wang

et al. 2020

Chin Med

View full text Add to dashboard Cite

show abstract

“…For intracerebral hemorrhagic rats with increased release of CA, acupuncture at PC-6, GV-26 and ST-9 can inhibit the release of CA [ 49 ]. Studies have proven that electroacupuncture can reduce the levels of the plasma monoamine neurotransmitters 5-HT, DA and NE to relieve anorexia in rats [ 50 ]. As narrated above, the effects of acupuncture on various diseases are related to the regulation of monoamine neurotransmitters.…”

Section: Mechanisms Of Acupuncture On the Neuro-endocrine-immune Networkmentioning

confidence: 99%

Research Progress on the Mechanism of the Acupuncture Regulating Neuro-Endocrine-Immune Network System

Cui

Song

Jin

et al. 2021

Veterinary Sciences

View full text Add to dashboard Cite

As one of the conventional treatment methods, acupuncture is an indispensable component of Traditional Chinese Medicine. Currently, acupuncture has been partly accepted throughout the world, but the mechanism of acupuncture is still unclear. Since the theory of the neuro-endocrine-immune network was put forward, new insights have been brought into the understanding of the mechanism of acupuncture. Studies have proven that acupuncture is a mechanical stimulus that can activate local cell functions and neuroreceptors. It also regulates the release of related biomolecules (peptide hormones, lipid hormones, neuromodulators and neurotransmitters, and other small and large biomolecules) in the microenvironment, where they can affect each other and further activate the neuroendocrine-immune network to achieve holistic regulation. Recently, growing efforts have been made in the research on the mechanism of acupuncture. Some researchers have transitioned from studying the mechanism of acupuncture as a single linear pathway to using systems approaches, including metabolomics, genomics, proteomics and biological pathway analysis. This review summarizes the research progress on the neuro-endocrine-immune network related mechanism of acupuncture and discusses its current challenges and future directions.

show abstract

“…Acupuncture and EA have been shown to improve insomnia by reducing the sympathetic nervous activity 73 , suppressing the activation of the hypothalamic-pituitary-adrenal (HPA) axis 74 , 75 , increasing the levels of Gamma-aminobutyric acid (GABA) and GABA(A) receptor 76 , and elevating the generation and secretion of melatonin 77 . EA at CV12 has been shown to improve CADS via an increase in the secretion of ghrelin and cholecystokinin (CCK) and a decrease in the secretion of 5-hydroxytryptamine (5-HT) into the serum 9 , 78 . In addition, chronic EA at ST36 has been shown to improve cisplatin-induced dyspepsia via modulating the production of the vagal and gastrointestinal hormones including fasting ghrelin, glucagon-like peptide-1, and peptide YY 37 .…”

Section: Mechanisms Related To the Therapeutic Effects Of Acupuncture And Eamentioning

confidence: 99%

The Therapeutic Effects of Acupuncture and Electroacupuncture on Cancer-related Symptoms and Side-Effects

Han¹,

Fu²,

Le³

et al. 2021

J. Cancer

View full text Add to dashboard Cite

In addition to cancer-related death, malignant progression also leads to a series of symptoms and side-effects, which would detrimentally affect cancer patients' the quality of life, adversely influence their adherence to treatments, and, therefore, negatively affect their long-term survival. Acupuncture and electroacupuncture (EA), as two classic treatment methods in traditional Chinese medicine, have been widely employed to cure various diseases. Recently, the clinical application of acupuncture and EA in cancer patients has received great attention. In this review, we summarized the clinical application of acupuncture and EA in alleviating the cancer symptoms, reducing the cancer treatment-related side-effects, and relieving the cancer pain. The symptoms and side-effects discussed in this review include fatigue, insomnia, chemotherapy-associated dyspepsia syndrome (CADS), pain, xerostomia, and anxiety and depression. The underlying mechanisms of the therapeutic effects of acupuncture and EA might be related to the regulation of the mitochondrial function, coordination of the activity of the nervous system, adjustment of the production of neurotransmitters, and alleviation of the immune responses. In conclusion, acupuncture and EA have been proved to be beneficial for cancer patients. More research, however, is required to clarify the potential mechanisms behind acupuncture and EA for widespread adoption in clinical application.

show abstract

Electro-Acupuncture Alleviates Cisplatin-Induced Anorexia in Rats by Modulating Ghrelin and Monoamine Neurotransmitters

Cited by 13 publications

References 34 publications

Efficacy of acupuncture in the prevention and treatment of chemotherapy-induced nausea and vomiting in patients with advanced cancer: a multi-center, single-blind, randomized, sham-controlled clinical research

Efficacy of acupuncture in the prevention and treatment of chemotherapy-induced nausea and vomiting in patients with advanced cancer: a multi-center, single-blind, randomized, sham-controlled clinical research

Research Progress on the Mechanism of the Acupuncture Regulating Neuro-Endocrine-Immune Network System

The Therapeutic Effects of Acupuncture and Electroacupuncture on Cancer-related Symptoms and Side-Effects

Contact Info

Product

Resources

About