Electricity‐Wettability Controlled Fast Transmission of Dopamine in Nanochannels

Abstract

Achieving fast transmembrane transmission of molecules in organisms is a challenging problem. Inspired by the transport of Dopmine (DA) in organisms, the DA transporter (DAT) binds to DA in a way that has a ring recognition (the recognition group is the tryptophan group). Herein, D‐Tryptophan‐pillar[5]arene (D‐Trp‐P5) functionalized conical nanochannel is constructed to achieve fast transmission of DA. The D‐Trp‐P5 functionalized nanochannel enables specific wettability recognition of DA molecules and has great cycle stability. With the controlling of voltage to wettability, the transport flux of DA is up to 499.73 nmol cm−2 h−1 at −6 V, 16.88 times higher than that under positive voltages. In response to these results, a high‐throughput DA transport device based on controlled electricity‐wettability is provided.

Advances in nanofluidic field-effect transistors: external voltage-controlled solid-state nanochannels for stimulus-responsive ion transport and beyond

“…Similar behaviors have been reported in other systems. [68][69][70][71][72] Fig. 3 Scheme illustrating the implications of the variations in the (a) free volume and (b) surface wettability of the channel over the I-V curves.…”

A Visible‐Light Regulated ATP Transport in Retinal‐Modified Pillar[6]arene Layer‐by‐Layer Self‐Assembled Sub‐Nanochannel

“…The experimental results showed that it is beneficial to transport negatively charged ATP in the ReÀ P6 channel, and the transport flux gradually increases with the increasing of applied positive voltage. [50][51][52][53][54] Among them, the mercapto ethylamine pillar [6]arene has a robust selective interaction with ATP, facilitating ATP to enter the ReÀ P6-channel. Meanwhile, the departure of ATP in the sub-nanochannel also requires an additional driving force to promote ATP to leave the membrane of the ReÀ P6-channel.…”