“…One mechanism for hearing loss is disruption of the vascular barrier in the stria vascularis (Cadoni et al, 2002; Fattori et al, 2001; Naarendorp et al, 1998; Ottaviani et al, 1999), with subsequent loss of endocochlear potential (Lin et al, 1997; Ruckenstein et al, 1999). Study of the vascular system in the inner ear has a long and rich history, which has been well-documented in previous reviews (Axelsson, 1988; Axelsson et al, 1986; Kimura, 1986; Lawrence, 1980; Miller et al, 1988; Miller et al, 1995a; Nakashima et al, 2003; Nuttall, 1988; Seidman et al, 1999b; Sillman et al, 1989; Wangemann, 2002a). Animal models of cochlear microcirculation have provided a good understanding of cell-mediated CoBF homeostasis, and further studies will extend this basic understanding to clinical studies, which directly address vascular-related hearing disorders.…”