Electrically Evoked Responses in Onset Chopper Neurons in Guinea Pig Cochlear Nucleus

Mulders, Wilhelmina; Harvey, Alan R.; Robertson, Donald

doi:10.1152/jn.01148.2006

Cited by 18 publications

(22 citation statements)

References 41 publications

(53 reference statements)

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“…It may be possible that the leftward shift is brought about by activation of MOC collaterals. Electron microscopical data suggest an excitatory action of MOC collaterals in the cochlear nucleus on both large and varicose dendrites (Winter et al, 1989;Benson and Potashner, 1990;Benson and Brown, 1990;Brown, 1993;Benson et al, 1996;Horvath et al, 2000) and previously we have obtained physiological evidence in support of a direct excitatory action of MOC collaterals on CN neurons (Mulders et al, 2002(Mulders et al, , 2003(Mulders et al, , 2007. This is in conflict with results of Seluakumaran et al (2008) who found that all effects of MOC stimulation on CNIC I/O functions in quiet were eliminated by gentamicin block of peripheral MOC action, suggesting that the MOC collaterals do not have an effect under these conditions.…”

Section: Effects Of Moc Activation On Masked Responsessupporting

confidence: 64%

Unmasking effects of olivocochlear efferent activation on responses of inferior colliculus neurons

2008

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Section: Effects Of Moc Activation On Masked Responsessupporting

confidence: 64%

Unmasking effects of olivocochlear efferent activation on responses of inferior colliculus neurons

2008

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“…Medial OC neurons are known to have collaterals projecting to the CN (Winter et al, 1989;Benson and Brown, 1990;Benson and Potashner, 1990;Brown, 1993;Benson et al, 1996;Horváth et al, 2000), and we have previously shown direct excitatory effects of these collaterals on CN neurons, in particular onset chopper neurons (Mulders et al, 2002(Mulders et al, , 2003(Mulders et al, , 2007). These neurons are thought to provide wide band inhibition to other CN neurons (Verhey et al, 2003;Arnott et al, 2004;Neuert et al, 2004) and could be responsible for the modulation of spontaneous activity remaining after cochlear strychnine.…”

Section: Discussionmentioning

confidence: 49%

Efferent Pathways Modulate Hyperactivity in Inferior Colliculus

Mulders

Seluakumaran²,

Robertson³

2010

Journal of Neuroscience

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Animal models have demonstrated that mild hearing loss caused by acoustic trauma results in spontaneous hyperactivity in the central auditory pathways. This hyperactivity has been hypothesized to be involved in the generation of tinnitus, a phantom auditory sensation. We have recently shown that such hyperactivity, recorded in the inferior colliculus, is still dependent on cochlear neural output for some time after recovery (up to 6 weeks). We have now studied the capacity of an intrinsic efferent system, i.e., the olivocochlear system, to alter hyperactivity. This system is known to modulate cochlear neural output. Anesthetized guinea pigs were exposed to a loud sound and after 2 or 3 weeks of recovery, single-neuron recordings in inferior colliculus were made to confirm hyperactivity. Olivocochlear axons were electrically stimulated and effects on cochlear neural output and on highly spontaneous neurons in inferior colliculus were assessed. Olivocochlear stimulation suppressed spontaneous hyperactivity in the inferior colliculus. This result is in agreement with our earlier finding that hyperactivity can be modulated by altering cochlear neural output. Interestingly, the central suppression was generally much larger and longer lasting than reported previously for primary afferents. Blockade of the intracochlear effects of olivocochlear system activation eliminated some but not all of the effects observed on spontaneous activity, suggesting also a central component to the effects of stimulation. More research is needed to investigate whether these central effects of olivocochlear efferent stimulation are due to central intrinsic circuitry or to coactivation of central efferent collaterals to the cochlear nucleus.

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“…Oc neurons still showed at least two distinct early peaks in their PSTHs (Fig. 2 D), very wide dynamic range and higher firing rates to noise than to pure tone stimuli (Winter and Palmer, 1995;Arnott et al, 2004;Mulders et al, 2007). Chopper-type and primary-like categories were easily distinguishable in these animals regardless of spontaneous firing rate (Fig.…”

Section: Methodsmentioning

confidence: 86%

Hyperactivity in the Ventral Cochlear Nucleus after Cochlear Trauma

Vogler¹,

Robertson²,

Mulders³

2011

J. Neurosci.

121

100

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The emergence of hyperactivity in the form of elevated spontaneous firing rates after cochlear trauma has been well documented in a number of central auditory structures, including the auditory cortex, inferior colliculus, and dorsal subdivision of the cochlear nucleus. This hyperactivity is of interest as a possible neural substrate of tinnitus. Whether the ventral subdivision of the cochlear nucleus shows hyperactivity has never been investigated despite the fact that, like the dorsal division, it also receives direct input from the damaged cochlea and supplies major ascending inputs to brainstem and midbrain auditory centers. We investigated spontaneous neuronal firing rates in the ventral cochlear nucleus in a guinea pig model of cochlear trauma in which we have shown that hyperactivity consistently develops in the inferior colliculus (Mulders and Robertson, 2009). The mean spontaneous firing rates of ventral cochlear nucleus neurons was significantly elevated compared to sham controls. This hyperactivity was more evident in primary-like and onset categories of neurons. Hyperactivity in the ventral subdivision of cochlear nucleus therefore needs to be considered in relation to neural models of the genesis of tinnitus.

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Electrically Evoked Responses in Onset Chopper Neurons in Guinea Pig Cochlear Nucleus

Cited by 18 publications

References 41 publications

Unmasking effects of olivocochlear efferent activation on responses of inferior colliculus neurons

Unmasking effects of olivocochlear efferent activation on responses of inferior colliculus neurons

Efferent Pathways Modulate Hyperactivity in Inferior Colliculus

Hyperactivity in the Ventral Cochlear Nucleus after Cochlear Trauma

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