Electrically Evoked Compound Action Potential (ECAP) of the Cochlear Nerve in Response to Pulsatile Electrical Stimulation of the Cochlea in the Rat: Effects of Stimulation at High Rates

Haenggeli, Andre; Js, Zhang; Mw, Vischer; Pelizzone, M.; Rouiller, Eric M.

doi:10.3109/00206099809072989

Cited by 39 publications

(45 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the absence of hair cells, the auditory nerve is normally silent, but when hair cells are present, there is spontaneous activity, which can affect the responses of the nerve to electrical stimulation (Wilson 1997;Haenggeli et al 1998;Hu et al 2003;Miller et al 2006). In our study, the presence or absence of spontaneous activity in the auditory nerve was assessed by recording ensemble activity (Dolan et al 1990;Searchfield et al 2004) from the cochlear implant electrodes in all group I animals and in four group II animals.…”

Section: Methodsmentioning

confidence: 99%

“…IHCs are capable of creating spontaneous activity in the auditory nerve (Sewell 1984), which can affect the way in which the nerve responds to electrical stimulation (Wilson 1997;Haenggeli et al 1998;Hu et al 2003). If hair cells FIG.…”

Section: Fig 10mentioning

confidence: 99%

“…It is also possible that the radial component of the electrical current results in direct excitation of the peripheral process and/or the IHC (van den Honert and Stypulkowski 1984). Furthermore, IHCs might generate spontaneous activity in the auditory nerve, which, by desynchronizing the population of auditory nerve fibers, may affect the across-fiber synchrony or the size of the neural population activated by the electrical stimulation (Wilson 1997;Haenggeli et al 1998;Hu et al 2003). The presence of hair cells might also have an indirect effect by supporting the survival of neural elements that affect electrical hearing, such as spiral ganglion neurons (SGNs;Spoendlin 1984;Green et al 2008).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of Hearing Preservation on Psychophysical Responses to Cochlear Implant Stimulation

Kang

Colesa

Swiderski

et al. 2009

JARO

View full text Add to dashboard Cite

Previous studies have shown that residual acoustic hearing supplements cochlear implant function to improve speech recognition in noise as well as perception of music. The current study had two primary objectives. First, we sought to determine how cochlear implantation and electrical stimulation over a time period of 14 to 21 months influence cochlear structures such as hair cells and spiral ganglion neurons. Second, we sought to investigate whether the structures that provide acoustic hearing also affect the perception of electrical stimulation. We compared psychophysical responses to cochlear implant stimulation in two groups of adult guinea pigs. Group I (11 animals) received a cochlear implant in a previously untreated ear, while group II (ten animals) received a cochlear implant in an ear that had been previously infused with neomycin to destroy hearing. Psychophysical thresholds were measured in response to pulse-train and sinusoidal stimuli. Histological analysis of all group I animals and a subset of group II animals was performed. Nine of the 11 group I animals showed survival of the organ of Corti and spiral ganglion neurons adjacent to the electrode array. All group I animals showed survival of these elements in regions apical to the electrode array. Group II animals that were examined histologically showed complete loss of the organ of Corti in regions adjacent and apical to the electrode array and severe spiral ganglion neuron loss, consistent with previous reports for neomycin-treated ears. Behaviorally, group II animals had significantly lower thresholds than group I animals in response to 100 Hz sinusoidal stimuli. However, group I animals had significantly lower thresholds than group II animals in response to pulse-train stimuli (0.02 ms/phase; 156 to 5,000 pps). Additionally, the two groups showed distinct threshold versus pulse rate functions. We hypothesize that the differences in detection thresholds between groups are caused by the electrical activation of the hair cells in group I animals and/or differences between groups in the condition of the spiral ganglion neurons.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Fig 10mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of Hearing Preservation on Psychophysical Responses to Cochlear Implant Stimulation

Kang

Colesa

Swiderski

et al. 2009

JARO

View full text Add to dashboard Cite

show abstract

“…Responsiveness of the auditory nerve can decrease over the course of repeated electric stimulation (Haenggeli et al, 1998;Matsuoka et al, 2000). Our previous study of masking of the ECAP with acoustic noise demonstrated that the magnitude of the masking effect decreased with the probe pulse stimulation rate .…”

Section: Aims and Hypothesesmentioning

confidence: 99%

“…However, such a paradigm would be prohibitively slow for obtaining a reasonable temporal resolution. An electric pulse rate of 5 pps was expected to produce no significant adaptation effects (Haenggeli et al, 1998;Matsuoka et al, 2000), so we chose such a low rate pulse train as the probe stimulus in the present study. As responses to each individual electric pulse within such a train are expected to be independent from preceding pulses, these stimuli were referred to as single pulses throughout the manuscript.…”

Section: Aims and Hypothesesmentioning

confidence: 99%

Acoustic–electric interactions in the guinea pig auditory nerve: Simultaneous and forward masking of the electrically evoked compound action potential

et al. 2007

View full text Add to dashboard Cite

The study investigated the time course of the effects of acoustic and electric stimulation on the electrically evoked compound action potential (ECAP). Adult guinea pigs were used in acute experimental sessions. Bursts of acoustic noise and high-rate (5000 pulses/s) electric pulse trains were used as maskers. Biphasic electric pulses were used as probes. ECAPs were recorded from the auditory nerve trunk.Simultaneous masking of the ECAP with acoustic noise featured an onset effect and a decrease in the amount of masking to a steady state. It was characterized by a two-component exponential function. The amount of masking increased with masker level and decreased with probe level. Poststimulatory ECAP recovery often featured a non-monotonic time course, described by a threecomponent exponent. Electric maskers produced similar post-stimulatory effects in hearing and acutely deafened subjects.Acoustic stimulation affects the ECAP in a level-and time-dependent manner. Simultaneous masking follows a time course comparable to that of adaptation to an acoustic stimulus. Refractoriness, spontaneous activity, and adaptation are suggested to play a role in ECAP recovery. Post-stimulatory changes in synchrony, possibly due to recovery of spontaneous activity and an additional hair-cell independent mechanism, are hypothesized to contribute to the observed non-monotonicity of recovery.

show abstract

Neurobiology

Modern Acoustics and Signal Processing

View full text Add to dashboard Cite

Electrically Evoked Compound Action Potential (ECAP) of the Cochlear Nerve in Response to Pulsatile Electrical Stimulation of the Cochlea in the Rat: Effects of Stimulation at High Rates

Cited by 39 publications

References 43 publications

Effects of Hearing Preservation on Psychophysical Responses to Cochlear Implant Stimulation

Effects of Hearing Preservation on Psychophysical Responses to Cochlear Implant Stimulation

Acoustic–electric interactions in the guinea pig auditory nerve: Simultaneous and forward masking of the electrically evoked compound action potential

Neurobiology

Contact Info

Product

Resources

About