Electrically Evoked Auditory Steady-State Responses in a Guinea Pig Model: Latency Estimates and Effects of Stimulus Parameters

Jeng, Fuh-Cherng; Abbas, Paul J.; Brown, Carolyn J.; Miller, Charles A.; Nourski, Kirill V.; Robinson, Barbara K.

doi:10.1159/000112424

Cited by 8 publications

(4 citation statements)

References 64 publications

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“…Electrophysiological measures from the periphery could potentially be complementary to the more central measures and can provide insight where in the auditory pathway TEM encoding is affected. Studies have shown that ECAPs can be obtained to each pulse of a modulated pulse trains both in animals 56 and humans 57 . Jeng et al 56 found that the electrically-evoked compound action potential (eCAP) modulated response amplitudes (i.e.…”

Section: Discussionmentioning

confidence: 99%

“…Studies have shown that ECAPs can be obtained to each pulse of a modulated pulse trains both in animals 56 and humans 57 . Jeng et al 56 found that the electrically-evoked compound action potential (eCAP) modulated response amplitudes (i.e. difference between the minimum and maximum eCAP amplitudes across a modulated cycle) show a compressive non-linear growth with increasing modulation depths, which is in line with the 40-Hz eASSR growth functions that we observed.…”

Section: Discussionmentioning

confidence: 99%

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Electrophysiological assessment of temporal envelope processing in cochlear implant users

Gransier

Carlyon

Wouters

2020

Sci Rep

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Cochlear-implant (CI) users rely on temporal envelope modulations (TEMs) to understand speech, and clinical outcomes depend on the accuracy with which these TEMs are encoded by the electrically-stimulated neural ensembles. Non-invasive EEG measures of this encoding could help clinicians identify and disable electrodes that evoke poor neural responses so as to improve CI outcomes. However, recording EEG during CI stimulation reveals huge stimulation artifacts that are up to orders of magnitude larger than the neural response. Here we used a custom-built EEG system having an exceptionally high sample rate to accurately measure the artefact, which we then removed using linear interpolation so as to reveal the neural response during continuous electrical stimulation. In ten adult CI users, we measured the 40-Hz electrically evoked auditory steady-state response (eASSR) and electrically evoked auditory change complex (eACC) to amplitude-modulated 900-pulses-per-second pulse trains, stimulated in monopolar mode (i.e. the clinical default), and at different modulation depths. We successfully measured artifact-free 40-Hz eASSRs and eACCs. Moreover, we found that the 40-Hz eASSR, in contrast to the eACC, showed substantial responses even at shallow modulation depths. We argue that the 40-Hz eASSR is a clinically feasible objective measure to assess TEM encoding in CI users.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Electrophysiological assessment of temporal envelope processing in cochlear implant users

Gransier

Carlyon

Wouters

2020

Sci Rep

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“…During the last decade several investigators have also looked at the efficacy of recording electrically evoked auditory steady state responses (EASSRs) in CI recipients. Some of these have been animal studies (Jeng et al, 2007(Jeng et al, , 2008, while others have been human studies (Ménard et al, 2004;Yang et al, 2008;Hofmann and Wouters, 2010). One consistent problem that has occurred in recording EASSRs across studies has been electrical artifact contamination produced by stimulus pulses and radio frequency (RF) transmission, especially at high stimulus intensities.…”

Section: Potential Clinical Applications Of the Assrmentioning

confidence: 99%

Auditory Steady-State Responses

Korczak

Smart²,

Delgado³

et al. 2012

J Am Acad Audiol

115

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Most researchers agree that, in the future, ASSR testing will play an important role in clinical audiology. Therefore, it is important for clinical audiologists and Au.D. students to have a good basic understanding of the technical concepts associated with the ASSR, a knowledge of optimal stimulus and recording parameters used to accurately record this response, and an appreciation of the current role and/or limitations of using the ASSR to estimate behavioral thresholds in infants with various degrees and configurations of hearing loss.

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“…The temporal properties of neural responses, ie., the decline of the neural response following stimulus repetition (e.g., pulse trains) and the neural recovery from preceding stimuli provide information regarding neural encoding of temporal cues [11,12]. When stimuli are repeatedly presented, neural responses decrease over time.…”

Section: Introductionmentioning

confidence: 99%

Neural Adaptation and Behavioral Measures of Temporal Processing and Speech Perception in Cochlear Implant Recipients

et al. 2013

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The objective was to determine if one of the neural temporal features, neural adaptation, can account for the across-subject variability in behavioral measures of temporal processing and speech perception performance in cochlear implant (CI) recipients. Neural adaptation is the phenomenon in which neural responses are the strongest at the beginning of the stimulus and decline following stimulus repetition (e.g., stimulus trains). It is unclear how this temporal property of neural responses relates to psychophysical measures of temporal processing (e.g., gap detection) or speech perception. The adaptation of the electrical compound action potential (ECAP) was obtained using 1000 pulses per second (pps) biphasic pulse trains presented directly to the electrode. The adaptation of the late auditory evoked potential (LAEP) was obtained using a sequence of 1-kHz tone bursts presented acoustically, through the cochlear implant. Behavioral temporal processing was measured using the Random Gap Detection Test at the most comfortable listening level. Consonant nucleus consonant (CNC) word and AzBio sentences were also tested. The results showed that both ECAP and LAEP display adaptive patterns, with a substantial across-subject variability in the amount of adaptation. No correlations between the amount of neural adaptation and gap detection thresholds (GDTs) or speech perception scores were found. The correlations between the degree of neural adaptation and demographic factors showed that CI users having more LAEP adaptation were likely to be those implanted at a younger age than CI users with less LAEP adaptation. The results suggested that neural adaptation, at least this feature alone, cannot account for the across-subject variability in temporal processing ability in the CI users. However, the finding that the LAEP adaptive pattern was less prominent in the CI group compared to the normal hearing group may suggest the important role of normal adaptation pattern at the cortical level in speech perception.

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Electrically Evoked Auditory Steady-State Responses in a Guinea Pig Model: Latency Estimates and Effects of Stimulus Parameters

Cited by 8 publications

References 64 publications

Electrophysiological assessment of temporal envelope processing in cochlear implant users

Electrophysiological assessment of temporal envelope processing in cochlear implant users

Auditory Steady-State Responses

Neural Adaptation and Behavioral Measures of Temporal Processing and Speech Perception in Cochlear Implant Recipients

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