Electrically controlled release of ibuprofen from conductive poly(3-methoxydiphenylamine)/crosslinked pectin hydrogel

Mongkolkitikul, Sirivipa; Paradee, Nophawan; Sirivat, Anuvat

doi:10.1016/j.ejps.2017.10.043

Cited by 41 publications

(29 citation statements)

References 45 publications

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“…Drug release systems are devices that bring about a therapeutic agent in the body with improved efficiency and safety by regulating the speed, timing, and location of drug releasing . Transdermal drug delivery system (TDDS) is a forward drug delivery strategy that has many advantages when compared to oral or hypodermic injection . TDDS can control drug release with a fixed blood level profile during treatment.…”

Section: Introductionmentioning

confidence: 99%

“…TDDS can control drug release with a fixed blood level profile during treatment. In addition, TDDS is painless and user friendly and also has improved patient compliance . Despite the many advantages of TDDS, the outer layer of the skin (stratum corneum) creates a barrier for drug release and slows the release.…”

Section: Introductionmentioning

confidence: 99%

“…Despite the many advantages of TDDS, the outer layer of the skin (stratum corneum) creates a barrier for drug release and slows the release. One of the most effective ways to overcome this barrier and increase the release is to apply the electric field . Therefore, the biomaterials to be used in TDDS are generally electrically sensitive.…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3][4][5] Transdermal drug delivery system (TDDS) is a forward drug delivery strategy that has many advantages when compared to oral or hypodermic injection. [6][7][8][9] TDDS can control drug release with a fixed blood level profile during treatment. In addition, TDDS is painless and user friendly and also has improved patient compliance.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, TDDS is painless and user friendly and also has improved patient compliance. 8,9 Despite the many advantages of TDDS, the outer layer of the skin (stratum corneum) creates a barrier for drug release and slows the release. One of the most effective ways to overcome this barrier and increase the release is to apply the electric field.…”

Section: Introductionmentioning

confidence: 99%

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Electrically controlled release of 5‐fluorouracil from conductive gelatin methacryloyl‐based hydrogels

Oktay

Alemdar

2018

J of Applied Polymer Sci

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Herein, electro‐responsive hydrogels were obtained by incorporation of poly(3,4‐ethylenedioxythiophene)/poly(styrenesulfonate) (PEDOT/PSS) into the gelatin methacryloyl (GelMA) by using photopolymerization technique. Hydrogels were characterized by FTIR and scanning electron microscopy analyses. Cytotoxicity tests were performed by L929 cell lines to determine cell compatibility. Swelling tests were conducted to investigate the water uptake capacity of hydrogels. 5‐fluorouracil (5‐FU) was selected as a model drug as it is known as a topical drug for some skin cancer type treatment. The release of 5‐FU from the hydrogel was provided in efficient and controlled manner at simulated skin cancer (pH = 5.5) and under 0 and 1.5 V. The simulated drug delivery experiments conducted in vitro revealed that the drug releasing amount was higher when voltage is applied to the hydrogels. All results visualized that the obtained GelMA‐based PEDOT/PSS hydrogels with enhanced electrical properties could be a potential candidate as an electrically sensitive drug carrier for treatment of skin cancer in the future applications. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 46914.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Electrically controlled release of 5‐fluorouracil from conductive gelatin methacryloyl‐based hydrogels

Oktay

Alemdar

2018

J of Applied Polymer Sci

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Electrically Controlled Biochemical Release from Micro/Nanostructures for in vitro and in vivo Applications: A Review

Guo

Fan

2018

ChemNanoMat

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To release biosubstances, including drug molecules, DNAs, and proteins, at prescribed cellular and tissue locations with controllable rates is the Holy Grail of drug delivery that could enable an array of unprecedented in vitro and in vivo applications. Extensive research efforts have been focused on exploring innovative mechanisms and approaches for controlling biochemical release with prescribed dose, timing, and dynamics. Particularly, the utilization of electric fields to stimulate the release of biomolecules from synthesized micro/nanostructures has received considerable interest. In this review, we focus on the recent progresses in controlling the release of biomolecules with electric fields by a variety of mechanisms, including electrochemical desorption and actuation, electrically triggered erosion, and electrically driven nanopumps and mechanical motions. The research on external electric stimuli trigged biorelease has progressed rapidly and could make remarkable impact in single‐cell biology, cell‐cell communication, and drug discovery.

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Electrically controlled transdermal delivery of naproxen and indomethacin from porous cis‐1,4‐polyisoprene matrix

et al. 2021

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This study is focused on the inquiry of using a porous polymeric structure to absorb and release transdermally two drugs through a skin from deproteinized natural rubber latex (DPNR). The porous DPNR films were fabricated from the internal formation of surfactant micelles and their subsequent leaching out to generate porous structures. The pore size of DPNR films increased with increasing surfactant amount. The model drugs were naproxen and indomethacin; their releases and release‐permeations were investigated under the effects of surfactant amount, electrical potential, and drug size. Without electric field, the drug release mechanism was mainly driven by concentration gradient. The higher amount of drug released was obtained from the matrix with a larger pore size. Under electric field, the higher amounts of drug release were obtained in the shorter drug release durations, via the electrorepulsive force between the negatively charged drugs and the cathode electrode. The molecular drug size was a factor for the drug absorption, release rate and amount. For the drug release‐permeation experiment through the pig skin, there were two release‐permeation periods as governed by the combination of concentration gradient and swelling in the first period, and the matrix erosion in the second period. The fabricated porous DPNR films have been shown here to be potential to be used as a transdermal patch with electrically controllable drug release rate, amount and duration along with the facile drug‐matrix loading and absorption.

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Electrically controlled release of ibuprofen from conductive poly(3-methoxydiphenylamine)/crosslinked pectin hydrogel

Cited by 41 publications

References 45 publications

Electrically controlled release of 5‐fluorouracil from conductive gelatin methacryloyl‐based hydrogels

Electrically controlled release of 5‐fluorouracil from conductive gelatin methacryloyl‐based hydrogels

Electrically Controlled Biochemical Release from Micro/Nanostructures for in vitro and in vivo Applications: A Review

Electrically controlled transdermal delivery of naproxen and indomethacin from porous cis‐1,4‐polyisoprene matrix

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