Electrically Controlled Molecular Recognition Harnessed to Activate a Cellular Response

Artzy‐Schnirman, Arbel; Blat, Dan; Talmon, Y.; Fishler, Rami; Gertman, Dori; Oren, Ravit; Wolchinsky, Ron; Waks, Tova; Benhar, Itai; Eshhar, Zelig; Sivan, Uri; Reiter, Yoram

doi:10.1021/nl202971r

Cited by 8 publications

(5 citation statements)

References 14 publications

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“…Sivan, Reiter, and coworkers demonstrated a well designed system that could control cell activation coupled with molecular recognition on the surfaces. 192 Application of a positive bias to the gold electrode switched the monolayer from hydroquinone to benzoquinone. T-cell receptors recognize the latter species on the surface, resulting in activation of the cells.…”

Section: Sensing and Detection At Interfacesmentioning

confidence: 99%

Molecular recognition: from solution science to nano/materials technology

Ariga¹,

Itô²,

Hill³

et al. 2012

Chem. Soc. Rev.

394

188

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In the 25 years since its Nobel Prize in chemistry, supramolecular chemistry based on molecular recognition has been paid much attention in scientific and technological fields. Nanotechnology and the related areas seek breakthrough methods of nanofabrication based on rational organization through assembly of constituent molecules. Advanced biochemistry, medical applications, and environmental and energy technologies also depend on the importance of specific interactions between molecules. In those current fields, molecular recognition is now being re-evaluated. In this review, we re-examine current trends in molecular recognition from the viewpoint of the surrounding media, that is (i) the solution phase for development of basic science and molecular design advances; (ii) at nano/materials interfaces for emerging technologies and applications. The first section of this review includes molecular recognition frontiers, receptor design based on combinatorial approaches, organic capsule receptors, metallo-capsule receptors, helical receptors, dendrimer receptors, and the future design of receptor architectures. The following section summarizes topics related to molecular recognition at interfaces including fundamentals of molecular recognition, sensing and detection, structure formation, molecular machines, molecular recognition involving polymers and related materials, and molecular recognition processes in nanostructured materials.

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Section: Sensing and Detection At Interfacesmentioning

confidence: 99%

Molecular recognition: from solution science to nano/materials technology

Ariga¹,

Itô²,

Hill³

et al. 2012

Chem. Soc. Rev.

394

188

View full text Add to dashboard Cite

show abstract

“…Antibodies against C 60 [37,38], 1,4-dinitrobenzene [39], leucine-leucine-tyrosine crystals [39][40][41], and cholesterol monohydrate crystals [42][43][44][45] were isolated this way. Finally, single chain Fv (ScFv) phage display libraries have been successfully employed to isolate antibodies against gallium arsenide (GaAs) (111A) [19], benzoquinone monolayer on gold [46,47], and Cu(II) [48].…”

Section: Introductionmentioning

confidence: 99%

On the limited recognition of inorganic surfaces by short peptides compared with antibodies

Artzy‐Schnirman

Abu-Shah

Dishon

et al. 2014

Journal of Peptide Science

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The vast potential applications of biomolecules that bind inorganic surfaces led mostly to the isolation of short peptides that target selectively specific materials. The demonstrated differential affinity toward certain surfaces created the impression that the recognition capacity of short peptides may match that of rigid biomolecules. In the following, we challenge this view by comparing the capacity of antibody molecules to discriminate between the (100) and (111A) facets of a gallium arsenide semiconductor crystal with the capacity of short peptides to do the same. Applying selection from several peptide and single chain phage display libraries, we find a number of antibody molecules that bind preferentially a given crystal facet but fail to isolate, in dozens of attempts, a single peptide capable of such recognition. The experiments underscore the importance of rigidity to the recognition of inorganic flat targets and therefore set limitations on potential applications of short peptides in biomimetics.

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“…4A). 102 A related platform was recently reported to modulate cell–substrate and cell–cell interactions. 103 Unlike previous work, the hydroquinone-based electroactive groups were directly modified on the cell membranes through liposome–cell fusion (Fig.…”

Section: The Various Stimuli-responsive Platforms and Their Applicati...mentioning

confidence: 99%

Manipulating cell fate: dynamic control of cell behaviors on functional platforms

et al. 2018

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Electrically Controlled Molecular Recognition Harnessed to Activate a Cellular Response

Cited by 8 publications

References 14 publications

Molecular recognition: from solution science to nano/materials technology

Molecular recognition: from solution science to nano/materials technology

On the limited recognition of inorganic surfaces by short peptides compared with antibodies

Manipulating cell fate: dynamic control of cell behaviors on functional platforms

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