Electrically conducting polymers for bio-interfacing electronics: From neural and cardiac interfaces to bone and artificial tissue biomaterials

Lee, Seunghyeon; Ozlu, Busra; Eom, Taesik; Martin, David C.; Shim, Bong Sup

doi:10.1016/j.bios.2020.112620

Cited by 57 publications

(50 citation statements)

References 184 publications

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“…From in vivo testing in rabbits, both glucose concentration and intraocular pressure, which can be detected using a resonant frequency, could be collected by bringing the probe into contact with the eyes. Furthermore, many engineering technologies, such as neural interface technologies [74], electronic skin (e-skin) [75,76], implantable electronics [77], and electroceuticals [78], provide significant advantages for various biomedical applications, including the monitoring and treatment of dementia [79]. However, several issues, including long-term biocompatibility and safety issues with new drugs, remain challenges.…”

Section: Monitoring Systemmentioning

confidence: 99%

Personalized Healthcare for Dementia

2021

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Dementia is one of the most common health problems affecting older adults, and the population with dementia is growing. Dementia refers to a comprehensive syndrome rather than a specific disease and is characterized by the loss of cognitive abilities. Many factors are related to dementia, such as aging, genetic profile, systemic vascular disease, unhealthy diet, and physical inactivity. As the causes and types of dementia are diverse, personalized healthcare is required. In this review, we first summarize various diagnostic approaches associated with dementia. Particularly, clinical diagnosis methods, biomarkers, neuroimaging, and digital biomarkers based on advances in data science and wearable devices are comprehensively reviewed. We then discuss three effective approaches to treating dementia, including engineering design, exercise, and diet. In the engineering design section, recent advances in monitoring and drug delivery systems for dementia are introduced. Additionally, we describe the effects of exercise on the treatment of dementia, especially focusing on the effects of aerobic and resistance training on cognitive function, and the effects of diets such as the Mediterranean diet and ketogenic diet on dementia.

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Section: Monitoring Systemmentioning

confidence: 99%

Personalized Healthcare for Dementia

2021

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“…CPs hold favourable characteristics, such as electronic–ionic hybrid conductivity, mechanical softness, permeable porosity, and versatile chemical modification. This means they are recommended for a wide range of biomedical applications, including biosensors, chemical sensors, drug delivery systems, artificial muscles, and neural interfaces [ 105 ]. Additionally, CPs are utilized in the application of artificial muscles, due to their electrochemical deformation properties.…”

Section: Current Developments Of Polymeric Materials For Biomedical Applicationsmentioning

confidence: 99%

Advocating Electrically Conductive Scaffolds with Low Immunogenicity for Biomedical Applications: A Review

et al. 2021

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Scaffolds support and promote the formation of new functional tissues through cellular interactions with living cells. Various types of scaffolds have found their way into biomedical science, particularly in tissue engineering. Scaffolds with a superior tissue regenerative capacity must be biocompatible and biodegradable, and must possess excellent functionality and bioactivity. The different polymers that are used in fabricating scaffolds can influence these parameters. Polysaccharide-based polymers, such as collagen and chitosan, exhibit exceptional biocompatibility and biodegradability, while the degradability of synthetic polymers can be improved using chemical modifications. However, these modifications require multiple steps of chemical reactions to be carried out, which could potentially compromise the end product’s biosafety. At present, conducting polymers, such as poly(3,4-ethylenedioxythiophene) poly(4-styrenesulfonate) (PEDOT: PSS), polyaniline, and polypyrrole, are often incorporated into matrix scaffolds to produce electrically conductive scaffold composites. However, this will reduce the biodegradability rate of scaffolds and, therefore, agitate their biocompatibility. This article discusses the current trends in fabricating electrically conductive scaffolds, and provides some insight regarding how their immunogenicity performance can be interlinked with their physical and biodegradability properties.

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“…Moxon et al [ 86 ] demonstrate that inclusion of collagen fibrils within alginate hydrogels acts dually to support neuronal culture by increasing stiffness whilst also improving bioactivity. Hybrid hydrogels have become increasingly attractive when considering the limited biocompatibility of conductive polymers [ 68 , 87 , 88 ]. Inclusion of conductive elements is important as inhibition of electrical signalling by biomaterials can impede nervous tissue function [ 88 ].…”

Section: Biomaterialsmentioning

confidence: 99%

“…Conductivity is another important consideration for CNS biomaterials. Inclusion of carbon components (crystals, nanotubes, wires, sheets, nanoclays) improves conductivity and promotes network functionality [ 68 , 71 , 87 , 101 , 102 ], and has been shown to regulate cellular differentiation and network stabilisation [ 26 , 45 ]. Inclusion of conductive components also enables integrated analysis of neuronal network activity [ 58 ].…”

Section: Biomaterialsmentioning

confidence: 99%

Modelling the central nervous system: tissue engineering of the cellular microenvironment

Walczak

Esteban

Bassett

et al. 2021

Emerging Topics in Life Sciences

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With the increasing prevalence of neurodegenerative diseases, improved models of the central nervous system (CNS) will improve our understanding of neurophysiology and pathogenesis, whilst enabling exploration of novel therapeutics. Studies of brain physiology have largely been carried out using in vivo models, ex vivo brain slices or primary cell culture from rodents. Whilst these models have provided great insight into complex interactions between brain cell types, key differences remain between human and rodent brains, such as degree of cortical complexity. Unfortunately, comparative models of human brain tissue are lacking. The development of induced Pluripotent Stem Cells (iPSCs) has accelerated advancement within the field of in vitro tissue modelling. However, despite generating accurate cellular representations of cortical development and disease, two-dimensional (2D) iPSC-derived cultures lack an entire dimension of environmental information on structure, migration, polarity, neuronal circuitry and spatiotemporal organisation of cells. As such, researchers look to tissue engineering in order to develop advanced biomaterials and culture systems capable of providing necessary cues for guiding cell fates, to construct in vitro model systems with increased biological relevance. This review highlights experimental methods for engineering of in vitro culture systems to recapitulate the complexity of the CNS with consideration given to previously unexploited biophysical cues within the cellular microenvironment.

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Electrically conducting polymers for bio-interfacing electronics: From neural and cardiac interfaces to bone and artificial tissue biomaterials

Cited by 57 publications

References 184 publications

Personalized Healthcare for Dementia

Personalized Healthcare for Dementia

Advocating Electrically Conductive Scaffolds with Low Immunogenicity for Biomedical Applications: A Review

Modelling the central nervous system: tissue engineering of the cellular microenvironment

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