Electrical stimulation to promote osteogenesis using conductive polypyrrole films

Electrophoretic deposition to promote layer-by-layer assembly for in situ gene delivery application

“…Fabricated PPy films demonstrated biocompatibility, and their transparency is beneficial for investigations of surface cell morphology [15]. In the present study, successful preparation of chitosan/DNA multilayers on PPy films was confirmed using FTIR spectrometry (Fig.…”

“…However, these electrodes are not frequently used as implant materials, and their clinical applications are limited [9][10][11][12]14]. In a previous study, we fabricated conductive polypyrrole (PPy) films that are biocompatible and transparent, allowing easy observation of surface cells [15]. These films can also be directly deposited onto material surfaces, suggesting potential use for surface modification of clinical implants.…”

Electrically responsive microreservoires for controllable delivery of dexamethasone in bone tissue engineering

“…For orthopedic implants, a particular attention has been dedicated to electrical stimulation (ES) [15][16][17]. ES of cells is a powerful tool for tissue engineering, with positive effects on the adhesion, proliferation and differentiation of cells from the nervous system, skin, bones and muscles [18][19][20][21]. Numerous studies particularly evidenced the positive roles that the electrical stimuli applied through conductive substrates such as metals, graphenes and conductive polymers exerts on the process of bone regeneration [19][20][21].…”

“…ES of cells is a powerful tool for tissue engineering, with positive effects on the adhesion, proliferation and differentiation of cells from the nervous system, skin, bones and muscles [18][19][20][21]. Numerous studies particularly evidenced the positive roles that the electrical stimuli applied through conductive substrates such as metals, graphenes and conductive polymers exerts on the process of bone regeneration [19][20][21]. In this regard, we recently developed electrically conductive titanium-polypyrrole/poly(lactic-co-glycolic) acid (Ti-PPy/PLGA) constructs and we showed that their electrical stimulation with 200 mA, applied for 4 hours, stimulated the osteogenesis in osteoblast-like cells [22].…”

Lysine-doped polypyrrole/spider silk protein/poly( l -lactic) acid containing nerve growth factor composite fibers for neural application

“…Polypyrrole (PPy) has been the most extensively studied for biological and medical applications, such as biosensors and tissue engineering scaffolds due to its ease of synthesis, cytocompatibility, and good conductivity [1,2]. It has been recognized as a promising scaffold material to electrically stimulate neurons and nerve tissues for therapeutic purposes such as nerve tissue engineering scaffolds [3,4].…”