Electrical stimulation of the piriform cortex for the treatment of epilepsy: A review of the supporting evidence

Young, James C; Vaughan, David N.; Paolini, Antonio G.; Jackson, Graeme D.

doi:10.1016/j.yebeh.2018.09.004

Cited by 22 publications

(18 citation statements)

References 88 publications

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“…In humans, the anatomy and functionality of piriform cortex is less understood. Although it can be divided into frontal- and temporal-lobe subregions (Mai et al, 2015; Vaughan and Jackson, 2014; Young et al, 2018; Allison, 1954), whether these correspond to rodent anterior and posterior subdivisions is unclear. While neuroimaging studies have pointed to functional heterogeneity within human piriform cortex (Bensafi, 2012; Fournel et al, 2016; Gottfried et al, 2002; Howard et al, 2009; Howard and Gottfried, 2014; Li et al, 2008; Porter et al, 2005; Seubert et al, 2013; Zelano et al, 2011; Zelano et al, 2005), its anatomical and functional distinctions are still not clearly defined.…”

Section: Introductionmentioning

confidence: 99%

Characterizing functional pathways of the human olfactory system

Zhou

Lane

Cooper

et al. 2019

eLife

142

111

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The central processing pathways of the human olfactory system are not fully understood. The olfactory bulb projects directly to a number of cortical brain structures, but the distinct networks formed by projections from each of these structures to the rest of the brain have not been well-defined. Here, we used functional magnetic resonance imaging and k-means clustering to parcellate human primary olfactory cortex into clusters based on whole-brain functional connectivity patterns. Resulting clusters accurately corresponded to anterior olfactory nucleus, olfactory tubercle, and frontal and temporal piriform cortices, suggesting dissociable whole-brain networks formed by the subregions of primary olfactory cortex. This result was replicated in an independent data set. We then characterized the unique functional connectivity profiles of each subregion, producing a map of the large-scale processing pathways of the human olfactory system. These results provide insight into the functional and anatomical organization of the human olfactory system.

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Section: Introductionmentioning

confidence: 99%

Characterizing functional pathways of the human olfactory system

Zhou

Lane

Cooper

et al. 2019

eLife

142

111

View full text Add to dashboard Cite

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“…Thus, this region is susceptible to the onset of epileptic seizures. However, these seizures commonly present no motor phenotype, and their clinical condition is restricted to cognitive, motivational, and social aspects 28 - 30 . The c-Fos expression found in the ACAd of the NPS group may be the result of increased activity in other limbic areas with efferent projections to this region.…”

Section: Discussionmentioning

confidence: 99%

“…This region is considered an epileptogenic area involved in frontal lobe epilepsy, which is difficult to control. In this area, interneurons are thought to play an important role in synchronizing electrical activity, and the presence of gap junctions allows for the existence of electrical synapses and, consequently, for synchronized action potentials 28 . Thus, this region is susceptible to the onset of epileptic seizures.…”

Section: C-fos Expression In Seizure-related Areas Of Nps Ratsmentioning

confidence: 99%

C-Fos expression in epileptogenic areas of nephropathic rats undergoing star fruit poisoning

et al. 2020

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“…The piriform cortex is located at the confluence of the temporal and frontal lobes (Fig. 1) around the entorhinal sulcus (Gonçalves et al, 2005;Galovic et al, 2019), with frontal and temporal divisions (Young et al, 2018). The piriform cortex is three layered allocortex, as is the hippocampus (Vaughan et al, 2014).…”

Section: Introductionmentioning

confidence: 99%