Electrical stimulation of cerebellar vermis induces absence epilepsy-like eeg activity in penicillin treated cats

Godlevsky, L. S.; Nenova, O. M.; Voropay, M.; Prybolovets, T. V.; Pervak, Mykhailo

doi:10.1016/j.jns.2017.08.1953

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hence, it might be supposed that influences coming to the forebrain from stimulated paleocerebellum can precipitate EEG signs of AS in the cortical GABA-A mechanism zone disturbed with local penicillin application. This effect of ES is promoted by the increase of GABA-ergic inhibition in target neuronal chains as far as investigated components of seizure discharged (slow wave, PPC) reflect the heightened state of GABA inhibition and developed in parallel with the suppression of spike discharges [43, 47, 48].…”

Section: Discussionmentioning

confidence: 99%

Cerebellar Contribution to Absence Epilepsy

Godlevsky

Pinyazhko

Poshyvak

2020

Preprint

View full text Add to dashboard Cite

The new aggregate data analyses revealed the earlier missing role played by the cerebellum long-term electrical stimulation in the absence epilepsy. Neurophysiologic data gained by authors favor that cerebellar serial deep brain stimulation (DBS) (100 Hz) causes the transformation of penicillin-induced cortical focal discharges into prolonged 3,5-3,75 sec oscillations resembling spike-wave discharges (SWD) in cats. Such SWDs were not organized in the form of bursts and persisted continuously after stimulation. Therefore the appearance of prolonged periods of SWD is regarded as a tonic cerebellar influence upon pacemaker of SWD and might be caused by the long-lasting DBS-induced increase of GABA-ergic extrasynaptic inhibition in forebrain networks. At the same time, cerebellar DBS high-frequency (100 Hz) suppressed bursts of SWD observed during the phase of stimulation. Different types of cerebellar DBS upon epileptic activity emphasized the absence seizure facilitation discussed with the reviewed data on optogenetic stimulation, neuronal activity of cerebellar structures, and functional magnetic resonance imaging data.

show abstract

Section: Discussionmentioning

confidence: 99%