Electrical stimulation in animal models of epilepsy: A review on cellular and electrophysiological aspects

Fiorin, Fernando da Silva; Silva, Mariane de Araújo e; Rodrigues, Abner Cardoso

doi:10.1016/j.lfs.2021.119972

Cited by 5 publications

(3 citation statements)

References 153 publications

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“… Yang et al, 2022 ). TNS has been associated with a protective effect against brain injuries such as epilepsy and is associated with reduced inflammation and apoptosis ( da Silva Fiorin et al, 2021 ; Wang et al, 2016 ). It is plausible that the anti-apoptotic effects of TNS occur via inhibition of NF-ĸB ( Inohara and Nuñez, 2003 ).…”

Section: Pathophysiology Of Pth and Associated Mechanisms After Tbimentioning

confidence: 99%

Inflammation, brain connectivity, and neuromodulation in post-traumatic headache

da Silva Fiorin,

do Espírito Santo,

Da Silva

et al. 2024

Brain, Behavior, & Immunity - Health

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Section: Pathophysiology Of Pth and Associated Mechanisms After Tbimentioning

confidence: 99%

Inflammation, brain connectivity, and neuromodulation in post-traumatic headache

da Silva Fiorin,

do Espírito Santo,

Da Silva

et al. 2024

Brain, Behavior, & Immunity - Health

Self Cite

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“…16 In addition, an approach that is already widely used and has excellent growth potential is DBS, although its mechanism is not yet fully known. 17,18 This consists of implanting electrodes in specific areas of the brain and a neurostimulator under the skin of the patient's chest. When the neurostimulator is activated, it can transmit electrical currents to target regions of the nervous system and thus act on the symptoms of neurological disorders such as Parkinson's, severe depression, epilepsy and Tourette's syndrome.…”

Section: Current Therapeutic Panorama Of Neuroengineeringmentioning

confidence: 99%

“…As device activation occurs only when there is feedback from the change in neurological activity, energy consumption is reduced compared to open-loop systems that continuously deliver signals. 18 Battery-free and wireless devices not only offer greater reliability due to their precision and effectiveness but also involve potential for new applications such as remote monitoring, photonic therapy, and microfluidic drug delivery. 43 Another line of study being developed is neuroprostheses for patients with motor dysfunctions.…”

Section: Future Perspectives and Solutionsmentioning

confidence: 99%

Neuroengineering as an interface for therapeutic development

Santos da Silva,

Nichele KUSMA,

Hetzel VALGINSKI

et al. 2024

BioSCIENCE

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Introduction: Nervous system’s cells, particularly neurons, communicate through neurotransmitters and ionic exchanges that generate electrical currents when receiving an external stimulus or when the system itself transmits information through nerve impulses. Considering the principle that this information can be captured, decoded, and used by devices to restore motor and sensory functions, the field of neuroengineering has significantly advanced in recent years. As a multidisciplinary study area, its development requires aligning knowledge of the electrical functioning of the nervous system with engineering and circuits in order to optimize neuroprosthetics to be increasingly efficient, durable, and safe. Objectives: To map the state of the art in neuroengineering and its nuances based on scientific literature. To identify the main developments, challenges, and opportunities in the future of the field. Methods: A systematic review of literature on the combination of engineering and neuroscience in therapeutic applications was conducted. English texts published between 2012 and 2022, that met pre-determined inclusion criteria, were considered/accepted using the following terms for the research: Robotic prosthesis, Neuroengineering, Electrophysiology, Robotic movement, Neural decodification, Nervous system engineering, Neurophysiology, Neural prosthesis, and Neuroanatomy. Results: The review demonstrated that there are established therapeutic approaches based on neuroengineering, such as deep brain stimulation for alleviating Parkinson's symptoms. However, for some neurodegenerative diseases and nervous system injuries, therapeutic-focused neuroprostheses are still in experimental phases or require adjustments to meet user demands and thus achieving greater acceptance and accuracy. Conclusion: Despite the numerous challenges faced in this early stage of the field’s development, advances in research are already observable due to technological developments allowing the implementation of artificial intelligence, more modern microelectrodes, and a better understanding of the system and adaptation between organism and machine.

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Brain connectivity analysis in preictal phases of seizure induced by pentylenetetrazol in rats

de Araújo e Silva,

Fiorin,

Santiago

et al. 2024

Brain Research

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Electrical stimulation in animal models of epilepsy: A review on cellular and electrophysiological aspects

Cited by 5 publications

References 153 publications

Inflammation, brain connectivity, and neuromodulation in post-traumatic headache

Inflammation, brain connectivity, and neuromodulation in post-traumatic headache

Neuroengineering as an interface for therapeutic development

Brain connectivity analysis in preictal phases of seizure induced by pentylenetetrazol in rats

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