Electrical stimulation for propelling endoscopes

Mosse, Charles A.; Mills, Timothy N.; Appleyard, Mark; Kadirkamanathan, Srinathan; Swain, C. Paul

doi:10.1067/mge.2001.116327

Cited by 54 publications

(32 citation statements)

References 9 publications

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“…[1][2][3]8,11,13 All these experimental studies performed on cats, 3 dogs, 2,4,6,11 and pigs 1,8,10,13 showed promising results and the published stimulation parameters cover a broad range: 10-120 Hz for the frequency, 0.5-70 ms for the pulse width, 7-100 mA for the current amplitude, and 10-30 s for the duration of one stimulation burst. [1][2][3][4]6,8,10,11,13 The objective of this study was to determine the feasibility and methodology to induce colonic contractions using a battery-operated device, with electrodes implanted into the colonic seromuscular layer of anesthetized pigs. Sevcencu et al recently proposed a method of electrical stimulation using low values for stimulation amplitude (15 mA) and pulse duration (3 ms) to induce propulsive contractions on the descending colon of pigs.…”

Section: Introductionmentioning

confidence: 90%

“…Several acute and chronic studies of direct electrical stimulation have been performed over the last decade on different segments of the gastrointestinal tract: (1) electrical stimulation of the stomach for the treatment of gastroparesis, 7,9 (2) electrical stimulation of the small intestine to induce propulsive waves 6 and to initiate local contractions that could propel an endoscope, 10 and (3) direct stimulation of different colonic segments to evacuate a colonic pouch 4 or induce propagating waves. [1][2][3]8,11,13 All these experimental studies performed on cats, 3 dogs, 2,4,6,11 and pigs 1,8,10,13 showed promising results and the published stimulation parameters cover a broad range: 10-120 Hz for the frequency, 0.5-70 ms for the pulse width, 7-100 mA for the current amplitude, and 10-30 s for the duration of one stimulation burst.…”

Section: Introductionmentioning

confidence: 99%

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Direct Electrical Stimulation Using a Battery-Operated Device for Induction and Modulation of Colonic Contractions in Pigs

et al. 2010

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Direct electrical stimulation of the colon offers a promising approach for the induction of propulsive colonic contractions by using an implantable device. The objective of this study was to assess the feasibility to induce colonic contractions using a commercially available battery-operated stimulator (maximum pulse width of 1 ms and maximum amplitude of 10 V). Three pairs of pacing electrodes were inserted into the cecal seromuscular layer of anesthetized pigs. During a first set of in vivo experiments conducted on six animals, a pacing protocol leading to cecum contractions was determined: stimulation bursts with 1 ms pulse width, 10 V amplitude (7-15 mA), 120 Hz frequency, and 30-s burst duration, repeated every 2-5 min. In a second testing phase, an evaluation of the pacing protocol was performed in four animals (120 stimulation bursts in total). By using the battery-operated stimulator, contractions of the cecum and movement of contents could be induced in 92% of all stimulations. A cecal shortening of about 30% and an average intraluminal pressure increase of 10.0 +/- 6.0 mmHg were observed.

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Section: Introductionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Direct Electrical Stimulation Using a Battery-Operated Device for Induction and Modulation of Colonic Contractions in Pigs

et al. 2010

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“…In July 2006, this device received approval by FDA for the sale and use in the United States. Swallowable capsules with active locomotion, based on magnetic actuation and electrical stimulation, have been recently demonstrated (Sendoh et al, 2003;Mosse et al, 2001;Woo et al, 2005;.…”

Section: Future Prospects Of Wce: Better Images Therapy and Active Lmentioning

confidence: 98%

Wireless capsule endoscopy: from diagnostic devices to multipurpose robotic systems

Moglia¹,

Menciassi²,

Schurr

et al. 2006

Biomed Microdevices

222

113

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In the recent past, the introduction of miniaturised image sensors with low power consumption, based on complementary metal oxide semiconductor (CMOS) technology, has allowed the realisation of an ingestible wireless capsule for the visualisation of the small intestine mucosa. The device has received approval from Food and Drug Administration and has gained momentum since it has been more successful than traditional techniques in the diagnosis of small intestine disorders. In 2004 an esophagus specific capsule was launched, while a solution for colon is still under development. However, present solutions suffer from several limitations: they move passively by exploiting peristalsis, are not able to stop intentionally for a prolonged diagnosis, they receive power from an internal battery with short length, and their usage is restricted to one organ, either small bowel or esophagus. However the steady progresses in many branches of engineering, including microelectromechanical systems (MEMS), are envisaged to affect the performances of capsular endoscopy. The near future foreshadows capsules able to pass actively through the whole gastrointestinal tract, to retrieve views from all organs and to perform drug delivery and tissue sampling. In the long term, the advent of robotics could lead to autonomous medical platforms, equipped with the most advanced solutions in terms of MEMS for therapy and diagnosis of the digestive tract. In this review, we discuss the state of the art of wireless capsule endoscopy (WCE): after a description on the current status, we present the most promising solutions.

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“…A blood-sensing algorithm which uses colour pattern recognition has been added to the software to ease detection of blood in the lumen [36]. In experimental studies electrostimulation has been used to move capsule endoscopes, suggesting that remote robotic control is feasible [37], and for the first time wireless images of the gastrointestinal tract have been transmitted from a robotically propelled endoscope [38].…”

Section: Discussionmentioning

confidence: 99%

The Wireless Capsule: New Light in the Darkness

Fritscher-Ravens

Swain

2002

Dig Dis

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The development of wireless capsule endoscopy offers the potential to examine the whole small intestine, with its 5-meter length, and has the advantage of being painless. Using a miniature CMOS camera and a short focal length lens, images are obtained, as the optical window of the capsule sweeps past the gut wall, without requiring air inflation of the gut lumen. The capsule endoscope is propelled by peristalsis through the gastrointestinal tract. The video images are transmitted using radiotelemetry to an array of aerials attached to the body which allows image capture. The images are stored on a small portable recorder carried on a belt and subsequently downloaded for analysis. The system allows more than 7 h of continuous recording of images of the gastrointestinal tract. The patients are free to continue their daily routine during the examination. The capsule endoscope has performed well in trials in patients with difficult gastrointestinal bleeding and in comparative studies with push enteroscopy. It has received both a CE mark and FDA approval for use in patients. It has been used to date in about 4,000 patients. The current clinical data are reviewed.

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Electrical stimulation for propelling endoscopes

Cited by 54 publications

References 9 publications

Direct Electrical Stimulation Using a Battery-Operated Device for Induction and Modulation of Colonic Contractions in Pigs

Direct Electrical Stimulation Using a Battery-Operated Device for Induction and Modulation of Colonic Contractions in Pigs

Wireless capsule endoscopy: from diagnostic devices to multipurpose robotic systems

The Wireless Capsule: New Light in the Darkness

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