Electrical stimulation as a novel tool for regulating cell behavior in tissue engineering

Chen, Cen; Bai, Xue; Ding, Ya-Hui; Lee, In-Seop

doi:10.1186/s40824-019-0176-8

Cited by 290 publications

(273 citation statements)

References 131 publications

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“…The biochemical cues can be obtained by surface coating of scaffolds or products after degradation [ 34 , 35 ]. The biophysical cues (e.g., hardness, strain, hydrostatic pressure, shear stress, cyclic stress, and surface topology) can be given directly by scaffolds or with the help of external fields [ 36 , 37 ]. And there are some aspects that need to be characterized to ensure the feasible scaffolds for cell growth: i) evaluate shape and aperture of scaffolds by microscopy techniques [ 38 ]; ii) determine the porosity by the liquid replacement method [ 39 ]; iii) evaluate the mechanical properties including elastic modulus, breaking strength, and compliance and so on through the corresponding experiments [ 40 ]; iv) evaluate the degradability by calculating the percentage of their residual mass after degradation [ 19 ]; v) evaluate the biocompatibility by combining microscopy techniques and histological staining [ 41 ].…”

Section: Significance and Importance Of Scaffold-based Tissue Engineementioning

confidence: 99%

3D printing of tissue engineering scaffolds: a focus on vascular regeneration

et al. 2021

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Section: Significance and Importance Of Scaffold-based Tissue Engineementioning

confidence: 99%

3D printing of tissue engineering scaffolds: a focus on vascular regeneration

et al. 2021

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“…Such limitations call for the development of new approaches capable of delivering electrical cues via alternative means, either by remote stimulation or through innovative nanomaterials activated by micromotion. Electrically conductive materials provide such an innovative tool, serving as the substrate through which external electrical stimulation is converted into bioelectric signals and delivered to the site ( Chen et al, 2019 ).…”

Section: Mimicking the Electrical Environment Of Bone: Nanomaterialsmentioning

confidence: 99%

Nanostructured Biomaterials for Bone Regeneration

Lyons

Plantz

Hsu

et al. 2020

Front. Bioeng. Biotechnol.

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This review article addresses the various aspects of nano-biomaterials used in or being pursued for the purpose of promoting bone regeneration. In the last decade, significant growth in the fields of polymer sciences, nanotechnology, and biotechnology has resulted in the development of new nano-biomaterials. These are extensively explored as drug delivery carriers and as implantable devices. At the interface of nanomaterials and biological systems, the organic and synthetic worlds have merged over the past two decades, forming a new scientific field incorporating nano-material design for biological applications. For this field to evolve, there is a need to understand the dynamic forces and molecular components that shape these interactions and influence function, while also considering safety. While there is still much to learn about the bio-physicochemical interactions at the interface, we are at a point where pockets of accumulated knowledge can provide a conceptual framework to guide further exploration and inform future product development. This review is intended as a resource for academics, scientists, and physicians working in the field of orthopedics and bone repair.

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“…Additionally, the spreading direction of cells is also affected by the electric field [9]. Some types of cells migrate toward the cathode, while others toward the anode.…”

Section: Introductionmentioning

confidence: 99%

Carbon Nanomaterials for Electro-Active Structures: A Review

et al. 2020

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The use of electrically conductive materials to impart electrical properties to substrates for cell attachment proliferation and differentiation represents an important strategy in the field of tissue engineering. This paper discusses the concept of electro-active structures and their roles in tissue engineering, accelerating cell proliferation and differentiation, consequently leading to tissue regeneration. The most relevant carbon-based materials used to produce electro-active structures are presented, and their main advantages and limitations are discussed in detail. Particular emphasis is put on the electrically conductive property, material synthesis and their applications on tissue engineering. Different technologies, allowing the fabrication of two-dimensional and three-dimensional structures in a controlled way, are also presented. Finally, challenges for future research are highlighted. This review shows that electrical stimulation plays an important role in modulating the growth of different types of cells. As highlighted, carbon nanomaterials, especially graphene and carbon nanotubes, have great potential for fabricating electro-active structures due to their exceptional electrical and surface properties, opening new routes for more efficient tissue engineering approaches.

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Electrical stimulation as a novel tool for regulating cell behavior in tissue engineering

Cited by 290 publications

References 131 publications

3D printing of tissue engineering scaffolds: a focus on vascular regeneration

3D printing of tissue engineering scaffolds: a focus on vascular regeneration

Nanostructured Biomaterials for Bone Regeneration

Carbon Nanomaterials for Electro-Active Structures: A Review

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