Electrical Stimulation and assessment of the induced force in the Denervated Muscle

Gera, Sahil; Gangadharan, Naveen; Navin, BP; Tharion, George; Chalageri, Prashanth H.; Thomas, Raji; Devasahayam, Suresh R.

doi:10.1109/tencon.2019.8929282

Cited by 3 publications

(5 citation statements)

References 10 publications

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“…87 FES supported standing requires the user to have sufficient muscle strength, which is achieved through muscle training. 88,89…”

Section: Resultsmentioning

confidence: 99%

“…87 FES supported standing requires the user to have sufficient muscle strength, which is achieved through muscle training. 88,89 The acupuncture and moxibustion therapy is beneficial to correct the posture, muscle shape and gait of the lower limbs, 90,91 restore the lower limb movement function of patients. 92 In the future, a acupuncture module could be set on the corresponding acupoint according to the position of the human body.…”

Section: Other Medical Methods For Lower Limb Rehabilitationmentioning

confidence: 99%

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Lower limb rehabilitation exoskeleton robot: A review

Zhou

Yang

Xue

2021

Advances in Mechanical Engineering

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Lower limb rehabilitation exoskeleton robots (LLRERs) play a positive role in lower limb rehabilitation and assistance for patients with lower limb disorders, and they are helpful to improve patients’ physical status. More and more experiments pay more attention to the kinematic and dynamic data characteristics of different patient groups. However, it is not clear whether these devices have broad adaptability and their clinical significance, so it is necessary to summarize and analyze these research results. This paper summarizes the LLRERs prototype and product in recent years, also compares the advantages and disadvantages of the theory and technology used in these research, and compares the functional characteristics of the devices, finally summarizes the aspects of the LLRERs to be improved. These devices apply advanced theories, techniques or structures, as well as human kinematics and dynamics data. However, due to the complexity of human body characteristics and movement rules, the theory or technology applied in the study design of LLRERs remains to be further studied, which can be improved in many aspects, such as improve the human-computer cooperation of equipment or carry out clinical trials. This paper can provide reference for researchers and designers in the future study, as well as understanding and selecting LLRERs for all kinds of therapist and patients.

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“…87 FES supported standing requires the user to have sufficient muscle strength, which is achieved through muscle training. 88,89…”

Section: Resultsmentioning

confidence: 99%

Section: Other Medical Methods For Lower Limb Rehabilitationmentioning

confidence: 99%

Lower limb rehabilitation exoskeleton robot: A review

Zhou

Yang

Xue

2021

Advances in Mechanical Engineering

View full text Add to dashboard Cite

show abstract

“…To avoid any electrode reaction at higher EF strength, we have stimulated hMSCs using 1 V/cm intermittently for 10 min/day. The width of positive and negative impulses in square and biphasic signals was adopted based on physiological relevance reported in previous literature (Gera et al, 2019; Nishizawa et al, 2007; Park et al, 2011; Thrivikraman et al, 2016). An improved function of denervated muscle was observed after functional electrical stimulation for one month, using biphasic stimulation with an impulse duration of 120 ms (Gera et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

“…The width of positive and negative impulses in square and biphasic signals was adopted based on physiological relevance reported in previous literature (Gera et al, 2019; Nishizawa et al, 2007; Park et al, 2011; Thrivikraman et al, 2016). An improved function of denervated muscle was observed after functional electrical stimulation for one month, using biphasic stimulation with an impulse duration of 120 ms (Gera et al, 2019 ). In another study, the cytosolic Ca 2+ level in cardiac myocytes was increased when stimulated with monophasic electrical signals of 100 ms (Nishizawa et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Electrical stimulation waveform‐dependent osteogenesis on PVDF/BaTiO₃ composite using a customized and programmable cell stimulator

Panda

Sitaramgupta

Pandya

et al. 2022

Biotech & Bioengineering

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Directing cellular functionalities using biomaterial-based bioelectronic stimulation remains a significant constraint in translating research outcomes to address specific clinical needs. Electrical stimulation is now being clinically used as a therapeutic treatment option to promote bone tissue regeneration and to improve neuromuscular functionalities. However, the nature of the electrical waveforms during the stimulation and underlying biophysical rationale are still not scientifically well explored. Furthermore, bone-mimicking implant-based bioelectrical regulation of osteoinductivity has not been translated to clinics. The present study demonstrates the role of the electrical stimulation waveform to direct differentiation of stem cells on an electroactive polymeric substrate, using monophasic direct current (DC), square waveform, and biphasic waveform. In this regard, an in-house electrical stimulation device has been fabricated for the uninterrupted delivery of programmed electrical signals to stem cells in culture. To provide a functional platform for stem cells to differentiate, barium titanate (BaTiO 3 , BT) reinforced poly (vinylidene difluoride) (PVDF) has been developed with mechanical properties similar to bone. The electrical stimulation of human mesenchymal stem cells (hMSCs) on PVDF/BT composite inhibited proliferation rate at day 7, indicating early commitment for differentiation. The phenotypical characteristics of DC stimulated hMSCs provided signatures of differentiation towards osteogenic lineage, which was subsequently confirmed using alkaline phosphatase assay, collagen deposition, matrix mineralization, and genetic expression. Our findings suggest that DC stimulation induced early osteogenesis in hMSCs with a higher level of intracellular reactive oxygen species (ROS), whereas the stimulation with square wave directed late osteogenesis with a lower ROS regeneration. In summary, the present study critically analyzes the role of electrical stimulation waveforms in regulating osteogenesis, without external biochemical differentiation inducers, on a bonemimicking functional biomaterial substrate. Such a strategy can potentially be adopted to develop orthopedic implant-based bioelectronic medicine for bone regeneration.

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“…The muscle stimulator used in the study is an 8-channel electrical stimulator designed in the Bioengineering Department of Christian Medical College and Hospital, Vellore, India [ 33 ]. This is a portable device that has been used for functional electrical stimulation in various departments of the hospital.…”

Section: Methodsmentioning

confidence: 99%

Encoder-Controlled Functional Electrical Stimulator for Bilateral Wrist Activities—Design and Evaluation

2022

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Upper limb impairment following stroke is often characterized by limited voluntary control in the affected arm. In addition, significant motor coordination problems occur on the unaffected arm due to avoidance of performing bilateral symmetrical activities. Rehabilitation strategies should, therefore, not only aim at improving voluntary control on the affected arm, but also contribute to synchronizing activity from both upper limbs. The encoder-controlled functional electrical stimulator, described in this paper, implements precise contralateral control of wrist flexion and extension with electrical stimulation. The stimulator is calibrated for each individual to obtain a table of stimulation parameters versus wrist angle. This table is used to set stimulation parameters dynamically, based on the difference in wrist angle between the set and stimulated side, which is continuously monitored. This allows the wrist on the stimulated side to follow flexion and extension patterns on the set side, thereby mirroring wrist movements of the normal side. This device also gives real-time graphical feedback on how the stimulated wrist is performing in comparison to the normal side. A study was performed on 25 normal volunteers to determine how closely wrist movements on the set side were being followed on the stimulated side. Graphical results show that there were minor differences, which were quantified by considering the peak angles of flexion and extension on the set and stimulated side for each participant. The mean difference in peak flexion and extension range of movement was 2.3 degrees and 1.9 degrees, respectively, with a mean time lag of 1 s between the set and the stimulated angle graphs.

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Electrical Stimulation and assessment of the induced force in the Denervated Muscle

Cited by 3 publications

References 10 publications

Lower limb rehabilitation exoskeleton robot: A review

Lower limb rehabilitation exoskeleton robot: A review

Electrical stimulation waveform‐dependent osteogenesis on PVDF/BaTiO₃ composite using a customized and programmable cell stimulator

Encoder-Controlled Functional Electrical Stimulator for Bilateral Wrist Activities—Design and Evaluation

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Electrical Stimulation and assessment of the induced force in the Denervated Muscle

Cited by 3 publications

References 10 publications

Lower limb rehabilitation exoskeleton robot: A review

Lower limb rehabilitation exoskeleton robot: A review

Electrical stimulation waveform‐dependent osteogenesis on PVDF/BaTiO3 composite using a customized and programmable cell stimulator

Encoder-Controlled Functional Electrical Stimulator for Bilateral Wrist Activities—Design and Evaluation

Contact Info

Product

Resources

About

Electrical stimulation waveform‐dependent osteogenesis on PVDF/BaTiO₃ composite using a customized and programmable cell stimulator