Electrical resonance and membrane currents in turtle cochlear hair cells

Art, Jonathan; Crawford, A. C.; Fettiplace, Robert

doi:10.1016/0378-5955(86)90073-0

Cited by 70 publications

(34 citation statements)

References 15 publications

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“…Data were obtained by electron microscopy except for those obtained by immunofluorescence tance) currents are activated within hundreds of microseconds and have been implicated in shortening the hair cell membrane time constant required for high temporal precision sound coding, in limiting of the receptor potential, and in electrical frequency tuning (in non-mammalian hair cells). Electrical hair cell tuning to a certain stimulus frequency builds on a intimate interplay of BK and Ca 2+ channels, which require close spatial colocalization, most likely at the active zones (Lewis and Hudspeth 1983;Art et al 1986;Fuchs et al 1988;Roberts et al 1990;Tucker and Fettiplace 1995). This has fostered the use of BK channels as a readout of active zone Ca 2+ signaling of hair cells (see next section).…”

Section: Ion Channels Affecting Hair Cell Presynaptic Functionmentioning

confidence: 96%

Hair cell ribbon synapses

2006

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Hearing and balance rely on the faithful synaptic coding of mechanical input by the auditory and vestibular hair cells of the inner ear. Mechanical deflection of their stereocilia causes the opening of mechanosensitive channels, resulting in hair cell depolarization, which controls the release of glutamate at ribbon-type synapses. Hair cells have a compact shape with strong polarity. Mechanoelectrical transduction and active membrane turnover associated with stereociliar renewal dominate the apical compartment. Transmitter release occurs at several active zones along the basolateral membrane. The astonishing capability of the hair cell ribbon synapse for temporally precise and reliable sensory coding has been the subject of intense investigation over the past few years. This research has been facilitated by the excellent experimental accessibility of the hair cell. For the same reason, the hair cell serves as an important model for studying presynaptic Ca(2+) signaling and stimulus-secretion coupling. In addition to common principles, hair cell synapses differ in their anatomical and functional properties among species, among the auditory and vestibular organs, and among hair cell positions within the organ. Here, we briefly review synaptic morphology and connectivity and then focus on stimulus-secretion coupling at hair cell synapses.

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Section: Ion Channels Affecting Hair Cell Presynaptic Functionmentioning

confidence: 96%

Hair cell ribbon synapses

2006

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“…Alternatively, age-related changes in the ionic membrane properties of the ampullary epithelium could affect the frequency selectivity of electroreceptors. Frequency selectivity of hair cell receptors is related to the electrical resonance of receptor potentials in vertebrates [Crawford and Fettiplace, 1981;Art et al, 1986;Hudspeth, 1989] including the electroreceptors of elasmobranch and teleost fishes [Clusin and Bennett, 1979;Viancour, 1979;Zakon and Meyer, 1983]. The oscillation of receptor potentials and the resultant electrical resonance along the receptor epithelium is due to the interaction between inward calcium and outward calcium-dependent potassium currents [Lewis and Hudspeth, 1983;Fettiplace, 1987].…”

Section: Discussionmentioning

confidence: 99%

Ontogenetic Changes in the Response Properties of the Peripheral Electrosensory System in the Atlantic Stingray <i>(Dasyatis sabina)</i>

Sisneros

Tricas

2002

Brain Behav Evol

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Adult stingrays use their ampullary electroreceptors to detect prey and locate mates, but the response properties and function of their electrosensory system in the pre-adult stages are unknown. We examined the response properties of Atlantic stingray (Dasyatis sabina) electrosensory primary afferent neurons through ontogeny to determine whether encoding of electrosensory information changes with age, and how it relates to the ontogenetic encoding of biologically relevant electric stimuli. We show that during development electrosensory primary afferents increase resting discharge regularity, show an upward shift in best frequency (BF), an increase in neural sensitivity, and a decrease in bandpass. These ontogenetic changes in the response properties of the stingray electrosense are consistent with sensory adaptations to enhance the avoidance of large predators as young, and increase the location of prey and mates as adults.

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“…19 By contrast, our modeling framework highlights the fact that the velocity impulse response reflects not only the local mechanics at the point of measurement but depends, in fact, on the mechanics of the entire cochlea. The model thus underscores the fundamental difference between the biophysical basis of tuning in the mammalian cochlea-where tuning arises globally and involves the collective action of the outer hair cells in providing coherent amplification of traveling waves ͑e.g., Neely, 1983;Zweig, 1991;de Boer, 1995a;Olson, 1999͒-and its origin in lower vertebrates, where tuning mechanisms local to the sensory hair cellsuch as electrical and mechanical resonances ͑e.g., Crawford and Fettiplace, 1981;Lewis, 1985;Art et al, 1986;Hudspeth and Lewis, 1988;Weiss and Leong, 1985;Freeman and Weiss, 1990͒ together with tuned amplification of hairbundle motion ͑e.g., Crawford and Fettiplace, 1985;Martin and Hudspeth, 1999͒-are believed paramount.…”

Section: A Simple Modelmentioning

confidence: 99%

Frequency glides in click responses of the basilar membrane and auditory nerve: Their scaling behavior and origin in traveling-wave dispersion

Shera

2001

The Journal of the Acoustical Society of America

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Frequency modulations (or glides), reported in impulse responses of both the auditory nerve and the basilar membrane, represent a change over time in the instantaneous frequency of oscillation of the response waveform. Although the near invariance of glides with stimulus intensity indicates that they are not the consequence of nonlinear or active processes in the inner ear, their origin has remained otherwise obscure. This paper combines theory with experimental data to explore the basic phenomenology of glides. When expressed in natural dimensionless form, glides are shown to have a universal form nearly independent of cochlear location for characteristic frequencies (CFs) above approximately 1.5 kHz (the "scaling region"). In the apex of the cochlea, by contrast, glides appear to depend strongly on CF. In the scaling region, instantaneous-frequency trajectories are shown to be approximately equal to the "inverse group delays" of basilar-membrane transfer functions measured at the same locations. The inverse group delay, obtained by functionally inverting the transfer-function group-delay-versus-frequency curve, specifies the frequency component of a broadband stimulus expected to be driving the cochlear partition at the measurement point as a function of time. The approximate empirical equality of the two functions indicates that glides are closely related to cochlear traveling-wave dispersion and suggests that they originate primarily through the time dependence of the effective driving pressure force at the measurement location. Calculations in a one-dimensional cochlear model based on solution to the inverse problem in squirrel monkey [Zweig, J. Acoust. Soc. Am. 89, 1229-1254 (1991)] support this conclusion. In contrast to previous models for glides, which locate their origin in the differential build-up and decay of multiple micromechanical resonances local to each radial cross section of the organ of Corti, the model presented here identifies glides as the global consequence of the dispersive character of wave propagation in the cochlea.

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Electrical resonance and membrane currents in turtle cochlear hair cells

Cited by 70 publications

References 15 publications

Hair cell ribbon synapses

Hair cell ribbon synapses

Ontogenetic Changes in the Response Properties of the Peripheral Electrosensory System in the Atlantic Stingray <i>(Dasyatis sabina)</i>

Frequency glides in click responses of the basilar membrane and auditory nerve: Their scaling behavior and origin in traveling-wave dispersion

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