Electrical Remodelling in Cardiac Disease

Ravens, Ursula; Peyronnet, Rémi

doi:10.3390/cells12020230

Cited by 4 publications

(3 citation statements)

References 43 publications

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“…Changes in the functional activity of ion channels play an important role in HF ( 21 ). Nevertheless, the mechanisms responsible for these alterations remain not fully understood.…”

Section: Clinical Presentationmentioning

confidence: 99%

Ion channel trafficking implications in heart failure

Reisqs,

Qu,

Boutjdir

2024

Front. Cardiovasc. Med.

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Heart failure (HF) is recognized as an epidemic in the contemporary world, impacting around 1%–2% of the adult population and affecting around 6 million Americans. HF remains a major cause of mortality, morbidity, and poor quality of life. Several therapies are used to treat HF and improve the survival of patients; however, despite these substantial improvements in treating HF, the incidence of HF is increasing rapidly, posing a significant burden to human health. The total cost of care for HF is USD 69.8 billion in 2023, warranting a better understanding of the mechanisms involved in HF. Among the most serious manifestations associated with HF is arrhythmia due to the electrophysiological changes within the cardiomyocyte. Among these electrophysiological changes, disruptions in sodium and potassium currents’ function and trafficking, as well as calcium handling, all of which impact arrhythmia in HF. The mechanisms responsible for the trafficking, anchoring, organization, and recycling of ion channels at the plasma membrane seem to be significant contributors to ion channels dysfunction in HF. Variants, microtubule alterations, or disturbances of anchoring proteins lead to ion channel trafficking defects and the alteration of the cardiomyocyte's electrophysiology. Understanding the mechanisms of ion channels trafficking could provide new therapeutic approaches for the treatment of HF. This review provides an overview of the recent advances in ion channel trafficking in HF.

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“…Changes in the functional activity of ion channels play an important role in HF ( 21 ). Nevertheless, the mechanisms responsible for these alterations remain not fully understood.…”

Section: Clinical Presentationmentioning

confidence: 99%

Ion channel trafficking implications in heart failure

Reisqs,

Qu,

Boutjdir

2024

Front. Cardiovasc. Med.

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“…Finally, cell uncoupling, along with cardiac myocyte disarmament and extensive fibrosis, lead to gap junctions and non-uniformity of anisotropy modulating AF. In addition, pre-exceeding CV diseases, such as myocardial infarction, cardiomyopathies, myocarditis, and cardiac hypertrophy, through the strength of local mechanical forces, loss of cardiac myocytes and extensive fibrosis intervene in anisotropy modality of cardiac electrical conductivity and shaping arrhythmogenic substrate [59].…”

Section: Adverse Cardiac Remodelingmentioning

confidence: 99%

“…Possibly, it depends on the distinguished presence of matrix metalloproteinases, their inhibitors, and pro-inflammatory molecules involved in the subsequent regulation of collagen synthesis and degradation. The accumulation of collagen, other matrix proteins (elastin, fibronectin 1, fibrillin 1), and proteoglycans in abundance lead to severe heterogeneous areas in the atria with variable alteration of electrophysiological properties [59]. This eventually leads to changes in myocardial cell architecture, such as elongation and disturbed alignment of demarcated fibers.…”

Section: Adverse Cardiac Remodelingmentioning

confidence: 99%

Biomarkers of Atrial Fibrillation Recurrence in Patients with Paroxysmal or Persistent Atrial Fibrillation Following External Direct Current Electrical Cardioversion

et al. 2023

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Atrial fibrillation (AF) is associated with atrial remodeling, cardiac dysfunction, and poor clinical outcomes. External direct current electrical cardioversion is a well-developed urgent treatment strategy for patients presenting with recent-onset AF. However, there is a lack of accurate predictive serum biomarkers to identify the risks of AF relapse after electrical cardioversion. We reviewed the currently available data and interpreted the findings of several studies revealing biomarkers for crucial elements in the pathogenesis of AF and affecting cardiac remodeling, fibrosis, inflammation, endothelial dysfunction, oxidative stress, adipose tissue dysfunction, myopathy, and mitochondrial dysfunction. Although there is ample strong evidence that elevated levels of numerous biomarkers (such as natriuretic peptides, C-reactive protein, galectin-3, soluble suppressor tumorigenicity-2, fibroblast growth factor-23, turn-over collagen biomarkers, growth differential factor-15) are associated with AF occurrence, the data obtained in clinical studies seem to be controversial in terms of their predictive ability for post-cardioversion outcomes. Novel circulating biomarkers are needed to elucidate the modality of this approach compared with conventional predictive tools. Conclusions: Biomarker-based strategies for predicting events after AF treatment require extensive investigation in the future, especially in the presence of different gender and variable comorbidity profiles. Perhaps, a multiple biomarker approach exerts more utilization for patients with different forms of AF than single biomarker use.

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