Electrical Nanobiosensors for Nucleic Acid Based Diagnostics

Ji, Daizong; Zhao, Jun; Liu, Yunqi; Wei, Dacheng

doi:10.1021/acs.jpclett.3c00495

Cited by 5 publications

(2 citation statements)

References 101 publications

(214 reference statements)

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“…When GFET is used as a biosensor, analytes could change one or several parameters of the graphene channel under the electric field, which in turn generates variations in the current or potential signal. , Specifically, biorecognition elements are immobilized on the channel via different linkers. These elements will concentrate the targets at the solution/graphene interface (Figure d).…”

Section: Structure and Working Principle Of Gfet Biosensormentioning

confidence: 99%

Sensitivity-Enhancing Strategies of Graphene Field-Effect Transistor Biosensors for Biomarker Detection

Zhao,

Zhang,

Chen

et al. 2024

ACS Sens.

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The ultrasensitive recognition of biomarkers plays a crucial role in the precise diagnosis of diseases. Graphene-based field-effect transistors (GFET) are considered the most promising devices among the next generation of biosensors. GFET biosensors possess distinct advantages, including label-free, ease of integration and operation, and the ability to directly detect biomarkers in liquid environments. This review summarized recent advances in GFET biosensors for biomarker detection, with a focus on interface functionalization. Various sensitivity-enhancing strategies have been overviewed for GFET biosensors, from the perspective of optimizing graphene synthesis and transfer methods, refinement of surface functionalization strategies for the channel layer and gate electrode, design of biorecognition elements and reduction of nonspecific adsorption. Further, this review extensively explores GFET biosensors functionalized with antibodies, aptamers, and enzymes. It delves into sensitivity-enhancing strategies employed in the detection of biomarkers for various diseases (such as cancer, cardiovascular diseases, neurodegenerative disorders, infectious viruses, etc.) along with their application in integrated microfluidic systems. Finally, the issues and challenges in strategies for the modulation of biosensing interfaces are faced by GFET biosensors in detecting biomarkers.

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Section: Structure and Working Principle Of Gfet Biosensormentioning

confidence: 99%

Sensitivity-Enhancing Strategies of Graphene Field-Effect Transistor Biosensors for Biomarker Detection

Zhao,

Zhang,

Chen

et al. 2024

ACS Sens.

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“…Nucleic acid detection is the most sensitive detection method for early viral infection and plays a key role in diagnosing and treating disease [53]. The RT-PCR method is the gold standard for detecting SARS-CoV-2, but the diagnostic process is complicated and time consuming.…”

Section: Gfet Biosensors Based On Nucleic Acid Hybridization Detectio...mentioning

confidence: 99%

The Application of Graphene Field-Effect Transistor Biosensors in COVID-19 Detection Technology: A Review

Liang,

Cao,

Xiao

et al. 2023

Sensors

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Coronavirus disease 2019 (COVID-19) is a disease caused by the infectious agent of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2). The primary method of diagnosing SARS-CoV-2 is nucleic acid detection, but this method requires specialized equipment and is time consuming. Therefore, a sensitive, simple, rapid, and low-cost diagnostic test is needed. Graphene field-effect transistor (GFET) biosensors have become the most promising diagnostic technology for detecting SARS-CoV-2 due to their advantages of high sensitivity, fast-detection speed, label-free operation, and low detection limit. This review mainly focus on three types of GFET biosensors to detect SARS-CoV-2. GFET biosensors can quickly identify SARS-CoV-2 within ultra-low detection limits. Finally, we will outline the pros and cons of the diagnostic approaches as well as future directions.

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Interface‐Engineered Field‐Effect Transistor Electronic Devices for Biosensing

Zhang,

Chen,

et al. 2023

Advanced Materials

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Promising advances in molecular medicine have promoted the urgent requirement for reliable and sensitive diagnostic tools. Electronic biosensing devices based on field‐effect transistors (FETs) exhibit a wide range of benefits, including rapid and label‐free detection, high sensitivity, easy operation, and capability of integration, possessing significant potential for application in disease screening and health monitoring. In this perspective, the tremendous efforts and achievements in the development of high‐performance FET biosensors in the past decade are summarized, with emphasis on the interface engineering of FET‐based electrical platforms for biomolecule identification. First, an overview of engineering strategies for interface modulation and recognition element design is discussed in detail. For a further step, the applications of FET‐based electrical devices for in vitro detection and real‐time monitoring in biological systems are comprehensively reviewed. Finally, the key opportunities and challenges of FET‐based electronic devices in biosensing are discussed. It is anticipated that a comprehensive understanding of interface engineering strategies in FET biosensors will inspire additional techniques for developing highly sensitive, specific, and stable FET biosensors as well as emerging designs for next‐generation biosensing electronics.

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Electrical Nanobiosensors for Nucleic Acid Based Diagnostics

Cited by 5 publications

References 101 publications

Sensitivity-Enhancing Strategies of Graphene Field-Effect Transistor Biosensors for Biomarker Detection

Sensitivity-Enhancing Strategies of Graphene Field-Effect Transistor Biosensors for Biomarker Detection

The Application of Graphene Field-Effect Transistor Biosensors in COVID-19 Detection Technology: A Review

Interface‐Engineered Field‐Effect Transistor Electronic Devices for Biosensing

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