Electrical inhibition of preterm birth: Inhibition of uterine contractility in the rabbit and pup births in the rat

Karsdon, Jeffrey; Garfield, Robert E.; Shi, Shao Qing; Maner, William L.; Saade, George R.

doi:10.1016/j.ajog.2005.05.009

Cited by 17 publications

(17 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The authors concluded that though the mechanism by which electrical inhibition acted was not well understood, it was seen to have a role in inhibiting preterm and even at‐term uterine contractions. Additionally, through their simultaneous hormonal studies, they reported that such inhibitory actions did not correlate with systematic changes in pregnancy hormones, or others .…”

Section: Resultsmentioning

confidence: 99%

Safety of Sacral Nerve Stimulation in Pregnancy: A Literature Review

Yaiesh

Al‐Terki

Al-Shaiji

2016

Neuromodulation: Technology at the Neural Interface

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 99%

Safety of Sacral Nerve Stimulation in Pregnancy: A Literature Review

Yaiesh

Al‐Terki

Al-Shaiji

2016

Neuromodulation: Technology at the Neural Interface

View full text Add to dashboard Cite

“…It is known that uterine smooth muscles regulate tension of the uterine wall and peristaltic movements of the uterus under control of the autonomic nervous system. Electrical stimulation delivered to the uterus is shown to be able to inhibit uterine contractions and delays term‐labour 1 . A study performed in our lab also reported that uterine electrical stimulation decreased frequencies and amplitudes of uterine contractions and delayed delivery labour in a rodent model of term and premature labour 2…”

Section: Introductionmentioning

confidence: 74%

Effects and mechanisms of vaginal electrical stimulation on gastric tone in dogs

Guan

Hou

Zhu³

et al. 2007

Neurogastroenterology Motil

View full text Add to dashboard Cite

Electrical stimulation of one part of the gut may have beneficial or adverse effects on another region. We hypothesized that electrical stimulation of a visceral organ in one system might have an effect on another visceral organ system. That is, disorders of one system may be treated by interventions of another system and this may lead to a more convenient or less invasive therapies in some cases. The aim of this study was to evaluate the effects and mechanisms of vaginal electrical stimulation (VES) with different parameters on gastric tone and gastric slow waves in conscious dogs. Seven dogs were studied in two experiments. Experiment 1 was to study effects of VES on gastric tone and slow waves. Experiment 2 was performed in two sessions (long pulse VES plus guanethidine and VES with trains of long pulse plus guanethidine) to study involvements of possible sympathetic mechanisms. The results of our experiments were: (i) VES increased the gastric volume in a dose-dependent manner with the increase of stimulation frequency, amplitude or pulse width; (ii) VES had no effects on gastric slow waves; (iii) the inhibitory effect of VES with long pulses or trains of long pulses on gastric tone was abolished by guanethidine; and (iv) few or mild symptoms were noted with stimulation. VES decreases proximal gastric tone in an energy-dependent manner without affecting gastric slow waves. The inhibitory effect of VES is mediated by a sympathetic pathway. Hypertensive gastric tone might be treated using electrical stimulation of the vagina which is minimally invasive.

show abstract

“…We have shown some changes in uterine wave like activity. Changes in uterine contractility by direct electrical stimulation of the myometrium have already been demonstrated in rabbits and rats [6]. This caused inhibition of the uterine contractility.…”

Section: Discussionmentioning

confidence: 99%

“…The innervation of the uterus is entirely autonomic, arising from the inferior hypogastric plexus (sympathetic) and the pelvic splanchnic nerves (parasympathetic) from S2 to S5 [5]. In contrast to the fear of uterine contractions during SNS, there is evidence in rats and rabbits that direct electrical stimulation on the uterus can cause a decrease in contractility of the uterus during parturition [6].…”

Section: Introductionmentioning

confidence: 99%

The Effect of sacral nerve stimulation on uterine activity: a pilot study

Govaert¹,

Melenhorst²,

Link

et al. 2010

Colorectal Disease

View full text Add to dashboard Cite

We have shown some effect of SNS on uterine activity. In premenopausal women we discovered that SNS seems to exhibit no effect or an inhibitory effect rather than an excitatory effect on uterine activity. Based on the preliminary results of this study, we can not recommend any guidelines for SNS usage during conception and pregnancy. A larger study in premenopausal women with SNS is needed to investigate the significance of these changes.

show abstract

Electrical inhibition of preterm birth: Inhibition of uterine contractility in the rabbit and pup births in the rat

Cited by 17 publications

References 13 publications

Safety of Sacral Nerve Stimulation in Pregnancy: A Literature Review

Safety of Sacral Nerve Stimulation in Pregnancy: A Literature Review

Effects and mechanisms of vaginal electrical stimulation on gastric tone in dogs

The Effect of sacral nerve stimulation on uterine activity: a pilot study

Contact Info

Product

Resources

About