Electrical conduction in collagen. II. Some aspects of hydration

Bardelmeyer, G. H.

doi:10.1002/bip.1973.360121009

Cited by 14 publications

(7 citation statements)

References 12 publications

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“…The role of water content on the ionic conductance across protein biopolymers was reported by Bardelmeyer et al in 1973 in their work with collagen (in a form of a tendon) . It was demonstrated that the room temperature conductivity across collagen could be increased from ≈10 −11 S cm −1 at a water content of 8.5% to ≈10 −3 S cm −1 at saturation.…”

Section: Biomolecular Electronic Materials At the Macroscalementioning

confidence: 73%

“…This change in slope was attributed to proton conduction at lower water contents, and larger ion conduction at higher water contents. In further discussion on the matter by the same authors, they addressed the issue of the different contributions to the conductance of bound and loose water molecules within the structure—a concept that is highly relevant to more modern studies (not just in proteins), and often ignored. Protein‐bound water molecules have fundamentally different properties to loosely bound “matrix” water molecules.…”

Section: Biomolecular Electronic Materials At the Macroscalementioning

confidence: 99%

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Macroscale Biomolecular Electronics and Ionics

2018

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www.advmat.de www.advancedsciencenews.com modern semiconductor-based electronic processing. The melanin story is also an archetype of the more recent "DNA-debate" and questions as to whether proteins, lipids, polysaccharides, etc., can intrinsically sustain electronic conduction and hence ET in the solid state. [13,31,32,41] That said, it is now appropriate and timely to introduce the basic concepts of ionic conduction.

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Section: Biomolecular Electronic Materials At the Macroscalementioning

confidence: 73%

Section: Biomolecular Electronic Materials At the Macroscalementioning

confidence: 99%

Macroscale Biomolecular Electronics and Ionics

2018

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“…An additional important component in the PT is water molecules. The importance of water molecules has already been shown in one of the earliest studies of proton conduction across collagen in a form of a tendon, , as well as in recent studies . In terms of the PT mechanism, water molecules can bridge via hydrogen bonds between the different amino acids’ side chains on the surface of the protein-based scaffold, thus contributing to the PT pathway.…”

Section: Introductionmentioning

confidence: 94%

Proton Transport Across Collagen Fibrils and Scaffolds: The Role of Hydroxyproline

Orieshyna,

Puetzer,

Amdursky

2023

Biomacromolecules

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Collagen is one of the most studied proteins due to its fundamental role in creating fibrillar structures and supporting tissues in our bodies. Accordingly, collagen is also one of the most used proteins for making tissue-engineered scaffolds for various types of tissues. To date, the high abundance of hydroxyproline (Hyp) within collagen is commonly ascribed to the structure and stability of collagen. Here, we hypothesize a new role for the presence of Hyp within collagen, which is to support proton transport (PT) across collagen fibrils. For this purpose, we explore here three different collagen-based hydrogels: the first is prepared by the self-assembly of natural collagen fibrils, and the second and third are based on covalently linking between collagen via either a self-coupling method or with an additional cross-linker. Following the formation of the hydrogel, we introduce here a two-step reaction, involving (1) attaching methanesulfonyl to the −OH group of Hyp, followed by (2) removing the methanesulfonyl, thus reverting Hyp to proline (Pro). We explore the PT efficiency at each step of the reaction using electrical measurements and show that adding the methanesulfonyl group vastly enhances PT, while reverting Hyp to Pro significantly reduces PT efficiency (compared with the initial point) with different efficiencies for the various collagenbased hydrogels. The role of Hyp in supporting the PT can assist in our understanding of the physiological roles of collagen. Furthermore, the capacity to modulate conductivity across collagen is very important to the use of collagen in regenerative medicine.

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“…[ 62 ] The activation energy shows a linear relationship with water content but with different slopes under and above 50% water content. [ 135 ] Despite this early progress, there has been relatively little work on proton conducting proteins until recently.…”

Section: Natural Biopolymers As Proton Conductorsmentioning

confidence: 99%

Natural biopolymers as proton conductors in bioelectronics

et al. 2021

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Bioelectronic devices sense or deliver information at the interface between living systems and electronics by converting biological signals into electronic signals and vice-versa. Biological signals are typically carried by ions and small molecules. As such, ion conducting materials are ideal candidates in bioelectronics for an optimal interface. Among these materials, ion conducting polymers that are able to uptake water are particularly interesting because, in addition to ionic conductivity, their mechanical properties can closely match the ones of living tissue. In this review, we focus on a specific subset of ion-conducting polymers: proton (H + ) conductors that are naturally derived. We first provide a brief introduction of the proton conduction mechanism, and then outline the chemical structure and properties of representative proton-conducting natural biopolymers: polysaccharides (chitosan and glycosaminoglycans), peptides and proteins, and melanin. We then highlight examples of using these biopolymers in bioelectronic devices. We conclude with current challenges and future prospects for broader use of natural biopolymers as proton conductors in bioelectronics and potential translational applications.

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Electrical conduction in collagen. II. Some aspects of hydration

Cited by 14 publications

References 12 publications

Macroscale Biomolecular Electronics and Ionics

Macroscale Biomolecular Electronics and Ionics

Proton Transport Across Collagen Fibrils and Scaffolds: The Role of Hydroxyproline

Natural biopolymers as proton conductors in bioelectronics

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