Electrical Characterization of Micron-Sized Chambers Used as a Depot for Drug Delivery

Khan, Ahsan Noor; Ermakov, А. V.; Saunders, Theo; Giddens, Henry; Gould, David; Sukhorukov, Gleb B.; Hao, Yang

doi:10.1109/jsen.2022.3194717

Cited by 3 publications

(2 citation statements)

References 45 publications

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“…In this way, the drug delivery paradigm has been applied to encapsulate all sorts of drugs, from cytostatics to photodynamic agents [ 17 , 18 , 19 , 20 , 21 ]. Understanding drug bioavailability issues and fundamental disease mechanisms is driving researchers to develop increasingly complex DDSs designed to provide enhanced drug stability, prolonged circulation time, tolerability, retention in lesion area, increased internalization by a specific cell types, controlled release profile, responsiveness to a specific endogenous and exogenous triggers (IR radiation, magnetic field, electric field, ultrasound, temperature, pH, and enzymes), and others [ 22 , 23 , 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

Current Principles, Challenges, and New Metrics in pH-Responsive Drug Delivery Systems for Systemic Cancer Therapy

et al. 2023

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The paradigm of drug delivery via particulate formulations is one of the leading ideas that enable overcoming limitations of traditional chemotherapeutic agents. The trend toward more complex multifunctional drug carriers is well-traced in the literature. Nowadays, the prospectiveness of stimuli-responsive systems capable of controlled cargo release in the lesion nidus is widely accepted. Both endogenous and exogenous stimuli are employed for this purpose; however, endogenous pH is the most common trigger. Unfortunately, scientists encounter multiple challenges on the way to the implementation of this idea related to the vehicles’ accumulation in off-target tissues, their immunogenicity, the complexity of drug delivery to intracellular targets, and finally, the difficulties in the fabrication of carriers matching all imposed requirements. Here, we discuss fundamental strategies for pH-responsive drug delivery, as well as limitations related to such carriers’ application, and reveal the main problems, weaknesses, and reasons for poor clinical results. Moreover, we attempted to formulate the profiles of an “ideal” drug carrier in the frame of different strategies drawing on the example of metal-comprising materials and considered recently published studies through the lens of these profiles. We believe that this approach will facilitate the formulation of the main challenges facing researchers and the identification of the most promising trends in technology development.

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Section: Introductionmentioning

confidence: 99%

Current Principles, Challenges, and New Metrics in pH-Responsive Drug Delivery Systems for Systemic Cancer Therapy

et al. 2023

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“…The electrical biosensor [ 1 ] for electrical triggers in drug delivery systems (DDS) [ 2 ] has become popular because of the advancement of nanotechnology [ 3 , 4 ], making the nanochip smaller than the minimum red blood cell size of 1.7 µm [ 5 ]. This nanochip [ 6 , 7 , 8 ] is used as a drug reservoir, carrier, and release to control the drug load and delivery [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

CuZn Complex Used in Electrical Biosensors for Drug Delivery Systems

Miskon

Zaidi

2022

Materials

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This paper is to discuss the potential of using CuZn in an electrical biosensor drug carrier for drug delivery systems. CuZn is the main semiconductor ingredient that has great promise as an electrochemical detector to trigger releases of active pharmaceutical ingredients (API). This CuZn biosensor is produced with a green metal of frameworks, which is an anion node in conductive polymers linked by bioactive ligands using metal–polymerisation technology. The studies of Cu, Zn, and their oxides are highlighted by their electrochemical performance as electrical biosensors to electrically trigger API. The three main problems, which are glucose oxidisation, binding affinity, and toxicity, are highlighted, and their solutions are given. Moreover, their biocompatibilities, therapeutic efficacies, and drug delivery efficiencies are discussed with details given. Our three previous investigations of CuZn found results similar to those of other authors’ in terms of multiphases, polymerisation, and structure. This affirms that our research is on the right track, especially that related to green synthesis using plant extract, CuZn as a nanochip electric biosensor, and bioactive ligands to bind API, which are limited to the innermost circle of the non-enzymatic glucose sensor category.

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A New Method for Calculating the Electric Field Distribution in Particle-Particle Rotating Systems

Kang,

ZHANG

2024

Preprint

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Electrical Characterization of Micron-Sized Chambers Used as a Depot for Drug Delivery

Cited by 3 publications

References 45 publications

Current Principles, Challenges, and New Metrics in pH-Responsive Drug Delivery Systems for Systemic Cancer Therapy

Current Principles, Challenges, and New Metrics in pH-Responsive Drug Delivery Systems for Systemic Cancer Therapy

CuZn Complex Used in Electrical Biosensors for Drug Delivery Systems

A New Method for Calculating the Electric Field Distribution in Particle-Particle Rotating Systems

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